F
Frédérique Végran
Researcher at French Institute of Health and Medical Research
Publications - 74
Citations - 6037
Frédérique Végran is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Immune system & Cancer. The author has an hindex of 28, co-authored 60 publications receiving 4932 citations. Previous affiliations of Frédérique Végran include University of Burgundy & Université catholique de Louvain.
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Journal ArticleDOI
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
Pierre Sonveaux,Frédérique Végran,Thies Schroeder,Melanie Wergin,Julien Verrax,Zahid N. Rabbani,Christophe De Saedeleer,Kelly M. Kennedy,Caroline Diepart,Bénédicte F. Jordan,Michael J. Kelley,Bernard Gallez,Miriam L. Wahl,Olivier Feron,Mark W. Dewhirst +14 more
TL;DR: In this paper, the authors identified monocarboxylate transporter 1 (MCT1) as the prominent path for lactate uptake by a human cervix squamous carcinoma cell line that preferentially utilized lactate for oxidative metabolism.
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Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth
Mélanie Bruchard,Grégoire Mignot,Grégoire Mignot,Valentin Derangère,Valentin Derangère,Fanny Chalmin,Fanny Chalmin,Angélique Chevriaux,Angélique Chevriaux,Frédérique Végran,Frédérique Végran,Wilfrid Boireau,Benoit Simon,Bernhard Ryffel,Jean Louis Connat,Jean Kanellopoulos,François Martin,François Martin,Cédric Rébé,Cédric Rébé,Lionel Apetoh,Lionel Apetoh,François Ghiringhelli,François Ghiringhelli +23 more
TL;DR: How activation of the Nlrp3 inflammasome in MDSCs by 5FU and Gem limits the antitumor efficacy of these chemotherapeutic agents is identified.
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Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis.
TL;DR: The findings establish a signaling role for lactate in endothelial cells and they identify the lactate/NF-κB/IL-8 pathway as an important link between tumor metabolism and angiogenesis.
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Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.
Pierre Sonveaux,Pierre Sonveaux,Tamara Copetti,Christophe De Saedeleer,Frédérique Végran,Julien Verrax,Kelly M. Kennedy,Eui Jung Moon,Suveera Dhup,Pierre Danhier,Françoise Frérart,Bernard Gallez,Anthony T. Ribeiro,Carine Michiels,Mark W. Dewhirst,Olivier Feron +15 more
TL;DR: This study finds that blockade of lactate influx into ECs led to inhibition of HIF-1-dependent angiogenesis and identifies MCT1 inhibition as a therapeutic modality combining antimetabolic and anti-angiogenic activities.
Journal ArticleDOI
The receptor NLRP3 is a transcriptional regulator of TH2 differentiation.
Mélanie Bruchard,Cédric Rébé,Valentin Derangère,Dieudonnée Togbe,Bernhard Ryffel,Romain Boidot,Etienne Humblin,Arlette Hamman,Fanny Chalmin,Hélène Berger,Angélique Chevriaux,Emeric Limagne,Lionel Apetoh,Frédérique Végran,François Ghiringhelli +14 more
TL;DR: The results demonstrate the ability of NLRP3 to act as a key transcription factor in TH2 differentiation and specifically supported a T helper type 2 (TH2) transcriptional program in a cell-intrinsic manner.