F
Françoise Valensi
Researcher at Necker-Enfants Malades Hospital
Publications - 103
Citations - 10803
Françoise Valensi is an academic researcher from Necker-Enfants Malades Hospital. The author has contributed to research in topics: Leukemia & Gene rearrangement. The author has an hindex of 41, co-authored 103 publications receiving 10427 citations. Previous affiliations of Françoise Valensi include French Institute of Health and Medical Research & Paris Descartes University.
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Journal ArticleDOI
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.
Salima Hacein-Bey-Abina,C von Kalle,C von Kalle,Manfred Schmidt,Matthew P. McCormack,NM Wulffraat,Philippe Leboulch,Annick Lim,Cameron S. Osborne,R. Pawliuk,Estelle Morillon,R. Sorensen,A. Forster,Peter Fraser,Jeffrey I. Cohen,G de Saint Basile,Ian E. Alexander,Uwe Wintergerst,Thierry Frebourg,Alain Aurias,Dominique Stoppa-Lyonnet,Serge Romana,I. Radford-Weiss,Fabian Gross,Françoise Valensi,Eric Delabesse,Elizabeth Macintyre,F. Sigaux,Jean Soulier,L. E. Leiva,Manuela Wissler,Claudia Prinz,Terence H. Rabbitts,F. Le Deist,Alain Fischer,Marina Cavazzana-Calvo +35 more
TL;DR: Retrovirus vector insertion can trigger deregulated premalignant cell proliferation with unexpected frequency, most likely driven by retrovirus enhancer activity on the LMO2 gene promoter.
Journal ArticleDOI
NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3)
TL;DR: In vitro and in vivo studies suggest that all-trans retinoic acid (RA) treatment restores cell maturation, and the first permanent cell line with t(15;17), derived from the marrow of a patient with APL in relapse is isolated.
Journal ArticleDOI
Regression of Splenic Lymphoma with Villous Lymphocytes after Treatment of Hepatitis C Virus Infection
Olivier Hermine,François Lefrère,Jean-Pierre Bronowicki,Xavier Mariette,Katayoun Jondeau,Virginie Eclache-Saudreau,Béatrice Delmas,Françoise Valensi,Patrice Cacoub,Christian Bréchot,Bruno Varet,Xavier Troussard +11 more
TL;DR: In patients with splenic lymphoma with villous lymphocytes who are infected with HCV, treatment with interferon can lead to regression of the lymphoma.
Journal ArticleDOI
Caspase Activation Is Required for Terminal Erythroid Differentiation
Yael Zermati,Carmen Garrido,Sophie Amsellem,Serge Fishelson,Didier Bouscary,Françoise Valensi,Bruno Varet,Bruno Varet,Eric Solary,Olivier Hermine,Olivier Hermine +10 more
TL;DR: It is shown that caspase inhibitors arrest the maturation of human erythroid progenitors at early stages of differentiation, before nucleus and chromatin condensation, which indicates a new function for caspases as key proteases in the process of erythroblast differentiation.
Journal ArticleDOI
Clinical and biologic features of CD4(+)CD56(+) malignancies.
Jean Feuillard,Marie-Christine Jacob,Françoise Valensi,Marc Maynadié,Remy Gressin,Laurence Chaperot,Christine Arnoulet,Françoise Brignole-Baudouin,Bernard Drenou,Eliane Duchayne,Annie Falkenrodt,Richard Garand,Emanuelle Homolle,Bernard Husson,Emilienne Kuhlein,Geneviève Le Calvez,Danielle Sainty,Marie-France Sotto,Franck Trimoreau,Marie-Christine Béné +19 more
TL;DR: The conclusion is made that CD4(+)CD56(+) malignancies constitute a genuine homogeneous entity and some therapeutic options were clearly identified.