F
Frans H.M. Corstens
Researcher at Radboud University Nijmegen Medical Centre
Publications - 177
Citations - 8667
Frans H.M. Corstens is an academic researcher from Radboud University Nijmegen Medical Centre. The author has contributed to research in topics: Radioimmunotherapy & Biodistribution. The author has an hindex of 51, co-authored 177 publications receiving 8399 citations. Previous affiliations of Frans H.M. Corstens include Radboud University Nijmegen & Bristol-Myers Squibb.
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Journal Article
Accelerated Blood Clearance and Altered Biodistribution of Repeated Injections of Sterically Stabilized Liposomes
E.T.M. Dams,Peter Laverman,Wim J.G. Oyen,Gert Storm,Gerrit L. Scherphof,Jos W. M. van der Meer,Frans H.M. Corstens,Otto C. Boerman +7 more
TL;DR: Administration of sterically stabilized PEG liposomes significantly altered the pharmacokinetic behavior of subsequently injected PEGliposomes in a time- and frequency-dependent manner, and the observed phenomenon may have important implications for the repeated administration of sterially stabilized liposome for targeted drug delivery.
Journal Article
Tumor targeting with radiolabeled alpha(v)beta(3) integrin binding peptides in a nude mouse model.
M. L. Janssen,Wim J.G. Oyen,Ingrid Dijkgraaf,Leon F.A.G. Massuger,Cathelijne Frielink,D. Scott Edwards,Milind Rajopadhye,H. Boonstra,Frans H.M. Corstens,Otto C. Boerman +9 more
TL;DR: The radiolabeled RGD peptides (111)In-DOTA-E-[c(RGDfK)](2) and (99m)Tc-HYNIC-E '[c(Gly-Asp]F]], demonstrated high and specific tumor uptake in a human tumor xenograft.
Journal ArticleDOI
Clinical value of FDG PET in patients with fever of unknown origin and patients suspected of focal infection or inflammation.
Chantal P. Bleeker-Rovers,Elisabeth M. H. A. de Kleijn,Frans H.M. Corstens,Jos W. M. van der Meer,Wim J.G. Oyen +4 more
TL;DR: FDG PET appears to be a valuable imaging technique in the evaluation of FUO and suspected focal infection or inflammation and could become a useful tool for evaluating the effect of treatment of infectious and inflammatory processes that cannot reliably be visualised by conventional techniques.
Journal Article
Pretargeted Radioimmunotherapy of Cancer: Progress Step by Step
TL;DR: In bispecific antibody-based pretargeting strategies, the use of bivalent haptens improved the efficacy of the tumor targeting, and a 2-step pretargeted radioimmunotherapy strategy is now being tested in cancer patients.
Journal ArticleDOI
Reflex sympathetic dystrophy of the hand: an excessive inflammatory response?
Wim J.G. Oyen,Ivo E. Arntz,Roland A. M. J. Claessens,Jos W. M. van der Meer,Frans H.M. Corstens,R. Jan A. Goris +5 more
TL;DR: Increased vascular permeability for macromolecules, an important characteristic of inflammation, appears to play a role in the development of RSD.