Frederick M. Boyce

TL;DR: Immunohistochemistry in human and rat brain revealed widespread cytoplasmic labeling of huntingtin within neurons, rather than the more selective pattern of axon terminal labeling characteristic of many vesicle-associated proteins.

TL;DR: Using oligonucleotide primer sequences that can be used to amplify eight exons plus the muscle promoter of the dystrophin gene in a single multiplex polymerase chain reaction (PCR) will allow deletion detection and prenatal diagnosis for most DMD/BMD patients in a fraction of the time required for Southern blot analysis.

TL;DR: Porcine endothelial cells expressing recombinant beta-galactosidase from a murine amphotropic retroviral vector were introduced with a catheter into denuded iliofemoral arteries of syngeneic animals, indicating that they were successfully implanted on the vessel wall.

TL;DR: This paper describes the use of the baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) as a vector for gene delivery into mammalian cells and finds it may be a useful vector for genetic manipulation of liver cells.

TL;DR: A flexible and modular approach is used to target intersectionally specified populations of inhibitory interneurons in mammalian hippocampus and neurons of the ventral tegmental area defined by both genetic and wiring properties, which may expand the application of genetically encoded interventional and observational tools for intact-systems biology.