G
Galit Lahav
Researcher at Harvard University
Publications - 75
Citations - 8547
Galit Lahav is an academic researcher from Harvard University. The author has contributed to research in topics: DNA damage & Biology. The author has an hindex of 32, co-authored 65 publications receiving 7162 citations. Previous affiliations of Galit Lahav include Weizmann Institute of Science & Broad Institute.
Papers
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Journal ArticleDOI
Dynamics of the p53-Mdm2 feedback loop in individual cells
Galit Lahav,Nitzan Rosenfeld,Alex Sigal,Naama Geva-Zatorsky,Arnold J. Levine,Michael B. Elowitz,Uri Alon +6 more
TL;DR: It is found that p53 was expressed in a series of discrete pulses after DNA damage, and it is suggested that the p53-Mdm2 feedback loop generates a 'digital' clock that releases well-timed quanta of p53 until damage is repaired or the cell dies.
Journal ArticleDOI
Encoding and decoding cellular information through signaling dynamics.
Jeremy E. Purvis,Galit Lahav +1 more
TL;DR: This Review discusses potential functional roles for transmitting cellular information through the dynamics of signaling molecules and possible applications for the treatment of disease.
Journal ArticleDOI
p53 dynamics control cell fate.
TL;DR: The results show that protein dynamics can be an important part of a signal, directly influencing cellular fate decisions, and also alters cell fate: Cells that experience p53 pulses recover from DNA damage, whereas cells exposed to sustained p53 signaling frequently undergo senescence.
Journal ArticleDOI
Oscillations and variability in the p53 system
Naama Geva-Zatorsky,Nitzan Rosenfeld,Shalev Itzkovitz,Ron Milo,Alex Sigal,Erez Dekel,Talia Yarnitzky,Yuvalal Liron,Paz Polak,Galit Lahav,Uri Alon +10 more
TL;DR: A view of the extensive variability of the behavior of a protein circuit in living human cells, both from cell to cell and in the same cell over time is provided.
Journal ArticleDOI
The multiple mechanisms that regulate p53 activity and cell fate
TL;DR: This Review discusses how the interaction of p53 with DNA and chromatin affects gene expression, and how p53 post-translational modifications, its temporal expression dynamics and its interactions with chromatin regulators and transcription factors influence cell fate.