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Gabriela Lombardi
Researcher at Fundación Instituto Leloir
Publications - 5
Citations - 1066
Gabriela Lombardi is an academic researcher from Fundación Instituto Leloir. The author has contributed to research in topics: Dentate gyrus & Neurogenesis. The author has an hindex of 4, co-authored 4 publications receiving 1002 citations.
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Journal ArticleDOI
Neurons born in the adult dentate gyrus form functional synapses with target cells
Nicolas Toni,Diego Andrés Laplagne,Chunmei Zhao,Gabriela Lombardi,Charles E. Ribak,Fred H. Gage,Alejandro F. Schinder +6 more
TL;DR: Structural and functional evidence indicates that axons of adult-born granule cells establish synapses with hilar interneurons, mossy cells and CA3 pyramidal cells and release glutamate as their main neurotransmitter.
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Reliable activation of immature neurons in the adult hippocampus.
TL;DR: It is found that glutamatergic inputs onto young neurons are significantly weaker than those of mature cells, yet stimulation of cortical excitatory axons elicits a similar spiking probability in neurons at either developmental stage.
Journal ArticleDOI
Newborn granule cells in the ageing dentate gyrus.
TL;DR: Surprisingly, granule cells born in 10‐month‐old mice, at which time the rate of neurogenesis has decreased by ∼40‐fold, reach a density of dendritic spines similar to that of neurons born in young adulthood, suggesting that the ageing hippocampus presents a suitable environment for new surviving neurons to reach a high level of complexity, comparable to those of all other dentate granules cells.
Journal ArticleDOI
Delayed dendritic development in newly generated dentate granule cells by cell-autonomous expression of the amyloid precursor protein
Nicolás Andrés Morgenstern,Damiana Giacomini,Gabriela Lombardi,Eduardo M. Castaño,Alejandro F. Schinder +4 more
TL;DR: Results indicate that hAPP can elicit protracted dendritic development independently of the amyloidogenic processing pathway.