Author
G. Ariamala
Other affiliations: Indian Institutes of Technology
Bio: G. Ariamala is an academic researcher from Indian Institute of Technology Madras. The author has contributed to research in topics: One-pot synthesis & Claisen rearrangement. The author has an hindex of 2, co-authored 3 publications receiving 31 citations. Previous affiliations of G. Ariamala include Indian Institutes of Technology.
Papers
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TL;DR: In this paper, a one-pot synthesis of 4-chlorochromenes and chroman-4-ones was achieved from γ-chloropropargyl aryl ethers proceeding through Claisen rearrangement, depending upon the solvent of choice.
23 citations
TL;DR: In this article, 3,4-dihydro-3-bromo-4-(prop-2-ynyloxy)-2H-1-benzopyrans (3) undergo radical cyclisation when treated with nBu 3 SnH and AIBN.
8 citations
TL;DR: In this article, a one-pot synthesis of 4-chlorochromenes and chroman-4-ones was achieved from γ-chloropropargyl aryl ethers proceeding through Claisen rearrangement, depending upon the solvent of choice.
Abstract: A one pot synthesis of a number of 4-chlorochromenes and chroman-4-ones was achieved from γ-chloropropargyl aryl ethers proceeding through Claisen rearrangement, depending upon the solvent of choice.
1 citations
Cited by
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TL;DR: Cyclisations cationiques, radicalaires and anioniques as discussed by the authors are catalysees par des metaux, and they can be classified into three classes: cationique, radicalaine and radicalaine.
73 citations
TL;DR: Radical cyclization reactions are among the most powerful and versatile methods for the construction of mono-and polycyclic systems as discussed by the authors, which offer high functional group tolerance and mild reaction conditions combined with high levels of regio- and stereochemistry.
Abstract: Radical cyclization reactions are among the most powerful and versatile methods for the construction of mono- and polycyclic systems. The advantages these reactions offer to the synthetic organic chemist include high functional group tolerance and mild reaction conditions combined with high levels of regio- and stereochemistry. Furthermore, the recent progress in radical chemistry has led to the development of a broad range of very useful practical methods to conduct radical cyclization reactions. In general, radical cyclization reactions comprise three basic steps: selective radical generation, radical cyclization, and conversion of the cyclized radical to the product.
For the generation of the initial radical a broad variety of suitable precursors can be employed, such as halides, thio- and selenoethers, alcohols, aldehydes and hydrocarbons. The cyclization step usually involves the intramolecular addition of a radical to a multiple bond. Most often carbon–carbon multiple bonds are employed; however, there are also examples known for the addition to carbon–oxygen and carbon–nitrogen bonds. Depending on the method employed, the cyclized radical is converted to the desired product by trapping with a radical scavenger, by a fragmentation reaction, or by an electron transfer reaction.
The section Mechanism, Regio- and Stereochemistry provides an introduction to the key features of radical cyclization with a special emphasis on the factors controlling the regio- and stereochemistry. The section Scope and Limitations covers the different methods used to conduct radical cyclization. The basic principles of radical chemistry and general practical considerations when conducting radical cyclizations are not discussed in detail. Several excellent review articles and books dealing with these topics are available.
Keywords:
radical cyclization reactions;
mechanism;
regiochemistry;
steroechemistry;
small rings;
scope;
limitations;
medium-sized rings;
formation;
monocycles;
macrocyclizations;
bi-cycles;
polycycles;
metal hydride;
tin hydride;
mercury hydride;
fragmentation methods;
thiohydroxamine;
methods;
Barton method;
atom transfer;
hydrogen atom transfer;
halogen atom transfer;
radical/radical coupling;
redox methods;
sequential reactions;
experimental conditions;
experimental procedures;
comparison of methods;
tabular survey
58 citations
Patent•
07 Oct 1993TL;DR: In this article, the authors defined a set of compounds having the formula "STR1##" and pharmaceutically acceptable salts thereof, where X is a single bond, O, CO, S, NH or N(lower alkyl); Y is O, S or NCN; and R1 to R5' are as defined herein.
Abstract: Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein X is a single bond, O, CO, S, NH or N(lower alkyl); Y is O, S or NCN; and R1 to R5' are as defined herein. These compounds have potassium channel activating activity and are useful, therefore for example, as cardiovascular agents.
48 citations
Patent•
24 Feb 1992TL;DR: Novel compounds having the formula (See formula I) wherein R1-R9 are as described herein, are useful as antiischemic agents as discussed by the authors. But they are difficult to synthesize.
Abstract: Novel compounds having the formula (See formula I) wherein R1-R9 are as described herein, are useful as antiischemic agents.
46 citations
TL;DR: Novel chroman and tetrahydroquinoline ureas were synthesized and evaluated for their activity as TRPV1 antagonists and it was found that aryl substituents on the 7- or 8-position of both bicyclic scaffolds imparted the best in vitro potency at TRPv1.
44 citations