F
Frank McKeon
Researcher at University of Houston
Publications - 154
Citations - 31678
Frank McKeon is an academic researcher from University of Houston. The author has contributed to research in topics: Stem cell & Calcineurin. The author has an hindex of 74, co-authored 151 publications receiving 30024 citations. Previous affiliations of Frank McKeon include Harvard University & National University of Singapore.
Papers
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Journal ArticleDOI
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
Annie Yang,Ronen Schweitzer,Deqin Sun,Mourad Kaghad,Nancy Walker,Roderick T. Bronson,Clifford J. Tabin,Arlene H. Sharpe,Daniel Caput,Christopher P. Crum,Frank McKeon +10 more
TL;DR: It is reported that mice homozygous for a disrupted p63 gene have major defects in their limb, craniofacial and epithelial development, and results indicate that p63 is critical for maintaining the progenitor-cell populations that are necessary to sustain epithelialDevelopment and morphogenesis.
Journal ArticleDOI
p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.
Annie Yang,Mourad Kaghad,Yunmei Wang,Emily Gillett,Mark D. Fleming,Mark D. Fleming,Mark D. Fleming,Volker Dötsch,Nancy C. Andrews,Nancy C. Andrews,Daniel Caput,Frank McKeon +11 more
TL;DR: The cloning of p63, a gene at chromosome 3q27-29 that bears strong homology to the tumor suppressor p53 and to the related gene, p73, is described and the possibility of physiological interactions among members of the p53 family is suggested.
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Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers.
Mourad Kaghad,Helene Bonnet,Annie Yang,Laurent Creancier,Jean-Christophe Biscan,A. Valent,Adrian Minty,Pascale Chalon,Jean-Michel Lelias,Xavier Dumont,Pascual Ferrara,Frank McKeon,Daniel Caput +12 more
TL;DR: The demonstration that p73 is monoallelically expressed supports the notion that it is a candidate gene in neuroblastoma and proposes that the disregulation of p73 contributes to tumorigenesis and that p53-related proteins operate in a network of developmental and cell cycle controls.
Journal ArticleDOI
p63 identifies keratinocyte stem cells
Graziella Pellegrini,Elena Dellambra,Osvaldo Golisano,Enrica Martinelli,Ivana Fantozzi,Sergio Bondanza,Diego Ponzin,Frank McKeon,Michele De Luca +8 more
TL;DR: It is shown by clonal analysis that p63 is abundantly expressed by epidermal and limbal holoclones, but is undetectable in paraclones, and will be of practical importance for the clinical application of epithelial cultures in cell therapy as well as for studies on epithelial tumorigenesis.
Journal ArticleDOI
Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.
Hong Gang Wang,Nuzhat Pathan,Iryna M. Ethell,Stanislaw Krajewski,Yu Yamaguchi,Futoshi Shibasaki,Frank McKeon,Tanya Bobo,Thomas F. Franke,John C. Reed +9 more
TL;DR: In hippocampal neurons, L-glutamate triggered mitochondrial targeting of BAD and apoptosis, which were both suppressible by coexpression of a dominant-inhibitory mutant of calcineurin or pharmacological inhibitors of this phosphatase.