Franz-Xaver Reichl

TL;DR: Genotoxic and cytotoxic effects of three common methacrylates are investigated in human samples of salivary glands and peripheral lymphocytes and evidence of a possible risk factor for tumor initiation in human salivARY glands is given.

TL;DR: In higher concentration levels, all tested substances induced significant but minor enhancement of DNA migration in the Comet assay as a possible sign for limited genotoxic effects, however, with the highest levels ofDNA migration being combined with elevated cytotoxicity effects, a low in vivo genotoxicity strain appears to be posed by the resin components.

TL;DR: It is shown for the first time that exposure to dental resin monomers can induce DSBs in primary human oral cavity cells, which underscores their genotoxic capacity.

TL;DR: BisGMA induced a significant high embryotoxic/teratogenic effect over a large range of concentration, and attention should be focused on this dental monomer, which should be investigated further by in vivo experiments.

TL;DR: The results of this study indicate that resin composite components have a lower toxicity than mercury from amalgam in HGF, indicating that other (additional) factors may be involved in the induction of tissue (pulp) inflammation effects after dental restauration.