F
François Vaillant
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 80
Citations - 13288
François Vaillant is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Stem cell & Population. The author has an hindex of 42, co-authored 80 publications receiving 11996 citations. Previous affiliations of François Vaillant include Monash Medical Centre & University of Glasgow.
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Journal ArticleDOI
Generation of a functional mammary gland from a single stem cell
Mark Shackleton,Mark Shackleton,François Vaillant,François Vaillant,Kaylene J. Simpson,Kaylene J. Simpson,John Stingl,Gordon K. Smyth,Marie Liesse Asselin-Labat,Marie Liesse Asselin-Labat,Li Wu,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Jane E. Visvader,Jane E. Visvader +14 more
TL;DR: It is shown that a single cell, marked with a LacZ transgene, can reconstitute a complete mammary gland in vivo and establish that single cells within the Lin-CD29hiCD24+ population are multipotent and self-renewing, properties that define them as MaSCs.
Journal Article
Generation of a functional mammary gland from a single stem cell
Mark Shackleton,François Vaillant,Kaylene J. Simpson,John Stingl,Gordon K. Smyth,Marie Liesse Asselin-Labat,Li Wu,Jane E. Visvader,Geoffrey J. Lindeman +8 more
TL;DR: In this article, the mammary gland can be functionally regenerated in mice by serial transplantation of epithelial fragments, providing evidence for the existence of self-renewing, multipotential mammary stem cells (MaSCs).
Journal ArticleDOI
Purification and unique properties of mammary epithelial stem cells
John Stingl,Peter Eirew,Ian Ricketson,Mark Shackleton,François Vaillant,David H. Choi,Haiyan I. Li,Connie J. Eaves,Connie J. Eaves +8 more
TL;DR: The use of multi-parameter cell sorting and limiting dilution transplant analysis is reported to demonstrate the purification of a rare subset of adult mouse mammary cells that are able individually to regenerate an entire mammary gland within 6 weeks in vivo while simultaneously executing up to ten symmetrical self-renewal divisions.
Journal ArticleDOI
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
Elgene Lim,Elgene Lim,François Vaillant,Di Wu,Di Wu,Natasha C. Forrest,Bhupinder Pal,Adam H. Hart,Marie Liesse Asselin-Labat,David E. Gyorki,David E. Gyorki,Teresa Ward,Audrey Partanen,Frank Feleppa,Lily I. Huschtscha,Heather Thorne,Stephen B. Fox,Max Yan,Juliet D. French,Melissa A. Brown,Gordon K. Smyth,Jane E. Visvader,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Geoffrey J. Lindeman +24 more
TL;DR: It is found that breast tissue from BRCA1 mutation carriers harbors an expanded luminal progenitor population that shows factor-independent growth in vitro, and the findings suggest that an aberrant luminalprogenitor population is a target for transformation in BRCa1-associated basal tumors.
Journal ArticleDOI
Control of mammary stem cell function by steroid hormone signalling
Marie Liesse Asselin-Labat,François Vaillant,Julie Sheridan,Bhupinder Pal,Di Wu,Di Wu,Evan R. Simpson,Hisataka Yasuda,Gordon K. Smyth,Gordon K. Smyth,T. John Martin,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Jane E. Visvader,Jane E. Visvader +15 more
TL;DR: It is demonstrated that mouse mammary stem cells (MaSCs) are highly responsive to steroid hormone signalling, despite lacking the oestrogen and progesterone receptors, and indicates that breast cancer chemoprevention may be achieved, in part, through suppression of MaSC function.