F
Franklin H. Epstein
Researcher at Harvard University
Publications - 60
Citations - 11736
Franklin H. Epstein is an academic researcher from Harvard University. The author has contributed to research in topics: Kidney & Renal function. The author has an hindex of 26, co-authored 60 publications receiving 11066 citations. Previous affiliations of Franklin H. Epstein include University of Massachusetts Medical School & University of Maryland, Baltimore.
Papers
More filters
Journal ArticleDOI
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
Sharon Maynard,Jiang Yong Min,Jaime R. Merchan,Kee-Hak Lim,Jianyi Li,Susanta Mondal,Towia A. Libermann,James P. Morgan,Frank W. Sellke,Isaac E. Stillman,Franklin H. Epstein,Vikas P. Sukhatme,S. Ananth Karumanchi +12 more
TL;DR: It is confirmed that placental soluble fms-like tyrosine kinase 1 (sFlt1), an antagonist of VEGF and placental growth factor (PlGF), is upregulated in preeclampsia, leading to increased systemic levels of sFlt 1 that fall after delivery, and observations suggest that excess circulating sFelt1 contributes to the pathogenesis of preeClampsia.
Journal ArticleDOI
Circulating Angiogenic Factors and the Risk of Preeclampsia
Richard J. Levine,Sharon Maynard,Cong Qian,Kee-Hak Lim,Lucinda England,Kai F. Yu,Enrique F. Schisterman,Ravi Thadhani,Benjamin P. Sachs,Franklin H. Epstein,Bahaeddine M Sibai,Vikas P. Sukhatme,S. Ananth Karumanchi +12 more
TL;DR: Alterations in the levels of sFlt-1 and free PlGF were greater in women with an earlier onset of preeclampsia and in women in whom preeClampsia was associated with a small-for-gestational-age infant.
Journal ArticleDOI
Soluble endoglin and other circulating antiangiogenic factors in preeclampsia.
Richard J. Levine,Chun Lam,Cong Qian,Kai F. Yu,Sharon Maynard,Benjamin P. Sachs,Baha M. Sibai,Franklin H. Epstein,Roberto Romero,Roberto Romero,Ravi Thadhani,S. Ananth Karumanchi +11 more
TL;DR: Rising circulating levels of soluble endoglin and ratios of sFlt1:PlGF herald the onset of preeclampsia, which was greatest among women in the highest quartile of the control distributions for both biomarkers but not for either biomarker alone.
Journal ArticleDOI
Renal ischemia: a new perspective.
Journal ArticleDOI
Noninvasive Evaluation of Intrarenal Oxygenation With BOLD MRI
TL;DR: BOLD MRI can be used to monitor changes in intrarenal oxygenation in humans in a noninvasive fashion and demonstrates the feasibility of such a method on the basis of blood oxygenation level-dependent (BOLD) MRI.