F
François Karch
Researcher at University of Geneva
Publications - 73
Citations - 8704
François Karch is an academic researcher from University of Geneva. The author has contributed to research in topics: Bithorax complex & Chromatin. The author has an hindex of 45, co-authored 73 publications receiving 8098 citations. Previous affiliations of François Karch include Harvard University & Hungarian Academy of Sciences.
Papers
More filters
Journal ArticleDOI
An optimized transgenesis system for Drosophila using germ-line-specific φC31 integrases
TL;DR: The efficiency, ease-of-use, and versatility obtained here with the φC31-based integration system represents an important advance in transgenesis and opens up the possibility of systematic, high-throughput screening of large cDNA sets and regulatory elements.
Journal ArticleDOI
Molecular Genetics of the Bithorax Complex in Drosophila melanogaster
Welcome Bender,Michael Akam,François Karch,Philip A. Beachy,Mark Peifer,Pierre Spierer,Edward B. Lewis,David S. Hogness +7 more
TL;DR: The DNA of the bithorax complex has been isolated, and a region of 195,000 base pairs that covers the left half of the complex is described here.
Journal ArticleDOI
The Trithorax-like gene encodes the Drosophila GAGA factor
Gabriella Farkas,János Gausz,Mireille Galloni,Mireille Galloni,Gunter Reuter,Henrik Gyurkovics,François Karch +6 more
TL;DR: The genetic analysis suggests that the chromatin modelling function of the GAGA factor is not restricted to promoter regions, and the Trithorax-like gene described here is required for the normal expression of the homeotic genes and is a modifier of position-effect variegation.
Journal ArticleDOI
The abdominal region of the bithorax complex
François Karch,Barbara Weiffenbach,Mark Peifer,Welcome Bender,Ian Duncan,Susan E. Celniker,Madeline A. Crosby,Edward B. Lewis +7 more
TL;DR: A chromosomal walk in the bithorax complex of Drosophila has been extended 215 kb through the right half of the complex, and lesions for over 40 mutations have been located on the DNA map.
Journal ArticleDOI
GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7
Jan A. van der Knaap,B.R. Prashanth Kumar,Yuri M. Moshkin,Karin Langenberg,Jeroen Krijgsveld,Albert J. R. Heck,François Karch,C. Peter Verrijzer +7 more
TL;DR: It is shown that the essential Drosophila ubiquitin-specific protease 7 (USP7) contributes to epigenetic silencing of homeotic genes by Polycomb (Pc), and these results implicate a biosynthetic enzyme in chromatin control via ubiquit in regulation.