G
G. M. Durand
Researcher at Albert Einstein College of Medicine
Publications - 5
Citations - 813
G. M. Durand is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Receptor & Alternative splicing. The author has an hindex of 5, co-authored 5 publications receiving 808 citations.
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Splice variants of the N-methyl-D-aspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C
TL;DR: Electrophysiological characterization of six splice variants of the NR1 receptor expressed in Xenopus oocytes identifies the contributions of the separate polypeptide domains to modulation by polyamines and PKC and provides further support for the concept that subunit composition determines functional properties of NMDA receptors.
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Cloning of an apparent splice variant of the rat N-methyl-D-aspartate receptor NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C.
TL;DR: A role for alternate splicing in generating NMDA channels with different functional properties is supported, suggesting that the two forms of the receptor arise by differential splicing of a transcript from the same gene.
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Developmental regulation of mRNAs encoding rat brain kainate/AMPA receptors: a northern analysis study.
G. M. Durand,R. Suzanne Zukin +1 more
TL;DR: Evidence is provided for a developmental regulation of kainate/AMPA receptor gene expression in the brain during the first 2 weeks of postnatal life and predicts a decrease in glutamate‐operated Ca2± permeability mediated through kainATE/ AMPA receptors as a function of age.
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Mutagenesis rescues spermine and Zn2+ potentiation of recombinant NMDA receptors
TL;DR: The positively charged N1 may increase NMDA currents by causing a conformational change similar to that produced by spermine and Zn2+ in NR1 receptors lacking N1.
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