F
Franziska Kappenberg
Researcher at Technical University of Dortmund
Publications - 7
Citations - 171
Franziska Kappenberg is an academic researcher from Technical University of Dortmund. The author has contributed to research in topics: Cytotoxicity & Incubation period. The author has an hindex of 3, co-authored 7 publications receiving 91 citations.
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Journal ArticleDOI
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
Wiebke Albrecht,Franziska Kappenberg,Tim Brecklinghaus,Regina Stoeber,Rosemarie Marchan,Mian Zhang,Kristina E Ebbert,Hendrik Kirschner,Marianna Grinberg,Marianna Grinberg,Marcel Leist,Wolfgang Moritz,Cristina Cadenas,Ahmed Ghallab,Ahmed Ghallab,Jörg Reinders,Nachiket Vartak,Christoph van Thriel,Klaus Golka,Laia Tolosa,José V. Castell,Georg Damm,Georg Damm,Daniel Seehofer,Daniel Seehofer,Alfonso Lampen,Albert Braeuning,Thorsten Buhrke,Anne Cathrin Behr,Axel Oberemm,Xiaolong Gu,Naim Kittana,Bob van de Water,Reinhard Kreiling,Susann Fayyaz,Leon van Aerts,Bård Smedsrød,Heidrun Ellinger-Ziegelbauer,Thomas Steger-Hartmann,Ursula Gundert-Remy,Anja Zeigerer,Anett Ullrich,Dieter Runge,Serene M. L. Lee,Tobias S. Schiergens,Lars Kuepfer,Alejandro Aguayo-Orozco,Agapios Sachinidis,Karolina Edlund,Iain Gardner,Jörg Rahnenführer,Jan G. Hengstler +51 more
TL;DR: An in vitro/in silico method was established that predicts the risk of human DILI in relation to oral doses and blood concentrations of test compounds to the probability of hepatotoxicity and application to the rat hepatotoxicant pulegone resulted in an ADI similar to values previously established based on animal experiments.
Journal ArticleDOI
Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes.
Xiaolong Gu,Xiaolong Gu,Wiebke Albrecht,Karolina Edlund,Franziska Kappenberg,Jörg Rahnenführer,Marcel Leist,Wolfgang Moritz,Patricio Godoy,Cristina Cadenas,Rosemarie Marchan,Tim Brecklinghaus,Laia Tolosa Pardo,José V. Castell,Iain Gardner,Bo Han,Jan G. Hengstler,Regina Stoeber +17 more
TL;DR: The median cytotoxicity of the test compounds increased between 1 and 2 days of incubation, with no or only a minimal further increase until day 7, and it remains to be studied whether the different results obtained for some individual compounds after longer exposure periods would correspond better to human-repeated dose toxicity.
Journal ArticleDOI
Spatio-Temporal Multiscale Analysis of Western Diet-Fed Mice Reveals a Translationally Relevant Sequence of Events during NAFLD Progression.
Ahmed Ghallab,Ahmed Ghallab,Maiju Myllys,Adrian Friebel,Julia Duda,Karolina Edlund,Emina Halilbasic,Mihael Vucur,Zaynab Hobloss,Lisa Brackhagen,Brigitte Begher-Tibbe,Reham Hassan,Reham Hassan,Michael Burke,Erhan Genç,Lynn Johann Frohwein,Ute Hofmann,Christian H. Holland,Daniela González,Magdalena Keller,Abdel-latif Seddek,Tahany Abbas,Elsayed S. I. Mohammed,Andreas Teufel,Timo Itzel,Sarah Metzler,Rosemarie Marchan,Cristina Cadenas,Carsten Watzl,Michael A. Nitsche,Franziska Kappenberg,Tom Luedde,Thomas Longerich,Jörg Rahnenführer,Stefan Hoehme,Michael Trauner,Jan G. Hengstler +36 more
TL;DR: In this paper, a sequence of eight key events were identified: formation of lipid droplets; inflammatory foci; lipogranulomas; zonal reorganization; cell death and replacement proliferation; ductular reaction; fibrogenesis; and hepatocellular cancer.
Journal ArticleDOI
Determination of benchmark concentrations and their statistical uncertainty for cytotoxicity test data and functional in vitro assays.
Alice Krebs,Johanna Nyffeler,Christiaan Karreman,Béla Z. Schmidt,Franziska Kappenberg,Jan Mellert,Giorgia Pallocca,Manuel Pastor,Jörg Rahnenführer,Marcel Leist +9 more
TL;DR: A user-friendly, web-based tool (BMCeasy), designed for operators without programming skills and profound statistical background, to determine BMCs and their confidence intervals, which was used within the EU-ToxRisk project for preparing data packages that were submitted to regulatory authorities.
Journal ArticleDOI
The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds.
Tim Brecklinghaus,Wiebke Albrecht,Franziska Kappenberg,Julia Duda,Nachiket Vartak,Karolina Edlund,Rosemarie Marchan,Ahmed Ghallab,Cristina Cadenas,Georgia Günther,Marcel Leist,Mian Zhang,Iain Gardner,Jörg Reinders,Frans G. M. Russel,Alison J. Foster,Dominic P. Williams,Amruta Damle-Vartak,Melanie Grandits,Gerhard F. Ecker,Naim Kittana,Jörg Rahnenführer,Jan G. Hengstler +22 more
TL;DR: In this paper, an export assay for 5-chloromethylfluorescein diacetate (CMFDA) was established, and the toxicity separation index (TSI) was calculated to quantify if the addition of the CMFDA assay to the existing test system improves the overall separation of hepatotoxic from non-hepatotoxic compounds.