Multiple-input multiple-output (MIMO) technology is maturing and is being incorporated into emerging wireless broadband standards like long-term evolution (LTE) [1]. For example, the LTE standard allows for up to eight antenna ports at the base station. Basically, the more antennas the transmitter/receiver is equipped with, and the more degrees of freedom that the propagation channel can provide, the better the performance in terms of data rate or link reliability. More precisely, on a quasi static channel where a code word spans across only one time and frequency coherence interval, the reliability of a point-to-point MIMO link scales according to Prob(link outage) ` SNR-ntnr where nt and nr are the numbers of transmit and receive antennas, respectively, and signal-to-noise ratio is denoted by SNR. On a channel that varies rapidly as a function of time and frequency, and where circumstances permit coding across many channel coherence intervals, the achievable rate scales as min(nt, nr) log(1 + SNR). The gains in multiuser systems are even more impressive, because such systems offer the possibility to transmit simultaneously to several users and the flexibility to select what users to schedule for reception at any given point in time [2].

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Scaling Up MIMO: Opportunities and Challenges with Very Large Arrays

This paper surveys recent advances in the area of very large MIMO systems. 
With very large MIMO, we think of systems that use antenna arrays with an order of magnitude more elements than in systems being built today, say a hundred antennas or more. Very large MIMO entails an unprecedented number of antennas simultaneously serving a much smaller number of terminals. The disparity in number emerges as a desirable operating condition and a practical one as well. The number of terminals that can be simultaneously served is limited, not by the number of antennas, but rather by our inability to acquire channel-state information for an unlimited number of terminals. Larger numbers of terminals can always be accommodated by combining very large MIMO technology with conventional time- and frequency-division multiplexing via OFDM. Very large MIMO arrays is a new research field both in communication theory, propagation, and electronics and represents a paradigm shift in the way of thinking both with regards to theory, systems and implementation. The ultimate vision of very large MIMO systems is that the antenna array would consist of small active antenna units, plugged into an (optical) fieldbus.

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Scaling up MIMO: Opportunities and Challenges with Very Large Arrays

Photoacoustic (PA) imaging, also called optoacoustic imaging, is a new biomedical imaging modality based on the use of laser-generated ultrasound that has emerged over the last decade. It is a hybrid modality, combining the high-contrast and spectroscopic-based specificity of optical imaging with the high spatial resolution of ultrasound imaging. In essence, a PA image can be regarded as an ultrasound image in which the contrast depends not on the mechanical and elastic properties of the tissue, but its optical properties, specifically optical absorption. As a consequence, it offers greater specificity than conventional ultrasound imaging with the ability to detect haemoglobin, lipids, water and other light-absorbing chomophores, but with greater penetration depth than purely optical imaging modalities that rely on ballistic photons. As well as visualizing anatomical structures such as the microvasculature, it can also provide functional information in the form of blood oxygenation, blood flow and temperature. All of this can be achieved over a wide range of length scales from micrometres to centimetres with scalable spatial resolution. These attributes lend PA imaging to a wide variety of applications in clinical medicine, preclinical research and basic biology for studying cancer, cardiovascular disease, abnormalities of the microcirculation and other conditions. With the emergence of a variety of truly compelling in vivo images obtained by a number of groups around the world in the last 2–3 years, the technique has come of age and the promise of PA imaging is now beginning to be realized. Recent highlights include the demonstration of whole-body small-animal imaging, the first demonstrations of molecular imaging, the introduction of new microscopy modes and the first steps towards clinical breast imaging being taken as well as a myriad of in vivo preclinical imaging studies. In this article, the underlying physical principles of the technique, its practical implementation, and a range of clinical and preclinical applications are reviewed.

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Biomedical photoacoustic imaging

The emergence of ultrafast frame rates in ultrasonic imaging has been recently made possible by the development of new imaging modalities such as transient elastography. Data acquisition rates reaching more than thousands of images per second enable the real-time visualization of shear mechanical waves propagating in biological tissues, which convey information about local viscoelastic properties of tissues. The first proposed approach for reaching such ultrafast frame rates consists of transmitting plane waves into the medium. However, because the beamforming process is then restricted to the receive mode, the echographic images obtained in the ultrafast mode suffer from a low quality in terms of resolution and contrast and affect the robustness of the transient elastography mode. It is here proposed to improve the beamforming process by using a coherent recombination of compounded plane-wave transmissions to recover high-quality echographic images without degrading the high frame rate capabilities. A theoretical model is derived for the comparison between the proposed method and the conventional B-mode imaging in terms of contrast, signal-to-noise ratio, and resolution. Our model predicts that a significantly smaller number of insonifications, 10 times lower, is sufficient to reach an image quality comparable to conventional B-mode. Theoretical predictions are confirmed by in vitro experiments performed in tissue-mimicking phantoms. Such results raise the appeal of coherent compounds for use with standard imaging modes such as B-mode or color flow. Moreover, in the context of transient elastography, ultrafast frame rates can be preserved while increasing the image quality compared with flat insonifications. Improvements on the transient elastography mode are presented and discussed.

Coherent plane-wave compounding for very high frame rate ultrasonography and transient elastography

In complex media such as white paint and biological tissue, light encounters nanoscale refractive-index inhomogeneities that cause multiple scattering. Such scattering is usually seen as an impediment to focusing and imaging. However, scientists have recently used strongly scattering materials to focus, shape and compress waves by controlling the many degrees of freedom in the incident waves. This was first demonstrated in the acoustic and microwave domains using time reversal, and is now being performed in the optical realm using spatial light modulators to address the many thousands of spatial degrees of freedom of light. This approach is being used to investigate phenomena such as optical super-resolution and the time reversal of light, thus opening many new avenues for imaging and focusing in turbid media

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Controlling waves in space and time for imaging and focusing in complex media

This paper presents an initial clinical evaluation of in vivo elastography for breast lesion imaging using the concept of supersonic shear imaging. This technique is based on the combination of a radiation force induced in tissue by an ultrasonic beam and an ultrafast imaging sequence capable of catching in real time the propagation of the resulting shear waves. The local shear wave velocity is recovered using a time-offlight technique and enables the 2-D mapping of shear elasticity. This imaging modality is implemented on a conventional linear probe driven by a dedicated ultrafast echographic device. Consequently, it can be performed during a standard echographic examination. The clinical investigation was performed on 15 patients, which corresponded to 15 lesions (4 cases BI-RADS 3, 7 cases BI-RADS 4 and 4 cases BI-RADS 5). The ability of the supersonic shear imaging technique to provide a quantitative and local estimation of the shear modulus of abnormalities with a millimetric resolution is illustrated on several malignant (invasive ductal and lobular carcinoma) and benign cases (fibrocystic changes and viscous cysts). In the investigated cases, malignant lesions were found to be significantly different from benign solid lesions with respect to their elasticity values. Cystic lesions have shown no shear wave propagate at all in the lesion (because shear waves do not propage in liquid). These preliminary clinical results directly demonstrate the clinical feasibility of this new elastography technique in providing quantitative assessment of relative stiffness of breast tissues. This technique of evaluating tissue elasticity gives valuable information that is complementary to the B-mode morphologic information. More extensive studies are necessary to validate the assumption that this new mode potentially helps the physician in both false-positive and false-negative rejection.

Quantitative assessment of breast lesion viscoelasticity: initial clinical results using supersonic shear imaging.

We report the first experimental demonstration of time-reversal focusing with electromagnetic waves. An antenna transmits a 1-micros electromagnetic pulse at a central frequency of 2.45 GHz in a high-Q cavity. Another antenna records the strongly reverberated signal. The time-reversed wave is built and transmitted back by the same antenna acting now as a time-reversal mirror. The wave is found to converge to its initial source and is compressed in time. The quality of focusing is determined by the frequency bandwidth and the spectral correlations of the field within the cavity.

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Time Reversal of Electromagnetic Waves

The in vivo assessment of the biomechanical properties of the skeletal muscle is a complex issue because the muscle is an anisotropic, viscoelastic and dynamic medium. In this article, these mechanical properties are characterized for the brachialis muscle in vivo using a noninvasive ultrasound-based technique. This supersonic shear imaging technique combines an ultra-fast ultrasonic system and the remote generation of transient mechanical forces into tissue via the radiation force of focused ultrasonic beams. Such an ultrasonic radiation force is induced deep within the muscle by a conventional ultrasonic probe and the resulting shear waves are then imaged with the same probe (5 MHz) at an ultra-fast framerate (up to 5000 frames/s). Local tissue velocity maps are obtained with a conventional speckle tracking technique and provide a full movie of the shear wave propagation through the entire muscle. Shear wave group velocities are then estimated using a time of flight algorithm. This approach provides a complete set of quantitative and in vivo parameters describing the muscle's mechanical properties as a function of active voluntary contraction as well as passive extension of healthy volunteers. Anisotropic properties are also estimated by tilting the probe head with respects to the main muscular fibers direction. Finally, the dispersion of the shear waves is studied for these different configurations and shear modulus and shear viscosity are quantitatively assessed assuming the viscoelastic Voigt's model. (E-mail: jl.gennisson@espci.fr)

Viscoelastic and anisotropic mechanical properties of in vivo muscle tissue assessed by supersonic shear imaging.

We present functional ultrasound (fUS), a method for imaging transient changes in blood volume in the whole brain at better spatiotemporal resolution than with other functional brain imaging modalities. fUS uses plane-wave illumination at high frame rate and can measure blood volumes in smaller vessels than previous ultrasound methods. fUS identifies regions of brain activation and was used to image whisker-evoked cortical and thalamic responses and the propagation of epileptiform seizures in the rat brain.

Gabriel Montaldo

Papers

Coherent plane-wave compounding for very high frame rate ultrasonography and transient elastography

Quantitative assessment of breast lesion viscoelasticity: initial clinical results using supersonic shear imaging.

Time Reversal of Electromagnetic Waves

Viscoelastic and anisotropic mechanical properties of in vivo muscle tissue assessed by supersonic shear imaging.

Functional ultrasound imaging of the brain.