Frederick P. Siegal

TL;DR: Purified IPCs are here shown to be the CD4(+)CD11c- type 2 dendritic cell precursors (pDC2s), which produce 200 to 1000 times more IFN than other blood cells after microbial challenge and are thus an effector cell type of the immune system, critical for antiviral and antitumor immune responses.

TL;DR: The data suggest that the AIDS virus affects a subset of LGL, and that cytokine production by these cells is an important component of the host defense against intracellular pathogens that becomes crucial in the presence of severe T cell immunodeficiency.

TL;DR: The findings suggest that long-lived systemic cellular antiviral immunity as detected by assays is not a common mechanism for resistance to infection, and that resistance may be multifactorial.

TL;DR: The data indicate that HTLV‐I lymphoma, while uncommon, is not necessarily rare among other‐than‐low‐grade NHL cases in the United States and, given its poor prognosis, should probably be studied separately in clinical trials.

TL;DR: Most patients with severe combined immunodeficiency disease (SCID) and deficits of both T- and B-cell function demonstrated normal NK function with one or both targets, and patients with Bruton's agammaglobulinemia demonstratednormal NK and interferon generation.