Human-induced pluripotent stem cells (hiPSCs) and CRISPR/Cas9 gene editing system represent two instruments of basic and translational research, which both allow to acquire deep insight about the molecular bases of many diseases but also to develop pharmacological researchThis review is focused to draw up the latest technique of gene editing applied on hiPSCs, exploiting some of the genetic manipulation directed to the discovery of innovative therapeutic strategies There are many expediencies provided by the use of hiPSCs, which can represent a disease model clinically relevant and predictive, with a great potential if associated to CRISPR/Cas9 technology, a gene editing tool powered by ease and precision never seen beforeHere, we describe the possible applications of CRISPR/Cas9 to hiPSCs: from drug development to drug screening and from gene therapy to the induction of the immunological response to specific virus infection, such as HIV and SARS-Cov-2

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Application of CRISPR/Cas9 to human-induced pluripotent stem cells: from gene editing to drug discovery.

This paper examines the diverse cultural composition in Europe and how it poses great potential and challenge for marketers in the region Multicultural Marketing practice in Europe is still at a very early stage and the diverse ethnic markets are at the present largely untapped Using United Kingdom as a case, the paper provides some guidelines for marketers targeting ethnic minorities in Europe

The Marketing Challenge of Multiculturalism: An Exploratory Study

Male infertility is evaluated throughout the quantitative and qualitative analysis of male’s semen and the sperm contained therein. One of the most essential part of this process is the evaluation of the cytomorphology of man’s semen.

/pdf/biobanks-and-clinical-research-an-interesting-connection-i7psxs9cfg.pdf

Biobanks and Clinical Research: An “Interesting” Connection

The existence of vacant land is a worldwide phenomenon. However, few studies have used quantitative methods to focus on the micro-level drivers that cause land to remain vacant in small towns. In t...

Urban vacant land in rapidly urbanized areas: Status, micro-level drivers, and implications

Local Impacts, Global Crisis: Analyzing Global Climate-Change Impacts at the Local Level in Maine

Biobanks are structures used for the preservation of biological samples. These repositories store biospecimens for short or long period of time, depending on the aim for which they are employed. The collections stored inside consist of different types and for each material there's a specific protocol to be followed, in order to keep sample in the best condition as possible. So, a good state is a primary hallmark and its basic to have a well-protected specimen to obtain reliable results fit for clinical purposes and research. In the last years, medical sciences are developing together with the progress of knowledge and skills: the need for new answer to questions about rare and common diseases has greatly contributed to the creation of a network of biobanks which cooperate in Europe and internationally to discover new findings. Therefore, the importance of biobanks is currently considerable. In this article, the topic of biobanks is argued by reviewing the most relevant aspects of these centers. Due to the strategic role of biobanks, the debate on their management and policy is focused on a variety of issues with the aim of reaching a shared agreement and obtaining a universal concordance. Only so, it will possible to achieve and maintain unity and create homogeneous system of biobanking.

https://www.graphyonline.com/archives/IJLMR/2015/IJLMR-106/article.pdf

More than just a

Toward the Future: The New Challenges of the Cell Therapy and Potential of Regenerative Medicine

Diabetes mellitus is a very common disease that affects a large number of people in the world and whose treatment is very expensive, also due to its complications.

/pdf/diabetes-mellitus-and-regenerative-medicine-new-acqv8o38nu.pdf

Fulvia Fraticelli

Papers

More than just a

Toward the Future: The New Challenges of the Cell Therapy and Potential of Regenerative Medicine

Diabetes Mellitus and Regenerative Medicine: New Possibilities for the Regeneration of β Cells and Treatment of Diabetic Foot Ulcer