F
Frank L. Heppner
Researcher at German Center for Neurodegenerative Diseases
Publications - 236
Citations - 24068
Frank L. Heppner is an academic researcher from German Center for Neurodegenerative Diseases. The author has contributed to research in topics: Microglia & Medicine. The author has an hindex of 66, co-authored 206 publications receiving 19068 citations. Previous affiliations of Frank L. Heppner include University of Amsterdam & Charité.
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Journal ArticleDOI
DNA methylation-based classification of central nervous system tumours
David Capper,David Capper,David Capper,David T.W. Jones,Martin Sill,Volker Hovestadt,Daniel Schrimpf,Daniel Schrimpf,Dominik Sturm,Dominik Sturm,Christian Koelsche,Christian Koelsche,Felix Sahm,Felix Sahm,Lukas Chavez,David E. Reuss,David E. Reuss,Annekathrin Kratz,Annekathrin Kratz,Annika K. Wefers,Annika K. Wefers,Kristin Huang,Kristin Huang,Kristian W. Pajtler,Kristian W. Pajtler,Leonille Schweizer,Leonille Schweizer,Damian Stichel,Damian Stichel,Adriana Olar,Nils W. Engel,Nils W. Engel,Kerstin Lindenberg,Patrick N. Harter,Patrick N. Harter,Anne K. Braczynski,Anne K. Braczynski,Karl H. Plate,Karl H. Plate,Hildegard Dohmen,Boyan K. Garvalov,Roland Coras,Annett Hölsken,Ekkehard Hewer,Melanie Bewerunge-Hudler,Matthias Schick,Roger Fischer,Rudi Beschorner,Jens Schittenhelm,Ori Staszewski,Khalida Wani,Pascale Varlet,Mélanie Pagès,Petra Temming,Dietmar R. Lohmann,Florian Selt,Florian Selt,Hendrik Witt,Hendrik Witt,Till Milde,Till Milde,Olaf Witt,Olaf Witt,Eleonora Aronica,Felice Giangaspero,Elisabeth J. Rushing,Wolfram Scheurlen,Christoph Geisenberger,Christoph Geisenberger,Fausto J. Rodriguez,Albert J. Becker,Matthias Preusser,Christine Haberler,Rolf Bjerkvig,Jane Cryan,Michael A. Farrell,Martina Deckert,Jürgen Hench,Stephan Frank,Jonathan Serrano,Kasthuri Kannan,Aristotelis Tsirigos,Wolfgang Brück,Silvia Hofer,Stefanie Brehmer,Marcel Seiz-Rosenhagen,Daniel Hänggi,Volkmar Hans,Stephanie Rozsnoki,Jordan R. Hansford,Patricia Kohlhof,Bjarne Winther Kristensen,Matt Lechner,Beatriz Lopes,Christian Mawrin,Ralf Ketter,Andreas E. Kulozik,Ziad Khatib,Frank L. Heppner,Arend Koch,Anne Jouvet,Catherine Keohane,Helmut Mühleisen,Wolf Mueller,Ute Pohl,Marco Prinz,Axel Benner,Marc Zapatka,Nicholas G. Gottardo,Nicholas G. Gottardo,Pablo Hernáiz Driever,Christof M. Kramm,Hermann L. Müller,Stefan Rutkowski,Katja von Hoff,Michael C. Frühwald,Astrid Gnekow,Gudrun Fleischhack,Stephan Tippelt,Gabriele Calaminus,Camelia-Maria Monoranu,Arie Perry,Chris Jones,Thomas S. Jacques,Bernhard Radlwimmer,Marco Gessi,Torsten Pietsch,Johannes Schramm,Gabriele Schackert,Manfred Westphal,Guido Reifenberger,Guido Reifenberger,Pieter Wesseling,Pieter Wesseling,Michael Weller,Vincent Peter Collins,Ingmar Blümcke,Martin Bendszus,Jürgen Debus,Annie Huang,Nada Jabado,Paul A. Northcott,Werner Paulus,Amar Gajjar,Giles W. Robinson,Michael D. Taylor,Zane Jaunmuktane,Marina Ryzhova,Michael Platten,Andreas Unterberg,Wolfgang Wick,Matthias A. Karajannis,Michel Mittelbronn,Till Acker,Christian Hartmann,Kenneth Aldape,Ulrich Schüller,Ulrich Schüller,Rolf Buslei,Peter Lichter,Marcel Kool,Christel Herold-Mende,David W. Ellison,Martin Hasselblatt,Matija Snuderl,Sebastian Brandner,Andrey Korshunov,Andrey Korshunov,Andreas von Deimling,Andreas von Deimling,Stefan M. Pfister,Stefan M. Pfister +171 more
TL;DR: This work presents a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and shows that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods.
Journal ArticleDOI
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
Susanne Krasemann,Susanne Krasemann,Charlotte Madore,Ron Cialic,Caroline Baufeld,Narghes Calcagno,Rachid El Fatimy,Lien Beckers,Elaine O’Loughlin,Yang Xu,Zain Fanek,David J. Greco,Scott T. Smith,George Tweet,Zachary Humulock,Tobias Zrzavy,Patricia Conde-Sanroman,Mar Gacias,Zhiping Weng,Hao Chen,Emily C. Tjon,Fargol Mazaheri,Kristin Hartmann,Asaf Madi,Jason D. Ulrich,Markus Glatzel,Anna Worthmann,Joerg Heeren,Bogdan Budnik,Cynthia A. Lemere,Tsuneya Ikezu,Frank L. Heppner,Vladimir Litvak,David M. Holtzman,Hans Lassmann,Howard L. Weiner,Jordi Ochando,Christian Haass,Oleg Butovsky +38 more
TL;DR: The TREM2-APOE pathway is identified as a major regulator of microglial functional phenotype in neurodegenerative diseases and serves as a novel target that could aid in the restoration of homeostatic microglia.
Journal ArticleDOI
Immune attack: the role of inflammation in Alzheimer disease
TL;DR: As inflammation in AD primarily concerns the innate immune system — unlike in 'typical' neuroinflammatory diseases such as multiple sclerosis and encephalitides — the concept of neuroinflammation in AD may need refinement.
Journal ArticleDOI
Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19.
Jenny Meinhardt,Josefine Radke,Carsten Dittmayer,Jonas Franz,Jonas Franz,Carolina Thomas,Carolina Thomas,Ronja Mothes,Michael Laue,Julia Schneider,Sebastian Brünink,Selina Greuel,Malte Lehmann,Olga Hassan,Tom Aschman,Elisa Schumann,Robert Lorenz Chua,Christian Conrad,Roland Eils,Roland Eils,Werner Stenzel,Marc Windgassen,Larissa Rößler,Hans-Hilmar Goebel,Hans R. Gelderblom,Hubert Martin,Andreas Nitsche,Walter J. Schulz-Schaeffer,Samy Hakroush,Martin Sebastian Winkler,Björn Tampe,Franziska Scheibe,Peter Körtvelyessy,Peter Körtvelyessy,Dirk Reinhold,Britta Siegmund,Anja A. Kühl,Sefer Elezkurtaj,David Horst,Lars Oesterhelweg,Michael Tsokos,Barbara Ingold-Heppner,Christine Stadelmann,Christian Drosten,Victor M. Corman,Helena Radbruch,Frank L. Heppner +46 more
TL;DR: The morphological changes associated with infection such as thromboembolic ischemic infarction of the CNS and evidence of SARS-CoV-2 neurotropism are described and presented.
Journal ArticleDOI
Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.
Melanie Greter,Frank L. Heppner,Maria P. Lemos,Bernhard M Odermatt,Norbert Goebels,Terri M. Laufer,Randolph J. Noelle,Burkhard Becher +7 more
TL;DR: It is shown that APCs of the lymphoreticular system and of the CNS parenchyma are dispensable for the immune invasion of the central nervous system (CNS) and that a discrete population of vessel-associated dendritic cells (DCs) is present in human brain tissue.