Author
Frank H Wiley
Bio: Frank H Wiley is an academic researcher from Food and Drug Administration. The author has contributed to research in topics: Pharmacopoeia. The author has an hindex of 1, co-authored 1 publications receiving 29 citations.
Topics: Pharmacopoeia
Papers
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TL;DR: Diclofenac association with ultradeformable carriers permits it to have a longer effect and to reach 10-times higher concentrations in the tissues under the skin in comparison with the drug from a commercial hydrogel, suggesting that dicl ofenac in Transfersomes has the potential to replace combined oral/topical dic lofenacs administration in humans.
359 citations
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TL;DR: Topical corticosteroid delivery with very deformable vesicles, Transfersomes, thus improves the therapeutic risk-benefit ratio, arguably due to better targeting into and longer drug presence in the skin.
217 citations
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TL;DR: The biological anti-edema activity of transfersomal corticosteroid formulations hence exceeds that of the corresponding commercial products, probably owing to the superior drug-targeting potential in the organ.
187 citations
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TL;DR: Novel formulations of the halogenated corticosteroid, triamcinolone-acetonide, based on ultradeformable mixed lipid vesicles, Transfersomes, are described, and their performance was tested in vivo using radioactive label measurements, to study the drug biodistribution, and murine ear edema, to determine the drug bioactivity.
146 citations
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06 Jul 1982TL;DR: In this paper, the eucalyptol acts as a unique transport agent which readily delivers the active bio-affecting agent across the stratum corneum to the target area.
Abstract: Greatly enhanced delivery of a wide variety of bio-affecting agents is provided by formulations for topical application comprising at least one bio-affecting agent and eucalyptol. Optionally, the formulation can further comprise a non-toxic topical carrier and/or an additional penetration enhancer. The eucalyptol acts as a unique transport agent which readily delivers the active bio-affecting agent across the stratum corneum to the target area. Cosmetic and therapeutic dermatological agents as well as systemically effective therapeutic agents can be easily formulated with eucalyptol and effectively delivered through the skin to the desired site, i.e., to the underlying tissues of the epidermis and dermis or to the general circulation.
107 citations