Author
G. Gencheva
Bio: G. Gencheva is an academic researcher from Sofia University. The author has contributed to research in topics: Ligand & Hematoporphyrin. The author has an hindex of 8, co-authored 32 publications receiving 190 citations.
Papers
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TL;DR: In this article, a stable monomeric Pt(III) complex is obtained resulting from PtCl 4 2 - bilirubin interaction in basic-aqueous medium, by means of EPR method it is proven that in the course of the interaction a redox process proceeds, giving rise to a stable Pt( III) complex species and a free radical.
Abstract: A stable monomeric Pt(III) complex is obtained resulting from PtCl 4 2- - bilirubin interaction in basic-aqueous medium. By means of EPR method it is proven that in the course of the interaction a redox process proceeds, giving rise to a stable Pt(III) complex species and a free radical. On the basis of all spectroscopic (EPR, 195 Pt-NMR, IR, UV-Vis) and magnetochemical data obtained a square-pyramidal (e.g. distorted octahedral) structure is suggested. Most likely a biliverdin molecule (oxidation product of bilirubin) is placed in the xy plane, coordinated via the four pyrrole nitrogens of the ligand and the 5th site being occupied by a water molecule.
5 citations
TL;DR: In this paper, the complexation of copper(II) with a new semisynthetic cynnamyl derivative of the antibiotic rifampicin was investigated in methanol solutions using UV-VIS and EPR spectroscopy.
5 citations
5 citations
TL;DR: Pd(creat)2Cl2·2H2O crystallizes in space group P&1macr; with a= 7.257(2), b= 8.159 (2), c= 14.640(2) A, f = 73.0(1), u = 72.22 (2)°, Z=2, and represents a new allotropic form of this compound as discussed by the authors.
Abstract: Pd(creat)2Cl2·2H2O crystallizes in space group P&1macr; with a= 7.257(2), b= 8.159(2), c= 14.640(2) A, f =73.97(2), g =77.0(1), u =72.22(2)°, Z=2, and represents a new allotropic form of this compound. Pd atoms have planar fourfold coordination of N and Cl atoms in trans configuration. Creatinine moieties are coordinated to the Pd atoms via endocyclic N atoms and their essential planarity causes significant delocalization of electron density. The structure is stabilized by a system of weak hydrogen bonds involving interstitial water molecules and creatinine amino-groups.
4 citations
TL;DR: In this article, the formation of an octahedral low-spin PdL was proved exhibiting an anisotropic 2-component EPR spectrum (g1=2.007 and gu=1.998) and effective magnetic moment μeff = 1.7 BM.
Abstract: Formation of transient Pd(III) species was established in the course of PdCL42−-bilirubin (BR) reaction in basic-water medium. Using the EPR method the formation of an octahedral low-spin PdL.2H2O complex was proved exhibiting an anisotropic 2-component EPR spectrum (g1=2.007 and gu=1.998) and effective magnetic moment μeff = 1.7 BM.
4 citations
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TL;DR: The spectrum of gold complexes described as antiproliferative compounds comprises a broad variety of different species including many phosphine complexes as well as gold in different oxidation states.
700 citations
TL;DR: In this paper, the main recent advances in the design and synthesis of platinum-and palladium-based drugs, their structural features and biological studies of them are reviewed, and an overview of the main biological techniques and approaches for testing the interaction of these molecules with the biological environment, mainly DNA, to validate the effect is also provided.
187 citations
01 Jun 2013
TL;DR: Recent developments from the laboratory involving monofunctional platinum(II) complexes are described together with a historical account of the manner by which they came to investigate these compounds and their relationship to previously studied molecules.
Abstract: Platinum compounds represent one of the great success stories of metals in medicine. Following the serendipitous discovery of the anticancer activity of cisplatin by Rosenberg, a large number of cisplatin variants have been prepared and tested for their ability to kill cancer cells and inhibit tumor growth. These efforts continue today with increased realization that new strategies are needed to overcome issues of toxicity and resistance inherent to treatment by the approved platinum anticancer agents. One approach has been the use of so-called “non-traditional” platinum(II) and platinum(IV) compounds that violate the structure–activity relationships that governed platinum drug-development research for many years. Another is the use of specialized drug-delivery strategies. Here we describe recent developments from our laboratory involving monofunctional platinum(II) complexes together with a historical account of the manner by which we came to investigate these compounds and their relationship to previous...
169 citations
TL;DR: The photocatalytic H2 evolution of Pt-Ti3+/TiO2 is significantly higher than that of the photoreduced Pt loaded on the original TiO2 and commercial P25, due to the various valence states of Pt (Ptn+, n = 0, 2, or 3), forming Pt-O bonds embedded in the framework of Ti O2 and ultrafine Pt metal nanoparticles on the surface of TiO 2.
Abstract: Pt-doped mesoporous Ti3+ self-doped TiO2 (Pt–Ti3+/TiO2) is in situ synthesized via an ionothermal route, by treating metallic Ti in an ionic liquid containing LiOAc, HOAc, and a H2PtCl6 aqueous solution under mild ionothermal conditions. Such Ti3+-enriched environment, as well as oxygen vacancies, is proven to be effective for allowing the in situ reduction of Pt4+ ions uniformly located in the framework of the TiO2 bulk. The photocatalytic H2 evolution of Pt–Ti3+/TiO2 is significantly higher than that of the photoreduced Pt loaded on the original TiO2 and commercial P25. Such greatly enhanced activity is due to the various valence states of Pt (Ptn+, n = 0, 2, or 3), forming Pt–O bonds embedded in the framework of TiO2 and ultrafine Pt metal nanoparticles on the surface of TiO2. Such Ptn+–O bonds could act as the bridges for facilitating the photogenerated electron transfer from the bulk to the surface of TiO2 with a higher electron carrier density (3.11 × 1020 cm–3), about 2.5 times that (1.25 × 1020 cm...
144 citations