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Author

G.A.P. Cirrone

Other affiliations: University of Catania, ASTRON
Bio: G.A.P. Cirrone is an academic researcher from Istituto Nazionale di Fisica Nucleare. The author has contributed to research in topics: Proton therapy & Monte Carlo method. The author has an hindex of 31, co-authored 258 publications receiving 10567 citations. Previous affiliations of G.A.P. Cirrone include University of Catania & ASTRON.


Papers
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Journal ArticleDOI
TL;DR: GeGeant4 as mentioned in this paper is a software toolkit for the simulation of the passage of particles through matter, it is used by a large number of experiments and projects in a variety of application domains, including high energy physics, astrophysics and space science, medical physics and radiation protection.
Abstract: Geant4 is a software toolkit for the simulation of the passage of particles through matter. It is used by a large number of experiments and projects in a variety of application domains, including high energy physics, astrophysics and space science, medical physics and radiation protection. Its functionality and modeling capabilities continue to be extended, while its performance is enhanced. An overview of recent developments in diverse areas of the toolkit is presented. These include performance optimization for complex setups; improvements for the propagation in fields; new options for event biasing; and additions and improvements in geometry, physics processes and interactive capabilities

6,063 citations

Journal ArticleDOI
John Allison1, K. Amako2, John Apostolakis3, Pedro Arce4, Makoto Asai5, Tsukasa Aso6, Enrico Bagli, Alexander Bagulya7, Sw. Banerjee8, G. Barrand9, B. R. Beck10, Alexey Bogdanov11, D. Brandt, Jeremy M. C. Brown12, Helmut Burkhardt3, Ph Canal8, D. Cano-Ott4, Stephane Chauvie, Kyung-Suk Cho13, G.A.P. Cirrone14, Gene Cooperman15, M. A. Cortés-Giraldo16, G. Cosmo3, Giacomo Cuttone14, G.O. Depaola17, Laurent Desorgher, X. Dong15, Andrea Dotti5, Victor Daniel Elvira8, Gunter Folger3, Ziad Francis18, A. Galoyan19, L. Garnier9, M. Gayer3, K. Genser8, Vladimir Grichine7, Vladimir Grichine3, Susanna Guatelli20, Susanna Guatelli21, Paul Gueye22, P. Gumplinger23, Alexander Howard24, Ivana Hřivnáčová9, S. Hwang13, Sebastien Incerti25, Sebastien Incerti26, A. Ivanchenko3, Vladimir Ivanchenko3, F.W. Jones23, S. Y. Jun8, Pekka Kaitaniemi27, Nicolas A. Karakatsanis28, Nicolas A. Karakatsanis29, M. Karamitrosi30, M.H. Kelsey5, Akinori Kimura31, Tatsumi Koi5, Hisaya Kurashige32, A. Lechner3, S. B. Lee33, Francesco Longo34, M. Maire, Davide Mancusi, A. Mantero, E. Mendoza4, B. Morgan35, K. Murakami2, T. Nikitina3, Luciano Pandola14, P. Paprocki3, J Perl5, Ivan Petrović36, Maria Grazia Pia, W. Pokorski3, J. M. Quesada16, M. Raine, Maria A.M. Reis37, Alberto Ribon3, A. Ristic Fira36, Francesco Romano14, Giorgio Ivan Russo14, Giovanni Santin38, Takashi Sasaki2, D. Sawkey39, J. I. Shin33, Igor Strakovsky40, A. Taborda37, Satoshi Tanaka41, B. Tome, Toshiyuki Toshito, H.N. Tran42, Pete Truscott, L. Urbán, V. V. Uzhinsky19, Jerome Verbeke10, M. Verderi43, B. Wendt44, H. Wenzel8, D. H. Wright5, Douglas Wright10, T. Yamashita, J. Yarba8, H. Yoshida45 
TL;DR: Geant4 as discussed by the authors is a software toolkit for the simulation of the passage of particles through matter, which is used by a large number of experiments and projects in a variety of application domains, including high energy physics, astrophysics and space science, medical physics and radiation protection.
Abstract: Geant4 is a software toolkit for the simulation of the passage of particles through matter. It is used by a large number of experiments and projects in a variety of application domains, including high energy physics, astrophysics and space science, medical physics and radiation protection. Over the past several years, major changes have been made to the toolkit in order to accommodate the needs of these user communities, and to efficiently exploit the growth of computing power made available by advances in technology. The adaptation of Geant4 to multithreading, advances in physics, detector modeling and visualization, extensions to the toolkit, including biasing and reverse Monte Carlo, and tools for physics and release validation are discussed here.

2,260 citations

Journal ArticleDOI
TL;DR: This work presents a comparative investigation of cell killing RBE variations along monoenergetic and modulated proton beams using human normal and radioresistant cells with the aim to investigate the RBE dependence on LET and intrinsic radiosensitvity and highlights the limitation of adoption of a constant RBE for proton therapy.
Abstract: Purpose The biological optimization of proton therapy can be achieved only through a detailed evaluation of relative biological effectiveness (RBE) variations along the full range of the Bragg curve. The clinically used RBE value of 1.1 represents a broad average, which disregards the steep rise of linear energy transfer (LET) at the distal end of the spread-out Bragg peak (SOBP). With particular attention to the key endpoint of cell survival, our work presents a comparative investigation of cell killing RBE variations along monoenergetic (pristine) and modulated (SOBP) beams using human normal and radioresistant cells with the aim to investigate the RBE dependence on LET and intrinsic radiosensitvity. Methods and Materials Human fibroblasts (AG01522) and glioma (U87) cells were irradiated at 6 depth positions along pristine and modulated 62-MeV proton beams at the INFN-LNS (Catania, Italy). Cell killing RBE variations were measured using standard clonogenic assays and were further validated using Monte Carlo simulations and the local effect model (LEM). Results We observed significant cell killing RBE variations along the proton beam path, particularly in the distal region showing strong dose dependence. Experimental RBE values were in excellent agreement with the LEM predicted values, indicating dose-averaged LET as a suitable predictor of proton biological effectiveness. Data were also used to validate a parameterized RBE model. Conclusions The predicted biological dose delivered to a tumor region, based on the variable RBE inferred from the data, varies significantly with respect to the clinically used constant RBE of 1.1. The significant RBE increase at the distal end suggests also a potential to enhance optimization of treatment modalities such as LET painting of hypoxic tumors. The study highlights the limitation of adoption of a constant RBE for proton therapy and suggests approaches for fast implementation of RBE models in treatment planning.

178 citations

Journal ArticleDOI
19 Oct 2003
TL;DR: The main features of CATANA together with the clinical and dosimetric features will be extensively reported; particularly, will be described the proton beam line, that has been entirely realized at LNS, with all its elements.
Abstract: At the Istituto Nazionale di Fisica Nucleare-Laboratori Nazionali del Sud (INFN-LNS) in Catania, Italy, the first Italian protontherapy facility, named Centro di AdroTerapia e Applicazioni Nucleari Avanzate (CATANA) has been built in collaboration with the University of Catania. It is based on the use of the 62-MeV proton beam delivered by the K=800 Superconducting Cyclotron installed and working at INFN-LNS since 1995. The facility is mainly devoted to the treatment of ocular diseases like uveal melanoma. A beam treatment line in air has been assembled together with a dedicated positioning patient system. The facility has been in operation since the beginning of 2002 and 66 patients have been successfully treated up to now. The main features of CATANA together with the clinical and dosimetric features will be extensively described; particularly, the proton beam line, that has been entirely built at LNS, with all its elements, the experimental transversal and depth dose distributions of the 62-MeV proton beam obtained for a final collimator of 25-mm diameter and the experimental depth dose distributions of a modulated proton beam obtained for the same final collimator. Finally, the clinical results over 1 yr of treatments, describing the features of the treated diseases will be reported.

137 citations

Journal ArticleDOI
TL;DR: The Geant4 toolkit as mentioned in this paper provides a wide set of alternative models to describe the electromagnetic interaction of photons with matter, and the photon cross-sections that are used by the geant4 electromagnetic models have been compared to external reference libraries (NIST, EPDL97, SANDIA) for several elements and compounds.
Abstract: The Geant4 toolkit provides a wide set of alternative models to describe the electromagnetic interaction of photons with matter. The photon cross-sections that are used by the Geant4 electromagnetic models have been compared to external reference libraries (NIST, EPDL97, SANDIA) for several elements and compounds. The agreement of the Geant4 cross-section with the reference data has been quantified by means of statistical analysis. In particular, the cross-sections of all the Geant4 photon models are in statistical agreement with the NIST database, with the exception of Rayleigh scattering. A critical discussion is presented for those cases where a disagreement is found.

132 citations


Cited by
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Journal ArticleDOI
TL;DR: GeGeant4 as mentioned in this paper is a software toolkit for the simulation of the passage of particles through matter, it is used by a large number of experiments and projects in a variety of application domains, including high energy physics, astrophysics and space science, medical physics and radiation protection.
Abstract: Geant4 is a software toolkit for the simulation of the passage of particles through matter. It is used by a large number of experiments and projects in a variety of application domains, including high energy physics, astrophysics and space science, medical physics and radiation protection. Its functionality and modeling capabilities continue to be extended, while its performance is enhanced. An overview of recent developments in diverse areas of the toolkit is presented. These include performance optimization for complex setups; improvements for the propagation in fields; new options for event biasing; and additions and improvements in geometry, physics processes and interactive capabilities

6,063 citations

Journal ArticleDOI
W. B. Atwood1, A. A. Abdo2, A. A. Abdo3, Markus Ackermann4  +289 moreInstitutions (37)
TL;DR: The Large Area Telescope (Fermi/LAT) as mentioned in this paper is the primary instrument on the Fermi Gamma-ray Space Telescope, which is an imaging, wide field-of-view, high-energy gamma-ray telescope, covering the energy range from below 20 MeV to more than 300 GeV.
Abstract: (Abridged) The Large Area Telescope (Fermi/LAT, hereafter LAT), the primary instrument on the Fermi Gamma-ray Space Telescope (Fermi) mission, is an imaging, wide field-of-view, high-energy gamma-ray telescope, covering the energy range from below 20 MeV to more than 300 GeV. This paper describes the LAT, its pre-flight expected performance, and summarizes the key science objectives that will be addressed. On-orbit performance will be presented in detail in a subsequent paper. The LAT is a pair-conversion telescope with a precision tracker and calorimeter, each consisting of a 4x4 array of 16 modules, a segmented anticoincidence detector that covers the tracker array, and a programmable trigger and data acquisition system. Each tracker module has a vertical stack of 18 x,y tracking planes, including two layers (x and y) of single-sided silicon strip detectors and high-Z converter material (tungsten) per tray. Every calorimeter module has 96 CsI(Tl) crystals, arranged in an 8 layer hodoscopic configuration with a total depth of 8.6 radiation lengths. The aspect ratio of the tracker (height/width) is 0.4 allowing a large field-of-view (2.4 sr). Data obtained with the LAT are intended to (i) permit rapid notification of high-energy gamma-ray bursts (GRBs) and transients and facilitate monitoring of variable sources, (ii) yield an extensive catalog of several thousand high-energy sources obtained from an all-sky survey, (iii) measure spectra from 20 MeV to more than 50 GeV for several hundred sources, (iv) localize point sources to 0.3 - 2 arc minutes, (v) map and obtain spectra of extended sources such as SNRs, molecular clouds, and nearby galaxies, (vi) measure the diffuse isotropic gamma-ray background up to TeV energies, and (vii) explore the discovery space for dark matter.

3,666 citations

Journal ArticleDOI
TL;DR: Delphes as mentioned in this paper is a fast-simulation of a multipurpose detector for phenomenological studies, including a track propagation system embedded in a magnetic field, electromagnetic and hadron calorimeters, and a muon identification system.
Abstract: The version 3.0 of the Delphes fast-simulation is presented. The goal of Delphes is to allow the simulation of a multipurpose detector for phenomenological studies. The simulation includes a track propagation system embedded in a magnetic field, electromagnetic and hadron calorimeters, and a muon identification system. Physics objects that can be used for data analysis are then reconstructed from the simulated detector response. These include tracks and calorimeter deposits and high level objects such as isolated electrons, jets, taus, and missing energy. The new modular approach allows for greater flexibility in the design of the simulation and reconstruction sequence. New features such as the particle-flow reconstruction approach, crucial in the first years of the LHC, and pile-up simulation and mitigation, which is needed for the simulation of the LHC detectors in the near future, have also been implemented. The Delphes framework is not meant to be used for advanced detector studies, for which more accurate tools are needed. Although some aspects of Delphes are hadron collider specific, it is flexible enough to be adapted to the needs of electron-positron collider experiments.

2,692 citations

Journal ArticleDOI
John Allison1, K. Amako2, John Apostolakis3, Pedro Arce4, Makoto Asai5, Tsukasa Aso6, Enrico Bagli, Alexander Bagulya7, Sw. Banerjee8, G. Barrand9, B. R. Beck10, Alexey Bogdanov11, D. Brandt, Jeremy M. C. Brown12, Helmut Burkhardt3, Ph Canal8, D. Cano-Ott4, Stephane Chauvie, Kyung-Suk Cho13, G.A.P. Cirrone14, Gene Cooperman15, M. A. Cortés-Giraldo16, G. Cosmo3, Giacomo Cuttone14, G.O. Depaola17, Laurent Desorgher, X. Dong15, Andrea Dotti5, Victor Daniel Elvira8, Gunter Folger3, Ziad Francis18, A. Galoyan19, L. Garnier9, M. Gayer3, K. Genser8, Vladimir Grichine7, Vladimir Grichine3, Susanna Guatelli20, Susanna Guatelli21, Paul Gueye22, P. Gumplinger23, Alexander Howard24, Ivana Hřivnáčová9, S. Hwang13, Sebastien Incerti25, Sebastien Incerti26, A. Ivanchenko3, Vladimir Ivanchenko3, F.W. Jones23, S. Y. Jun8, Pekka Kaitaniemi27, Nicolas A. Karakatsanis28, Nicolas A. Karakatsanis29, M. Karamitrosi30, M.H. Kelsey5, Akinori Kimura31, Tatsumi Koi5, Hisaya Kurashige32, A. Lechner3, S. B. Lee33, Francesco Longo34, M. Maire, Davide Mancusi, A. Mantero, E. Mendoza4, B. Morgan35, K. Murakami2, T. Nikitina3, Luciano Pandola14, P. Paprocki3, J Perl5, Ivan Petrović36, Maria Grazia Pia, W. Pokorski3, J. M. Quesada16, M. Raine, Maria A.M. Reis37, Alberto Ribon3, A. Ristic Fira36, Francesco Romano14, Giorgio Ivan Russo14, Giovanni Santin38, Takashi Sasaki2, D. Sawkey39, J. I. Shin33, Igor Strakovsky40, A. Taborda37, Satoshi Tanaka41, B. Tome, Toshiyuki Toshito, H.N. Tran42, Pete Truscott, L. Urbán, V. V. Uzhinsky19, Jerome Verbeke10, M. Verderi43, B. Wendt44, H. Wenzel8, D. H. Wright5, Douglas Wright10, T. Yamashita, J. Yarba8, H. Yoshida45 
TL;DR: Geant4 as discussed by the authors is a software toolkit for the simulation of the passage of particles through matter, which is used by a large number of experiments and projects in a variety of application domains, including high energy physics, astrophysics and space science, medical physics and radiation protection.
Abstract: Geant4 is a software toolkit for the simulation of the passage of particles through matter. It is used by a large number of experiments and projects in a variety of application domains, including high energy physics, astrophysics and space science, medical physics and radiation protection. Over the past several years, major changes have been made to the toolkit in order to accommodate the needs of these user communities, and to efficiently exploit the growth of computing power made available by advances in technology. The adaptation of Geant4 to multithreading, advances in physics, detector modeling and visualization, extensions to the toolkit, including biasing and reverse Monte Carlo, and tools for physics and release validation are discussed here.

2,260 citations

Proceedings Article
01 Jan 1994
TL;DR: The main focus in MUCKE is on cleaning large scale Web image corpora and on proposing image representations which are closer to the human interpretation of images.
Abstract: MUCKE aims to mine a large volume of images, to structure them conceptually and to use this conceptual structuring in order to improve large-scale image retrieval. The last decade witnessed important progress concerning low-level image representations. However, there are a number problems which need to be solved in order to unleash the full potential of image mining in applications. The central problem with low-level representations is the mismatch between them and the human interpretation of image content. This problem can be instantiated, for instance, by the incapability of existing descriptors to capture spatial relationships between the concepts represented or by their incapability to convey an explanation of why two images are similar in a content-based image retrieval framework. We start by assessing existing local descriptors for image classification and by proposing to use co-occurrence matrices to better capture spatial relationships in images. The main focus in MUCKE is on cleaning large scale Web image corpora and on proposing image representations which are closer to the human interpretation of images. Consequently, we introduce methods which tackle these two problems and compare results to state of the art methods. Note: some aspects of this deliverable are withheld at this time as they are pending review. Please contact the authors for a preview.

2,134 citations