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G. Gaede

Bio: G. Gaede is an academic researcher from University of Cape Town. The author has an hindex of 1, co-authored 1 publications receiving 86 citations.

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Journal ArticleDOI
TL;DR: Neuropeptides of the adipokinetic hormone (AKH) family regulate inter alia mobilisation of various substrates from stores in the fat body of insects during episodes of flight.

225 citations

Journal ArticleDOI
TL;DR: The involvement of brain neuropeptides in circadian clock function, olfactory processing, various aspects of feeding behavior, and learning and memory are highlighted in this review.
Abstract: A large number of neuropeptides has been identified in the brain of insects. At least 35 neuropeptide precursor genes have been characterized in Drosophila melanogaster, some of which encode multiple peptides. Additional neuropeptides have been found in other insect species. With a few notable exceptions, most of the neuropeptides have been demonstrated in brain interneurons of various types. The products of each neuropeptide precursor seem to be co-expressed, and each precursor displays a unique neuronal distribution pattern. Commonly, each type of neuropeptide is localized to a relatively small number of neurons. We describe the distribution of neuropeptides in brain interneurons of a few well-studied insect species. Emphasis has been placed upon interneurons innervating specific brain areas, such as the optic lobes, accessory medulla, antennal lobes, central body, and mushroom bodies. The functional roles of some neuropeptides and their receptors have been investigated in D. melanogaster by molecular genetics techniques. In addition, behavioral and electrophysiological assays have addressed neuropeptide functions in the cockroach Leucophaea maderae. Thus, the involvement of brain neuropeptides in circadian clock function, olfactory processing, various aspects of feeding behavior, and learning and memory are highlighted in this review. Studies so far indicate that neuropeptides can play a multitude of functional roles in the brain and that even single neuropeptides are likely to be multifunctional.

181 citations

Journal ArticleDOI
TL;DR: Insect sulfakinins, peptides which display substantial sequence similarities with the vertebrate gastrin/CCK peptide family, significantly inhibit food uptake in fifth instar nymphs of the locust, Schistocerca gregaria.

126 citations

Journal ArticleDOI
01 Feb 2001-Peptides
TL;DR: The recently discovered in vivo effects of some of the myotropic peptides, identified in locusts in the past decade, are described.

91 citations

Journal ArticleDOI
TL;DR: The combined data on the primary sequence, gene expression, biosynthesis, release, interaction with the receptor and mode of action provide an accurate account of the current knowledge on how these peptides function.
Abstract: This review deals with those neuropeptidic hormones that are completely known in their primary structure together with the control processes that are linked directly or indirectly to development and reproduction. Actions are assessed for neuropeptides that regulate ecdysteroid and Juvenile Hormone production; oocyte growth or yolk deposition; and ecdysis and courtship behaviour. The combined data on the primary sequence, gene expression, biosynthesis, release, interaction with the receptor and mode of action provide an accurate account of the current knowledge on how these peptides function.

74 citations