抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Surface plasmons are waves that propagate along the surface of a conductor. By altering the structure of a metal's surface, the properties of surface plasmons--in particular their interaction with light--can be tailored, which offers the potential for developing new types of photonic device. This could lead to miniaturized photonic circuits with length scales that are much smaller than those currently achieved. Surface plasmons are being explored for their potential in subwavelength optics, data storage, light generation, microscopy and bio-photonics.

/pdf/surface-plasmon-subwavelength-optics-5e55p12p4o.pdf

Surface plasmon subwavelength optics

We show that microstructures built from nonmagnetic conducting sheets exhibit an effective magnetic permeability /spl mu//sub eff/, which can be tuned to values not accessible in naturally occurring materials, including large imaginary components of /spl mu//sub eff/. The microstructure is on a scale much less than the wavelength of radiation, is not resolved by incident microwaves, and uses a very low density of metal so that structures can be extremely lightweight. Most of the structures are resonant due to internal capacitance and inductance, and resonant enhancement combined with compression of electrical energy into a very small volume greatly enhances the energy density at critical locations in the structure, easily by factors of a million and possibly by much more. Weakly nonlinear materials placed at these critical locations will show greatly enhanced effects raising the possibility of manufacturing active structures whose properties can be switched at will between many states.

/pdf/magnetism-from-conductors-and-enhanced-nonlinear-phenomena-2fpnoamwae.pdf

Magnetism from conductors and enhanced nonlinear phenomena

Fundamentals of Plasmonics.- Electromagnetics of Metals.- Surface Plasmon Polaritons at Metal / Insulator Interfaces.- Excitation of Surface Plasmon Polaritons at Planar Interfaces.- Imaging Surface Plasmon Polariton Propagation.- Localized Surface Plasmons.- Electromagnetic Surface Modes at Low Frequencies.- Applications.- Plasmon Waveguides.- Transmission of Radiation Through Apertures and Films.- Enhancement of Emissive Processes and Nonlinearities.- Spectroscopy and Sensing.- Metamaterials and Imaging with Surface Plasmon Polaritons.- Concluding Remarks.

/pdf/plasmonics-fundamentals-and-applications-4syb9877sr.pdf

Plasmonics: Fundamentals and Applications

Electronic circuits provide us with the ability to control the transport and storage of electrons. However, the performance of electronic circuits is now becoming rather limited when digital information needs to be sent from one point to another. Photonics offers an effective solution to this problem by implementing optical communication systems based on optical fibers and photonic circuits. Unfortunately, the micrometer-scale bulky components of photonics have limited the integration of these components into electronic chips, which are now measured in nanometers. Surface plasmon-based circuits, which merge electronics and photonics at the nanoscale, may offer a solution to this size-compatibility problem. Here we review the current status and future prospects of plasmonics in various applications including plasmonic chips, light generation, and nanolithography.

/pdf/plasmonics-merging-photonics-and-electronics-at-nanoscale-3vxc7s7v4s.pdf

Plasmonics: merging photonics and electronics at nanoscale dimensions.

Metals such as silver support surface plasmons: electromagnetic surface excitations localized near the surface that originate from the free electrons of the metal. Surface modes are also observed on highly conducting surfaces perforated by holes. We establish a close connection between the two, showing that electromagnetic waves in both materials are governed by an effective permittivity of the same plasma form. The size and spacing of holes can readily be controlled on all relevant length scales, which allows the creation of designer surface plasmons with almost arbitrary dispersion in frequency and in space, opening new vistas in surface plasmon optics.

https://science.sciencemag.org/content/sci/305/5685/847.full.pdf

Mimicking Surface Plasmons with Structured Surfaces

Light usually diffracts in all directions when it emerges from a subwavelength aperture, which puts a lower limit on the size of features that can be used in photonics. This limitation can be overcome by creating a periodic texture on the exit side of a single aperture in a metal film. The transmitted light emerges from the aperture as a beam with a small angular divergence (approximately ±3°) whose directionality can be controlled. This finding is especially surprising, considering that the radiating region is mainly confined to an area with lateral dimensions comparable to the wavelength of the light. The device occupies no more than one cubic micrometer and, when combined with enhanced transmission, suggests that a wide range of photonic applications is possible.

https://science.sciencemag.org/content/sci/early/2002/06/20/science.1071895.full.pdf

Beaming light from a subwavelength aperture.

We present a fully three-dimensional theoretical study of the extraordinary transmission of light through subwavelength hole arrays in optically thick metal films. Good agreement is obtained with experimental data. An analytical minimal model is also developed, which conclusively shows that the enhancement of transmission is due to tunneling through surface plasmons formed on each metal-dielectric interface. Different regimes of tunneling (resonant through a ``surface plasmon molecule,'' or sequential through two isolated surface plasmons) are found depending on the geometrical parameters defining the system.

https://arxiv.org/pdf/cond-mat/0008204.pdf

Theory of extraordinary optical transmission through subwavelength hole arrays.

Transmission metallic gratings with very narrow and deep enough slits can exhibit transmission resonances for wavelengths larger than the period of the grating. By using a transfer matrix formalism and a quasianalytical model based on a modal expansion, we show that there are two possible ways of transferring light from the upper surface to the lower one: by the excitation of coupled surface plasmon polaritons on both surfaces of the metallic grating or by the coupling of incident plane waves with waveguide resonances located in the slits. Both mechanisms can lead to almost perfect transmittance for those particular resonances.

Francisco J. Garcia-Vidal

Papers

Mimicking Surface Plasmons with Structured Surfaces

Beaming light from a subwavelength aperture.

Theory of extraordinary optical transmission through subwavelength hole arrays.

Transmission Resonances on Metallic Gratings with Very Narrow Slits

Fornel, Frédérique de