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G F Longstreth

Bio: G F Longstreth is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Irritable bowel syndrome & Manning criteria. The author has an hindex of 1, co-authored 1 publications receiving 2489 citations.

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Journal ArticleDOI
01 Sep 1999-Gut
TL;DR: A committee consensus approach, including criticism from multinational expert reviewers, was used to revise the diagnostic criteria and update diagnosis and treatment recommendations, based on research results.
Abstract: The Rome diagnostic criteria for the functional bowel disorders and functional abdominal pain are used widely in research and practice. A committee consensus approach, including criticism from multinational expert reviewers, was used to revise the diagnostic criteria and update diagnosis and treatment recommendations, based on research results. The terminology was clarified and the diagnostic criteria and management recommendations were revised. A functional bowel disorder (FBD) is diagnosed by characteristic symptoms for at least 12 weeks during the preceding 12 months in the absence of a structural or biochemical explanation. The irritable bowel syndrome, functional abdominal bloating, functional constipation, and functional diarrhea are distinguished by symptom-based diagnostic criteria. Unspecified FBD lacks criteria for the other FBDs. Diagnostic testing is individualized, depending on patient age, primary symptom characteristics, and other clinical and laboratory features. Functional abdominal pain (FAP) is defined as either the FAP syndrome, which requires at least six months of pain with poor relation to gut function and loss of daily activities, or unspecified FAP, which lacks criteria for the FAP syndrome. An organic cause for the pain must be excluded, but aspects of the patient's pain behavior are of primary importance. Treatment of the FBDs relies upon confident diagnosis, explanation, and reassurance. Diet alteration, drug treatment, and psychotherapy may be beneficial, depending on the symptoms and psychological features.

2,528 citations


Cited by
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Journal ArticleDOI
TL;DR: Employing a consensus approach, the working team critically considered the available evidence and multinational expert criticism, revised the Rome II diagnostic criteria for the functional bowel disorders, and updated diagnosis and treatment recommendations.

4,302 citations

Journal ArticleDOI
TL;DR: The prevalence of IBS varies among countries, as well as criteria used to define its presence, and women are at slightly higher risk for IBS than men.

1,620 citations

Journal ArticleDOI
TL;DR: This introductory article sets the stage for the remaining 17 articles that follow and offers an historical overview of the FGIDs field, differentiates FGIDs from motility and structural disorders, discusses the changes from Rome III, reviews the Rome committee process, and provides a biopsychosocial pathophysiological conceptualization of FGIDs.

1,406 citations

Journal ArticleDOI
TL;DR: B infantis 35624 alleviates symptoms in IBS; this symptomatic response was associated with normalization of the ratio of an anti-inflammatory to a proinflammatory cytokine, suggesting an immune-modulating role for this organism, in this disorder.

1,358 citations

Journal ArticleDOI
TL;DR: Psychosocial factors, although not part of IBS per se, have an important role in modulating the illness experience and its clinical outcome.

1,348 citations