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G. Buvaneswari

Bio: G. Buvaneswari is an academic researcher from VIT University. The author has contributed to research in topics: Fourier transform infrared spectroscopy & Catalysis. The author has an hindex of 1, co-authored 1 publications receiving 2 citations.

Papers
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Journal ArticleDOI
TL;DR: In this article, an oxyphosphate of formula BiCa4(PO4)3O was prepared and characterized by powder XRD, Fourier transform infrared spectroscopy (FTIR), and SEM-EDAX techniques.
Abstract: An oxyphosphate of formula BiCa4(PO4)3O was prepared and characterized by powder XRD, Fourier transform infrared spectroscopy (FTIR), and SEM-EDAX techniques. The catalytic activity of the synthesized compound was explored in the preparation of 3,4-dihydropyrimidin-2(1H)-one using Biginelli reaction. Influence of parameters such as temperature and solvent on this reaction using this heterogeneous catalyst was studied. A higher yield of 98% of the 3,4-dihydropyrimidin-2(1H)-one was achieved within 120 min of duration at room temperature in the presence of acetic acid (AcOH).

2 citations


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TL;DR: 1, 1'-Sulfinyldiethylammonium bis (hydrogen sulfate), as a novel dicationic ionic liquid, can act as a highly efficient catalyst for the synthesis of 3, 4-dihydropyrimidin-2(1H)-ones under solvent-free conditions.
Abstract: OBJECTIVE A facile and efficient method for synthesis of 3, 4-dihydropyrimidin-2(1H)-ones via Biginelli reaction catalyzed by a novel dicationic Bronsted acidic ionic liquid, [(EtNH2)2SO][HSO4]2, has been successfully developed. MATERIALS AND METHODS 3, 4-Dihydropyrimidin-2(1H)-ones were synthesized through one-pot condensation of aromatic aldehydes, ethyl acetoacetate, and urea under solvent-free conditions using [(EtNH2)2SO][HSO4]2 as a novel catalyst. The progress of the reaction was monitored by thin-layer chromatography (ethyl acetate / n-hexane = 1 / 5). The products have been characterized by IR, 1H NMR, 13C NMR, and also by their melting points. RESULTS In this research, a library of dihydropyrimidinone derivatives was synthesized via Biginelli reaction under solvent-free conditions at 120oC using [(EtNH2)2SO][HSO4]2 as a catalyst. Various aromatic aldehydes, as well as heteroaromatic aldehydes, were employed, affording good to high yields of the corresponding products and illustrating the substrate generality of the present method. In addition, the prepared dicationic Bronsted acidic ionic liquid can be easily recovered and reused. CONCLUSION 1, 1'-Sulfinyldiethylammonium bis (hydrogen sulfate), as a novel dicationic ionic liquid, can act as a highly efficient catalyst for the synthesis of 3, 4-dihydropyrimidin-2(1H)-ones under solvent-free conditions.

3 citations

Book ChapterDOI
01 Jan 2020
TL;DR: In this paper, the authors highlight synthesis of heterocycles using one-pot and multicomponent reactions through a name reaction, which can be considered as an important development in the rational drug design in terms of rapid and unambiguous identification and optimization of biologically active lead compounds.
Abstract: Multicomponent reactions (MCRs) convert more than two molecules straightly to the expected products. Remarkably, a name reaction is a chemical reaction, which has reached to such status from different points of view, being named after its discoverers or developers. Among the tens of thousands of organic reactions that are known, hundreds of such reactions are well-known enough to be named after people. As organic chemistry developed during the 20th century, chemists started associating synthetically useful reactions with the names of the discoverers or developers; in many cases, the name is merely a mnemonic. Since MCRs are one-pot reactions, expectedly, they can be conducted much easier than multistep reactions. Combined, with high-throughput library screening, this protocol can be considered as an important development in the rational drug design in the terms of rapid and unambiguous identification and optimization of biologically active lead compounds. There are several important name reactions in organic chemistry. Among the tens of thousands of organic reactions that are known, hundreds of such reactions have reached such status to be named after its discoverers or developer. Well-known examples include the Biginelli reaction, Hantzsch reaction, Click reaction, Gewald reaction, Ugi reaction, Ugi-azide reaction. Due to importance of name reactions in synthesis of heterocycles, in this chapter, we try to highlight synthesis of heterocycles using one-pot and multicomponent reactions through a name reaction.