Author
François Cauchy
Other affiliations: Pierre-and-Marie-Curie University, Beaujon Hospital, Paris Diderot University ...read more
Bio: François Cauchy is an academic researcher from University of Paris. The author has contributed to research in topics: Medicine & Hepatectomy. The author has an hindex of 23, co-authored 130 publications receiving 2096 citations. Previous affiliations of François Cauchy include Pierre-and-Marie-Curie University & Beaujon Hospital.
Papers
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TL;DR: PIVKA-II was more efficient than AFP for the diagnosis of early HCC, and could be used as a predictive biomarker of MVI.
215 citations
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TL;DR: Changing trends in recipient and donor age are summarised and age matching between the donor and the recipient should be incorporated into allocation policies with a multistep approach.
171 citations
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TL;DR: The profile of patients undergoing liver resection has changed and now includes more high-risk patients with diseased parenchyma undergoing major hepatectomy for malignancy, which is responsible for the stability in mortality rates over the years.
Abstract: Objectives
Recent improvements in surgical technique have extended the indications for liver resection. The aims of this study were to assess whether this extension is associated with a changing patient profile and to evaluate how this potential shift has influenced mortality after liver resection in order to define standard expectations for hepatectomy.
153 citations
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TL;DR: This study showed that several evidence-based facts could be combined to define a new conceptual technique of laparoscopic right hepatectomy allowing for low blood loss and morbidity.
Abstract: Objective To evaluate a new conceptual technique of laparoscopic right hepatectomy. Background Despite significant improvements in surgical care in the last decades, morbidity is still high after major hepatectomy. Blood loss and transfusions are known to significantly increase the risk of postoperative complications and cancer recurrence after liver resection. A laparoscopic approach may improve perioperative outcomes in these cases, but data in literature are limited and the surgical technique is not yet standardized. Methods A new conceptual technique of right hepatectomy was designed using evidence-based facts and oncologic rules: laparoscopy with pneumoperitoneum, low central venous pressure, intermittent pedicle clamping, anterior approach without mobilization, and parenchymal section with ultrasonic dissector. Thirty patients were prospectively enrolled between October 2011 and September 2013. Primary endpoint was intraoperative blood loss. Results Eighty percent of patients underwent surgery for malignant disease and cirrhosis was present in 11 patients. Benign lesions accounted for 13% of indications, whereas living liver donation was performed in 2 cases. Median blood loss was 100 mL (50-700) and transfusion rate was 7%. Five patients (16.6%) required conversion to laparotomy, including 2 using hybrid technique. The median operative time was 360 minutes (210-510). R0 resection rate was 87% (21/24). Postoperative morbidity rate was 23% (7/30) with 8 complications including 6 Clavien III-IV. No respiratory complication occurred. The median hospital stay was 8 days. No patient died. Conclusions This study showed that several evidence-based facts could be combined to define a new conceptual technique of laparoscopic right hepatectomy allowing for low blood loss and morbidity.
143 citations
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TL;DR: Pure laparoscopy allows reducing PPCs in patients requiring major liver resection in patients undergoing OMH or LMH, and the overall incidence and types of postoperative pulmonary complications were significantly lower in the laparoscopic group than in the open group.
Abstract: Objective:To compare both incidence and types of postoperative pulmonary complications (PPCs) between laparoscopic major hepatectomy (LMH) and open major hepatectomy (OMH).Background:LMHs are increasingly performed. Yet, the benefits of laparoscopy over laparotomy regarding PPCs remain unknown.Metho
112 citations
Cited by
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TL;DR: The following Clinical Practice Guidelines will give up-to-date advice for the clinical management of patients with hepatocellular carcinoma, as well as providing an in-depth review of all the relevant data leading to the conclusions herein.
7,851 citations
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2,777 citations
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TL;DR: The findings suggest that, although not the presenting feature, mild cognitive decline may be evident in the early stages of CJD associated with human cadaveric growth hormone treatment, and progression to dementia is best predicted by performance on neuropsychological tests.
1,194 citations
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Iwate Medical University1, University of Pittsburgh2, Louisiana State University3, Toho University4, Mayo Clinic5, Royal Brisbane and Women's Hospital6, Tokyo Medical and Dental University7, Beaumont Hospital8, Ghent University9, University Hospital Southampton NHS Foundation Trust10, Sungkyunkwan University11, University of Oslo12, Yonsei University13, Vita-Salute San Raffaele University14, Zhejiang University15, University of Toronto16, Memorial Hospital of South Bend17, Fujita Health University18, Pamela Youde Nethersole Eastern Hospital19, University of São Paulo20, Hospital Italiano de Buenos Aires21, Huazhong University of Science and Technology22, South University23, Memorial Sloan Kettering Cancer Center24, University of Queensland25, Lilavati Hospital and Research Centre26, University of Hong Kong27, University of Zurich28, McGill University29, Washington University in St. Louis30
TL;DR: The Second International Consensus Conference on Laparoscopic Liver Resections (LLR) was held in Morioka, Japan, from October 4 to 6, 2014 to evaluate the current status of laparoscopic liver surgery and to provide recommendations to aid its future development.
Abstract: The use of laparoscopy for liver surgery is increasing rapidly. The Second International Consensus Conference on Laparoscopic Liver Resections (LLR) was held in Morioka, Japan, from October 4 to 6, 2014 to evaluate the current status of laparoscopic liver surgery and to provide recommendations to aid its future development. Seventeen questions were addressed. The first 7 questions focused on outcomes that reflect the benefits and risks of LLR. These questions were addressed using the Zurich-Danish consensus conference model in which the literature and expert opinion were weighed by a 9-member jury, who evaluated LLR outcomes using GRADE and a list of comparators. The jury also graded LLRs by the Balliol Classification of IDEAL. The jury concluded that MINOR LLRs had become standard practice (IDEAL 3) and that MAJOR liver resections were still innovative procedures in the exploration phase (IDEAL 2b). Continued cautious introduction of MAJOR LLRs was recommended. All of the evidence available for scrutiny was of LOW quality by GRADE, which prompted the recommendation for higher quality evaluative studies. The last 10 questions focused on technical questions and the recommendations were based on literature review and expert panel opinion. Recommendations were made regarding preoperative evaluation, bleeding controls, transection methods, anatomic approaches, and equipment. Both experts and jury recognized the need for a formal structure of education for those interested in performing major laparoscopic LLR because of the steep learning curve.
1,064 citations
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University of Southampton1, Vita-Salute San Raffaele University2, Oslo University Hospital3, Ghent University4, AZ Groeninge5, University of Cambridge6, Leeds Teaching Hospitals NHS Trust7, Pierre-and-Marie-Curie University8, Beaujon Hospital9, University of Birmingham10, Maastricht University Medical Centre11, Louisiana State University12, University of Zurich13, Royal Free Hospital14, University of Pittsburgh15, University of Mainz16, Mater Health Services17, Iwate Medical University18, Mayo Clinic19
TL;DR: The Southampton Guidelines have amalgamated the available evidence and a wealth of experts’ knowledge taking in consideration the relevant stakeholders’ opinions and complying with the international methodology standards.
Abstract: Objective:The European Guidelines Meeting on Laparoscopic Liver Surgery was held in Southampton on February 10 and 11, 2017 with the aim of presenting and validating clinical practice guidelines for laparoscopic liver surgery.Background:The exponential growth of laparoscopic liver surgery in recent
459 citations