Healthy biological systems exhibit complex patterns of variability that can be described by mathematical chaos. Heart rate variability (HRV) consists of changes in the time intervals between consecutive heartbeats called interbeat intervals (IBIs). A healthy heart is not a metronome. The oscillations of a healthy heart are complex and constantly changing, which allow the cardiovascular system to rapidly adjust to sudden physical and psychological challenges to homeostasis. This article briefly reviews current perspectives on the mechanisms that generate 24 h, short-term (~5 min), and ultra-short-term (<5 min) HRV, the importance of HRV, and its implications for health and performance. The authors provide an overview of widely-used HRV time-domain, frequency-domain, and non-linear metrics. Time-domain indices quantify the amount of HRV observed during monitoring periods that may range from ~2 min to 24 h. Frequency-domain values calculate the absolute or relative amount of signal energy within component bands. Non-linear measurements quantify the unpredictability and complexity of a series of IBIs. The authors survey published normative values for clinical, healthy, and optimal performance populations. They stress the importance of measurement context, including recording period length, subject age, and sex, on baseline HRV values. They caution that 24 h, short-term, and ultra-short-term normative values are not interchangeable. They encourage professionals to supplement published norms with findings from their own specialized populations. Finally, the authors provide an overview of HRV assessment strategies for clinical and optimal performance interventions.

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An Overview of Heart Rate Variability Metrics and Norms.

Heart rate variability (HRV), the change in the time intervals between adjacent heartbeats, is an emergent property of interdependent regulatory systems that operate on different time scales to adapt to challenges and achieve optimal performance. This article briefly reviews neural regulation of the heart, and its basic anatomy, the cardiac cycle, and the sinoatrial and atrioventricular pacemakers. The cardiovascular regulation center in the medulla integrates sensory information and input from higher brain centers, and afferent cardiovascular system inputs to adjust heart rate and blood pressure via sympathetic and parasympathetic efferent pathways. This article reviews sympathetic and parasympathetic influences on the heart, and examines the interpretation of HRV and the association between reduced HRV, risk of disease and mortality, and the loss of regulatory capacity. This article also discusses the intrinsic cardiac nervous system and the heart-brain connection, through which afferent information can influence activity in the subcortical and frontocortical areas, and motor cortex. It also considers new perspectives on the putative underlying physiological mechanisms and properties of the ultra-low-frequency (ULF), very-low-frequency (VLF), low-frequency (LF), and high-frequency (HF) bands. Additionally, it reviews the most common time and frequency domain measurements as well as standardized data collection protocols. In its final section, this article integrates Porges’ polyvagal theory, Thayer and colleagues’ neurovisceral integration model, Lehrer et al.’s resonance frequency model, and the Institute of HeartMath’s coherence model. The authors conclude that a coherent heart is not a metronome because its rhythms are characterized by both complexity and stability over longer time scales. Future research should expand understanding of how the heart and its intrinsic nervous system influence the brain.

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A healthy heart is not a metronome: an integrative review of the heart's anatomy and heart rate variability.

Psychophysiological research integrating heart rate variability (HRV) has increased during the last two decades, particularly given the fact that HRV is able to index cardiac vagal tone. Vagal tone, which represents the activity of the parasympathetic system, is acknowledged to be linked with many phenomena relevant for psychophysiological research, including self-regulation at the cognitive, emotional, social, and health levels. The ease of HRV collection and measurement coupled with the fact it is relatively affordable, non-invasive and pain free makes it widely accessible to many researchers. This ease of access should not obscure the difficulty of interpretation of HRV findings that can be easily misconstrued, however this can be controlled to some extent through correct methodological processes. Standards of measurement were developed two decades ago by a Task Force within HRV research, and recent reviews updated several aspects of the Task Force paper. However, many methodological aspects related to HRV in psychophysiological research have to be considered if one aims to be able to draw sound conclusions, which makes it difficult to interpret findings and to compare results across laboratories. Those methodological issues have mainly been discussed in separate outlets, making difficult to get a grasp on them, and thus this paper aims to address this issue. It will help to provide psychophysiological researchers with recommendations and practical advice concerning experimental designs, data analysis, and data reporting. This will ensure that researchers starting a project with HRV and cardiac vagal tone are well informed regarding methodological considerations in order for their findings to contribute to knowledge advancement in their field.

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Heart Rate Variability and Cardiac Vagal Tone in Psychophysiological Research - Recommendations for Experiment Planning, Data Analysis, and Data Reporting.

Heart rate variability, the change in the time intervals between adjacent heartbeats, is an emergent property of interdependent regulatory systems that operates on different time scales to adapt to environmental and psychological challenges. This article briefly reviews neural regulation of the heart and offers some new perspectives on mechanisms underlying the very low frequency rhythm of heart rate variability. Interpretation of heart rate variability rhythms in the context of health risk and physiological and psychological self-regulatory capacity assessment is discussed. The cardiovascular regulatory centers in the spinal cord and medulla integrate inputs from higher brain centers with afferent cardiovascular system inputs to adjust heart rate and blood pressure via sympathetic and parasympathetic efferent pathways. We also discuss the intrinsic cardiac nervous system and the heart-brain connection pathways, through which afferent information can influence activity in the subcortical, frontocortical, and motor cortex areas. In addition, the use of real-time HRV feedback to increase self-regulatory capacity is reviewed. We conclude that the heart's rhythms are characterized by both complexity and stability over longer time scales that reflect both physiological and psychological functional status of these internal self-regulatory systems.

Heart Rate Variability: New Perspectives on Physiological Mechanisms, Assessment of Self-regulatory Capacity, and Health risk.

Instructions This exam consists of 50 questions. You may write on the exam itself, but be sure to answer all your questions on a “Scantron” sheet with a #2 pencil. For each question there is one response that is the best response. You must select the one best response to receive credit for each question. If you select more than one response for a question, then you will receive no credit for that question.

人体の解剖生理学 = Human anatomy & physiology

Heart rate variability (HRV) is the fluctuation in time between successive heartbeats and is defined by interbeat intervals. Researchers have shown that short-term (∼5-min) and long-term (≥24-h) HRV measurements are associated with adaptability, health, mobilization, and use of limited regulatory resources, and performance. Long-term HRV recordings predict health outcomes heart attack, stroke, and all-cause mortality. Despite the prognostic value of long-term HRV assessment, it has not been broadly integrated into mainstream medical care or personal health monitoring. Although short-term HRV measurement does not require ambulatory monitoring and the cost of long-term assessment, it is underutilized in medical care. Among the diverse reasons for the slow adoption of short-term HRV measurement is its prohibitive time cost (∼5 min). Researchers have addressed this issue by investigating the criterion validity of ultra-short-term (UST) HRV measurements of less than 5-min duration compared with short-term recordings. The criterion validity of a method indicates that a novel measurement procedure produces comparable results to a currently validated measurement tool. We evaluated 28 studies that reported UST HRV features with a minimum of 20 participants; of these 17 did not investigate criterion validity and 8 primarily used correlational and/or group difference criteria. The correlational and group difference criteria were insufficient because they did not control for measurement bias. Only three studies used a limits of agreement (LOA) criterion that specified a priori an acceptable difference between novel and validated values in absolute units. Whereas the selection of rigorous criterion validity methods is essential, researchers also need to address such issues as acceptable measurement bias and control of artifacts. UST measurements are proxies of proxies. They seek to replace short-term values which, in turn, attempt to estimate long-term metrics. Further adoption of UST HRV measurements requires compelling evidence that these metrics can forecast real-world health or performance outcomes. Furthermore, a single false heartbeat can dramatically alter HRV metrics. UST measurement solutions must automatically edit artifactual interbeat interval values otherwise HRV measurements will be invalid. These are the formidable challenges that must be addressed before HRV monitoring can be accepted for widespread use in medicine and personal health care.

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A Critical Review of Ultra-Short-Term Heart Rate Variability Norms Research.

Heart rate variability (HRV) is generated by the interaction of multiple regulatory mechanisms that operate on different time scales. This article examines the regulation of the heart, the meaning of HRV, Thayer and Lane's neurovisceral integration model, the sources of HRV, HRV frequency and time domain measurements, Porges's polyvagal theory, and resonance frequency breathing. The medical implications of HRV biofeedback for cardiovascular rehabilitation and inflammatory disorders are considered.

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Fred Shaffer

Papers

An Overview of Heart Rate Variability Metrics and Norms.

A healthy heart is not a metronome: an integrative review of the heart's anatomy and heart rate variability.

Heart Rate Variability: New Perspectives on Physiological Mechanisms, Assessment of Self-regulatory Capacity, and Health risk.

A Critical Review of Ultra-Short-Term Heart Rate Variability Norms Research.

Heart Rate Variability Anatomy and Physiology