F
Frank B. Hu
Researcher at Harvard University
Publications - 1784
Citations - 295051
Frank B. Hu is an academic researcher from Harvard University. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 250, co-authored 1675 publications receiving 253464 citations. Previous affiliations of Frank B. Hu include Southwest University & Brigham and Women's Hospital.
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Journal ArticleDOI
A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk
Alisa K. Manning,Alisa K. Manning,Heather M. Highland,Heather M. Highland,Jessica A. Gasser,Xueling Sim,Taru Tukiainen,Taru Tukiainen,Pierre Fontanillas,Niels Grarup,Manuel A. Rivas,Anubha Mahajan,Adam E. Locke,Pablo Cingolani,Tune H. Pers,Ana Viñuela,Ana Viñuela,Andrew A. Brown,Andrew A. Brown,Ying Wu,Jason Flannick,Jason Flannick,Christian Fuchsberger,Eric R. Gamazon,Kyle J. Gaulton,Kyle J. Gaulton,Hae Kyung Im,Tanya M. Teslovich,Thomas W. Blackwell,Jette Bork-Jensen,Noël P. Burtt,Yuhui Chen,Todd Green,Christopher Hartl,Hyun Min Kang,Ashok Kumar,Ashok Kumar,Claes Ladenvall,Clement Ma,Loukas Moutsianas,Richard D. Pearson,John R. B. Perry,John R. B. Perry,John R. B. Perry,N. William Rayner,N. William Rayner,N. William Rayner,Neil R. Robertson,Neil R. Robertson,Laura J. Scott,Martijn van de Bunt,Martijn van de Bunt,Johan G. Eriksson,Antti Jula,Seppo Koskinen,Terho Lehtimäki,Aarno Palotie,Aarno Palotie,Aarno Palotie,Olli T. Raitakari,Olli T. Raitakari,Suzanne B.R. Jacobs,Jennifer Wessel,Audrey Y. Chu,Robert A. Scott,Mark O. Goodarzi,Christine Blancher,Gemma Buck,David Buck,Peter S. Chines,Stacey Gabriel,Anette P. Gjesing,Christopher J. Groves,Mette Hollensted,Jeroen R. Huyghe,Anne U. Jackson,Goo Jun,Johanne Marie Justesen,Massimo Mangino,Jacquelyn Murphy,Matt J. Neville,Robert C. Onofrio,Kerrin S. Small,Heather M. Stringham,Joseph Trakalo,Eric Banks,Jason Carey,Mauricio O. Carneiro,Mark A. DePristo,Yossi Farjoun,Timothy Fennell,Jacqueline I. Goldstein,Jacqueline I. Goldstein,George B. Grant,Martin Hrabé de Angelis,Jared Maguire,Benjamin M. Neale,Benjamin M. Neale,Ryan Poplin,Shaun Purcell,Shaun Purcell,Shaun Purcell,Thomas Schwarzmayr,Khalid Shakir,Joshua D. Smith,Tim M. Strom,Thomas Wieland,Jaana Lindström,Ivan Brandslund,Cramer Christensen,Gabriela L. Surdulescu,Timo A. Lakka,Alex S. F. Doney,Peter M. Nilsson,Nicholas J. Wareham,Claudia Langenberg,Tibor V. Varga,Paul W. Franks,Paul W. Franks,Paul W. Franks,Olov Rolandsson,Anders Rosengren,Vidya S. Farook,Farook Thameem,Sobha Puppala,Satish Kumar,Donna M. Lehman,Christopher P. Jenkinson,Joanne E. Curran,Daniel E. Hale,Sharon P. Fowler,Rector Arya,Ralph A. DeFronzo,Hanna E. Abboud,Ann-Christine Syvänen,Pamela J. Hicks,Nicholette D. Palmer,Maggie C.Y. Ng,Donald W. Bowden,Barry I. Freedman,Tõnu Esko,Reedik Mägi,Lili Milani,Evelin Mihailov,Andres Metspalu,Narisu Narisu,Leena Kinnunen,Lori L. Bonnycastle,Amy J. Swift,Dorota Pasko,Andrew R. Wood,João Fadista,Toni I. Pollin,Nir Barzilai,Gil Atzmon,Benjamin Glaser,Barbara Thorand,Konstantin Strauch,Annette Peters,Michael Roden,Martina Müller-Nurasyid,Liming Liang,Jennifer Kriebel,Thomas Illig,Harald Grallert,Christian Gieger,Christa Meisinger,Lars Lannfelt,Solomon K. Musani,Michael Griswold,Herman A. Taylor,Gregory A Wilson,Adolfo Correa,Heikki Oksa,William R. Scott,Uzma Afzal,Sian-Tsung Tan,Marie Loh,Marie Loh,Marie Loh,John C. Chambers,John C. Chambers,John C. Chambers,Jobanpreet Sehmi,Jaspal S. Kooner,Benjamin Lehne,Yoon Shin Cho,Jong-Young Lee,Bok-Ghee Han,Annemari Käräjämäki,Qibin Qi,Qibin Qi,Lu Qi,Lu Qi,Jinyan Huang,Frank B. Hu,Olle Melander,Marju Orho-Melander,Jennifer E. Below,David Aguilar,Tien Yin Wong,Jianjun Liu,Jianjun Liu,Chiea Chuen Khor,Kee Seng Chia,Wei-Yen Lim,Ching-Yu Cheng,Edmund Chan,E. Shyong Tai,Tin Aung,Allan Linneberg,Allan Linneberg,Bo Isomaa,Thomas Meitinger,Tiinamaija Tuomi,Liisa Hakaste,Jasmina Kravic,Marit E. Jørgensen,Torsten Lauritzen,Panos Deloukas,Kathleen Stirrups,Kathleen Stirrups,Katharine R. Owen,Andrew Farmer,Timothy M. Frayling,Stephen O'Rahilly,Mark Walker,Jonathan C. Levy,Dylan Hodgkiss,Andrew T. Hattersley,Teemu Kuulasmaa,Alena Stančáková,Inês Barroso,Inês Barroso,Dwaipayan Bharadwaj,Juliana C.N. Chan,Giriraj R. Chandak,Mark J. Daly,Peter Donnelly,Peter Donnelly,Shah Ebrahim,Paul Elliott,Tasha E. Fingerlin,Philippe Froguel,Cheng Hu,Weiping Jia,Ronald C.W. Ma,Gilean McVean,Taesung Park,Dorairaj Prabhakaran,Manjinder S. Sandhu,Manjinder S. Sandhu,James Scott,Robert Sladek,Nikhil Tandon,Yik Ying Teo,Eleftheria Zeggini,Richard M. Watanabe,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Y. Antero Kesäniemi,Matti Uusitupa,Tim D. Spector,Veikko Salomaa,Rainer Rauramaa,Colin N. A. Palmer,Inga Prokopenko,Inga Prokopenko,Inga Prokopenko,Andrew D. Morris,Richard N. Bergman,Francis S. Collins,Lars Lind,Erik Ingelsson,Jaakko Tuomilehto,Fredrik Karpe,Leif Groop,Torben Jørgensen,Torben Jørgensen,Torben Hansen,Torben Hansen,Oluf Pedersen,Johanna Kuusisto,Gonçalo R. Abecasis,Graeme I. Bell,John Blangero,Nancy J. Cox,Ravindranath Duggirala,Mark Seielstad,Mark Seielstad,James G. Wilson,Josée Dupuis,Samuli Ripatti,Samuli Ripatti,Craig L. Hanis,Jose C. Florez,Karen L. Mohlke,James B. Meigs,James B. Meigs,Markku Laakso,Andrew P. Morris,Andrew P. Morris,Andrew P. Morris,Michael Boehnke,David Altshuler,Mark I. McCarthy,Mark I. McCarthy,Anna L. Gloyn,Anna L. Gloyn,Cecilia M. Lindgren,Cecilia M. Lindgren,Cecilia M. Lindgren +312 more
TL;DR: The allelic spectrum for coding variants in AKT2 associated with disorders of glucose homeostasis is extended and bidirectional effects of variants within the pleckstrin homology domain ofAKT2 are demonstrated.
Journal ArticleDOI
Exogenous Hormone Use: Oral Contraceptives, Postmenopausal Hormone Therapy, and Health Outcomes in the Nurses' Health Study.
Shilpa N Bhupathiraju,Francine Grodstein,Meir J. Stampfer,Walter C. Willett,Frank B. Hu,JoAnn E. Manson +5 more
TL;DR: Findings from the NHS and a recent analysis of the Women's Health Initiative indicate that younger women who are closer to menopause onset have a more favorable risk-benefit profile than do older women from use of hormone therapy for relief of vasomotor symptoms.
Journal ArticleDOI
Effects of Genetic and Nongenetic Factors on Total and Bioavailable 25(OH)D Responses to Vitamin D Supplementation.
Pang Yao,Liang Sun,Ling Lu,Hong Ding,Xiafei Chen,Lixin Tang,Xinming Xu,Gang Liu,Yao Hu,Yiwei Ma,Feijie Wang,Qianlu Jin,He Zheng,Huiyong Yin,Rong Zeng,Yan Chen,Frank B. Hu,Huaixing Li,Xu Lin +18 more
TL;DR: In this article, the authors investigated factors modifying 25-hydroxyvitamin D (25[OH]D) and bioavailable 25(OH)D (25 [OH]DBio) responses after vitamin D3 supplementation.
Journal ArticleDOI
Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies
Adela Hruby,Julius S. Ngwa,Frida Renström,Frida Renström,Frida Renström,Mary K. Wojczynski,Andrea Ganna,Göran Hallmans,Denise K. Houston,Paul F. Jacques,Stavroula Kanoni,Stavroula Kanoni,Terho Lehtimäki,Rozenn N. Lemaitre,Ani Manichaikul,Kari E. North,Ioanna Ntalla,Emily Sonestedt,Toshiko Tanaka,Frank J. A. van Rooij,Stefania Bandinelli,Luc Djoussé,Efi Grigoriou,Ingegerd Johansson,Kurt Lohman,James S. Pankow,Olli T. Raitakari,Ulf Risérus,Mary Yannakoulia,M. Carola Zillikens,Neelam Hassanali,Yongmei Liu,Dariush Mozaffarian,Constantina Papoutsakis,Ann-Christine Syvänen,André G. Uitterlinden,Jorma Viikari,Christopher J. Groves,Albert Hofman,Lars Lind,Mark I. McCarthy,Mark I. McCarthy,Vera Mikkilä,Kenneth J. Mukamal,Oscar H. Franco,Ingrid B. Borecki,L. Adrienne Cupples,George Dedoussis,Luigi Ferrucci,Frank B. Hu,Erik Ingelsson,Mika Kähönen,W. H. Linda Kao,Stephen B. Kritchevsky,Marju Orho-Melander,Inga Prokopenko,Inga Prokopenko,Jerome I. Rotter,David S. Siscovick,Jacqueline C.M. Witteman,Paul W. Franks,Paul W. Franks,Paul W. Franks,James B. Meigs,Nicola M. McKeown,Jennifer A. Nettleton +65 more
TL;DR: No magnesium-related SNP or interaction between any SNP and magnesium reached significance after correction for multiple testing, but nominal evidence of TRPM6 influence and magnesium interaction with select loci suggests that further investigation is warranted.
Journal ArticleDOI
Peroxisome Proliferator-Activated Receptor-γ2 P12A Polymorphism and Risk of Coronary Heart Disease in US Men and Women
Tobias Pischon,Jennifer K. Pai,JoAnn E. Manson,Frank B. Hu,Kathryn M. Rexrode,David G. Hunter,Eric B. Rimm +6 more
TL;DR: These data do not support the hypothesis that the A12 allele is associated with a decreased risk of CHD, and the potential interaction between PPARG2 P12A, overweight, and increased CHD risk needs further evaluation.