Author
G. Gencheva
Bio: G. Gencheva is an academic researcher from Sofia University. The author has contributed to research in topics: Ligand & Hematoporphyrin. The author has an hindex of 8, co-authored 32 publications receiving 190 citations.
Papers
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TL;DR: In this article, a monomeric and dimeric copper(II) complexes with creatinine were synthesized in organic media using spectroscopic (EPR and IR) and magnetochemical methods.
9 citations
TL;DR: Acis-Pt(creat)2(NO2)2 complex was synthesized stereoselectively in a high yield (65%) and characterized by IR spectral and X-ray diffraction analysis as discussed by the authors.
Abstract: Acis-Pt(creat)2(NO2)2 complex was synthesized stereoselectively in a high yield (65%) and characterized by IR spectral and X-ray diffraction analysis. Crystal data: Pt(C4H7N3O)2(NO2)2,Mr=767.55, monoclinic, space groupP21/n,a=9.736(1),b=13.433(1),c=12.098(1) A,β=110.55(1)°,Vc=1482(1) A3,Z=2,Dx=3.441 g cm−3,λ(MoKα)=0.71073 A,μ=97.0 cm−1,F(000)=1504,T=292 K,R=0.026 andRw=0.028 for 2061 observed reflections with I>2σ(I). The structure consists of Pt(creat)2(NO2)2 molecules disposed in general positions and joined by N-H⋯O and N-H⋯N hydrogen bonds. The platinum atom has square-planar PtN4 coordination of twocis disposed pairs of nitro [Pt-Nav 2.023(7) A] and creatinine [Pt-N(endo)av 1.991(8) A] ligands. The creatinine moieties are planar and tilted to the equatorial plane by ~80°.
8 citations
TL;DR: In this paper, the conditions for Pt(III) formation as transient species and its further stabilization as “Platinum Blue” complexes are suggested. And a general method for obtaining “platinum blue” species is suggested.
Abstract: Studying the kinetics of PtCl4
2-
cis-[Pt(NH3)2(H2O)2]2+ and cis-Pt(NH3)2Cl2 (cis-DDP) reactions with different types of ligands using spectrophotometric, Potentiometric and EPR methods, the conditions for Pt(III) formation as transient species and its further stabilization as “Platinum Blue” complexes were found. A general method for obtaining “Platinum Blue” species is suggested.
8 citations
TL;DR: Two coordination compounds of Pd(III) with hematoporphyrin IX showed in vitro cell growth inhibitory effects at micromolar concentration against a panel of human tumor cell lines and a DNA fragmentation assay indicated that the growth inhibition effects are at least partly mediated by induction of apoptosis.
8 citations
TL;DR: In this paper, the structure and coordination mode of the ligand were studied by means of EPR, IR, TG and DTA methods and the results showed that by varying the reaction conditions (acidity, metal-to-ligand ratio, presence of oxygen), different platinum and palladium complexes are obtained.
7 citations
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TL;DR: The spectrum of gold complexes described as antiproliferative compounds comprises a broad variety of different species including many phosphine complexes as well as gold in different oxidation states.
700 citations
TL;DR: In this paper, the main recent advances in the design and synthesis of platinum-and palladium-based drugs, their structural features and biological studies of them are reviewed, and an overview of the main biological techniques and approaches for testing the interaction of these molecules with the biological environment, mainly DNA, to validate the effect is also provided.
187 citations
01 Jun 2013
TL;DR: Recent developments from the laboratory involving monofunctional platinum(II) complexes are described together with a historical account of the manner by which they came to investigate these compounds and their relationship to previously studied molecules.
Abstract: Platinum compounds represent one of the great success stories of metals in medicine. Following the serendipitous discovery of the anticancer activity of cisplatin by Rosenberg, a large number of cisplatin variants have been prepared and tested for their ability to kill cancer cells and inhibit tumor growth. These efforts continue today with increased realization that new strategies are needed to overcome issues of toxicity and resistance inherent to treatment by the approved platinum anticancer agents. One approach has been the use of so-called “non-traditional” platinum(II) and platinum(IV) compounds that violate the structure–activity relationships that governed platinum drug-development research for many years. Another is the use of specialized drug-delivery strategies. Here we describe recent developments from our laboratory involving monofunctional platinum(II) complexes together with a historical account of the manner by which we came to investigate these compounds and their relationship to previous...
169 citations
TL;DR: The photocatalytic H2 evolution of Pt-Ti3+/TiO2 is significantly higher than that of the photoreduced Pt loaded on the original TiO2 and commercial P25, due to the various valence states of Pt (Ptn+, n = 0, 2, or 3), forming Pt-O bonds embedded in the framework of Ti O2 and ultrafine Pt metal nanoparticles on the surface of TiO 2.
Abstract: Pt-doped mesoporous Ti3+ self-doped TiO2 (Pt–Ti3+/TiO2) is in situ synthesized via an ionothermal route, by treating metallic Ti in an ionic liquid containing LiOAc, HOAc, and a H2PtCl6 aqueous solution under mild ionothermal conditions. Such Ti3+-enriched environment, as well as oxygen vacancies, is proven to be effective for allowing the in situ reduction of Pt4+ ions uniformly located in the framework of the TiO2 bulk. The photocatalytic H2 evolution of Pt–Ti3+/TiO2 is significantly higher than that of the photoreduced Pt loaded on the original TiO2 and commercial P25. Such greatly enhanced activity is due to the various valence states of Pt (Ptn+, n = 0, 2, or 3), forming Pt–O bonds embedded in the framework of TiO2 and ultrafine Pt metal nanoparticles on the surface of TiO2. Such Ptn+–O bonds could act as the bridges for facilitating the photogenerated electron transfer from the bulk to the surface of TiO2 with a higher electron carrier density (3.11 × 1020 cm–3), about 2.5 times that (1.25 × 1020 cm...
144 citations