F
Frederik Dethloff
Researcher at Max Planck Society
Publications - 23
Citations - 605
Frederik Dethloff is an academic researcher from Max Planck Society. The author has contributed to research in topics: Autophagy & Metabolite. The author has an hindex of 10, co-authored 20 publications receiving 358 citations.
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Journal ArticleDOI
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.
Nils C. Gassen,Jan Papies,Jan Papies,Thomas Bajaj,Jackson Emanuel,Jackson Emanuel,Frederik Dethloff,Robert Lorenz Chua,Jakob Trimpert,Nicolas Heinemann,Nicolas Heinemann,Christine Niemeyer,Friderike Weege,Friderike Weege,Katja Hönzke,Tom Aschman,Daniel E. Heinz,Katja Weckmann,Tim Ebert,Andreas Zellner,M. Lennarz,Emanuel Wyler,Simon Schroeder,Simon Schroeder,Anja Richter,Anja Richter,Daniela Niemeyer,Daniela Niemeyer,Karen Hoffmann,Thomas F. Meyer,Frank L. Heppner,Frank L. Heppner,Victor M. Corman,Victor M. Corman,Markus Landthaler,Markus Landthaler,Andreas C. Hocke,Markus Morkel,Markus Morkel,Nikolaus Osterrieder,Nikolaus Osterrieder,Christian Conrad,Roland Eils,Roland Eils,Helena Radbruch,Patrick Giavalisco,Christian Drosten,Christian Drosten,Marcel A. Müller +48 more
TL;DR: In this paper, the authors show that SARS-CoV-2 infection modulates cellular metabolism and limits autophagy, and identify druggable host pathways for virus inhibition.
Posted ContentDOI
Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics
Nils C. Gassen,Jan Papies,Jan Papies,Thomas Bajaj,Frederik Dethloff,Jackson Emanuel,Jackson Emanuel,Katja Weckmann,Daniel E. Heinz,Nicolas Heinemann,Nicolas Heinemann,M. Lennarz,Anja Richter,Anja Richter,Daniela Niemeyer,Daniela Niemeyer,Victor M. Corman,Victor M. Corman,Patrick Giavalisco,Christian Drosten,Christian Drosten,Marcel A. Müller,Marcel A. Müller +22 more
TL;DR: It is shown that SARS-CoV-2 infection limits autophagy by interfering with multiple metabolic pathways and that compound-driven interventions aimed at Autophagy induction reduce Sars-Cov-2 propagation in vitro.
Journal ArticleDOI
Systems analysis of ethanol production in the genetically engineered cyanobacterium Synechococcus sp. PCC 7002.
Joachim Kopka,Stefanie Schmidt,Frederik Dethloff,Nadin Pade,Susanne Berendt,Marco Schottkowski,Nico Martin,Ulf Dühring,Ekaterina Kuchmina,Heike Enke,Dan Kramer,Annegret Wilde,Martin Hagemann,Alexandra Friedrich +13 more
TL;DR: Systems analysis of ethanol production in Synechococcus sp.
Journal ArticleDOI
Ketamine’s antidepressant effect is mediated by energy metabolism and antioxidant defense system
Katja Weckmann,Katja Weckmann,Michael J. Deery,Julie Howard,Renata Feret,John M. Asara,Frederik Dethloff,Michaela D. Filiou,Jamie Iannace,Christiana Labermaier,Giuseppina Maccarrone,Christian Webhofer,Larysa Teplytska,Kathryn S. Lilley,Marianne B. Müller,Christoph W. Turck +15 more
TL;DR: It is suggested that ketamine causes less protein damage by rapidly decreasing reactive oxygen species (ROS) production and lend further support to the hypothesis that mitochondria have a critical role for mediating antidepressant action including the rapid ketamine response.
Journal ArticleDOI
Insights into isoprene production using the cyanobacterium Synechocystis sp. PCC 6803
Nadin Pade,Sabrina Erdmann,Heike Enke,Frederik Dethloff,Ulf Dühring,Jens Georg,Juliane Wambutt,Joachim Kopka,Wolfgang R. Hess,Ralf Zimmermann,Dan Kramer,Martin Hagemann +11 more
TL;DR: This work reports on attempts to generate isoprene-producing strains of Synechocystis using a plasmid-based strategy and reveals the upregulation of mRNA and regulatory RNAs characteristic of acclimation to metabolic stress in cyanobacterial hosts.