François Coulier

TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.

TL;DR: By screening a mouse cosmid library with a human HST probe under reduced conditions of stringency, one of them was identified as a new member of the fibroblast growth factor gene family, and called FGF.6.

TL;DR: The respective expression of 8 of the 9 characterized FGF genes, and of the 4 known FGF receptor genes, in a panel of 10 tumor‐cell lines and 103 breast‐tumor samples, using RT‐PCR and Northern‐blot analyses are studied.

TL;DR: The comparison of FGF and FGF receptor sequences in vertebrates and nonvertebrates shows that the F GF and F GF receptor families have evolved through phases of gene duplications, one of which may have coincided with the emergence of vertebrates, in relation with their new system of body scaffold.

TL;DR: It was shown that cognates (orthologs) of human duplicated genes can be found in other vertebrates, including bony fishes, and that large-scale duplications occurred after the echinoderms/chordates split and before the bony vertebrate radiation.