F
Frank X. Gu
Researcher at University of Toronto
Publications - 156
Citations - 13474
Frank X. Gu is an academic researcher from University of Toronto. The author has contributed to research in topics: Nanoparticle & Drug delivery. The author has an hindex of 45, co-authored 147 publications receiving 12077 citations. Previous affiliations of Frank X. Gu include University of Alberta & Massachusetts Institute of Technology.
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Journal ArticleDOI
Nanoparticles in Medicine: Therapeutic Applications and Developments
TL;DR: Nanomaterials have unique physicochemical properties, such as ultra small size, large surface area to mass ratio, and high reactivity, which are different from bulk materials of the same composition, which can be used to overcome some of the limitations found in traditional therapeutic and diagnostic agents.
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Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery
Jianjun Cheng,Benjamin A. Teply,Benjamin A. Teply,Ines Sherifi,Ines Sherifi,Josephine Sung,Gaurav Luther,Frank X. Gu,Etgar Levy-Nissenbaum,Etgar Levy-Nissenbaum,Aleksandar Filip Radovic-Moreno,Robert Langer,Omid C. Farokhzad,Omid C. Farokhzad +13 more
TL;DR: It is found that NP mean volumetric size correlates linearly with polymer concentration for NPs between 70 and 250 nm in diameter and the ability to control NP size together with targeted delivery may result in favorable biodistribution and development of clinically relevant targeted therapies.
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Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA–PEG nanoparticles
Shanta Dhar,Frank X. Gu,Robert Langer,Omid C. Farokhzad,Omid C. Farokhzad,Stephen J. Lippard +5 more
TL;DR: A unique strategy to deliver cisplatin to prostate cancer cells by constructing Pt(IV)-encapsulated prostate-specific membrane antigen (PSMA) targeted nanoparticles (NPs) of poly(D,L-lactic-co-glycolic acid) (PLGA)-poly(ethylene glycol) (PEG)-functionalized controlled release polymers is reported.
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Self-assembled lipid--polymer hybrid nanoparticles: a robust drug delivery platform.
Liangfang Zhang,Juliana M. Chan,Frank X. Gu,June-Wha Rhee,Andrew Z. Wang,Andrew Z. Wang,Aleksandar Filip Radovic-Moreno,Frank Alexis,Frank Alexis,Robert Langer,Omid C. Farokhzad +10 more
TL;DR: The engineering of a novel lipid-polymer hybrid nanoparticle (NP) as a robust drug delivery platform, with high drug encapsulation yield, tunable and sustained drug release profile, excellent serum stability, and potential for differential targeting of cells or tissues is reported.
Journal ArticleDOI
Microfluidic Platform for Controlled Synthesis of Polymeric Nanoparticles
Rohit Karnik,Frank X. Gu,Pamela Basto,Christopher Cannizzaro,Lindsey Dean,William Kyei-Manu,Robert Langer,Omid C. Farokhzad +7 more
TL;DR: This work used rapid and tunable mixing through hydrodynamic flow focusing in microfluidic channels to control nanoprecipitation of poly(lactic- co-glycolic acid)- b-poly(ethylene glycol) diblock copolymers as a model polymeric biomaterial for drug delivery.