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Furuya Toshiyuki

Bio: Furuya Toshiyuki is an academic researcher. The author has contributed to research in topics: Glycidic acid & Alkyl. The author has an hindex of 1, co-authored 1 publications receiving 1 citations.

Papers
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Patent
31 Jul 1991
TL;DR: In this article, a racemic trans-3-phenyl glycidic acid of formula I (the ring A is phenyl capable of being substituted) including the compound having one or more substituents on the phenyl group is reacted with an alkanol (preferably a 2-8C alcohol such as methanol) in the presence of a hydrolase (e.g. a lipase originated from Candida cylindracea) to esterify either of a (2S,3R) isomer and a ( 2R
Abstract: PURPOSE:To obtain the subject compound as highly pure crystals useful as an intermediate for optically active benzothiazepines by a single process comprising reacting racemic trans-phenylglycidic acid with an alkanol in the presence of a hydrolase. CONSTITUTION:A racemic trans-3-phenylglycidic acid of formula I (the ring A is phenyl capable of being substituted) including the compound having one or more substituents on the phenyl group is reacted with an alkanol (preferably a 2-8C alcohol such as methanol) in the presence of a hydrolase (e.g. a lipase originated from Candida cylindracea) to esterify either of a (2S,3R) isomer and a (2R,3S) isomer, and the produced optically active ester of formula II (R is alkyl) is separated and collected. The esterification reaction is preferably performed in toluene, carbon tetrachlorocarbon, etc., as a solvent under an anhydrous condition at 30-40 deg.C. The racemic compound as the raw material is preferably racemic trans-3-(4-methylphenyl)glycidic acid.

1 citations


Cited by
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Patent
27 Feb 1998
TL;DR: In this article, a process for preparing an optically active trans-3-substituted glycidic acid ester compound of the formula (I) is described.
Abstract: A process for preparing an optically active trans-3-substituted glycidic acid ester compound of the formula (I): ##STR1## wherein ring A is a substituted or unsubstituted benzene ring, and R1 is an ester residue, which comprises: preparing a solution of one optical isomer (A) and the other optical isomer (B) of the ester compound (I), both of which are the optical isomers due to the asymmetric carbons at 2- and 3-positions, and an ester compound (B') which is different from the isomer (B) only in the ester residue R1, crystallizing the optical isomer (A) from the solution up to the extent that the optical isomer (A) is crystallized without the precipitation of the optical isomer (B) due to the presence of the ester compound (B') though the optical isomer (B) would precipitate if the ester compound (B') were not present, and isolating the crystals of the optical isomer (A), whereby a desired optical isomer (A) can be obtained in high purity and in a high yield such that the desired isomer can be crystallized until the concentration of the desired isomer in the mother liquor becomes very low as compared with conventional processes.

7 citations