Author
Gameel A. M. El-Hag Ali
Bio: Gameel A. M. El-Hag Ali is an academic researcher from Al-Azhar University. The author has contributed to research in topics: Pyridine & Malononitrile. The author has an hindex of 8, co-authored 15 publications receiving 244 citations.
Topics: Pyridine, Malononitrile, Pyrazole, Carboxamide, Thiazole
Papers
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TL;DR: Molecular docking studies were conducted to investigate the binding mode, amino acid interactions and free binding energy of these potent derivatives, and compounds 4b, 7a and 9 showed more potent activity against EGFR than Lapatinib.
72 citations
Journal Article•
TL;DR: Several novel naphtho [2,1-b]pyrano[2,3-d]pyrimidines, pyrano [3,2-e][1,2,4]triazolo[1,5-c]p Skyrimidines and their coumarin-3-yl derivatives were synthesized and exhibited pronounced antimicrobial activities.
Abstract: Several novel naphtho[2,1-b]pyrano[2,3-d]pyrimidines, pyrano[3,2-e][1,2,4]triazolo[1,5-c]pyrimidines and their coumarin-3-yl derivatives were synthesized Some of these derivatives exhibited pronounced antimicrobial activities
62 citations
TL;DR: The novel synthesized compounds were characterized by IR, (1)H NMR and mass spectral studies and screened in vitro for their antibacterial and antifungal activities.
53 citations
TL;DR: A series of pyrazole derivatives 4, 5, 6, 12, 13, 14 as well as hydrazone derivatives 7, 10, 11 were synthesized starting from adamantane-1-carbohydrazide as the bioactive core.
33 citations
TL;DR: Thiazolo-thiadiazole adamantane derivative 17 exhibited the strongest inhibitory activity to the EGFR, which proved their role as hopeful apoptotic inducers in this research work.
32 citations
Cited by
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TL;DR: This review aims to review the work reported on various biological activities of thiazolidinone derivatives from year 2000 to the beginning of 2011 and presents data for active compounds, some of which have passed the preclinical testing stage.
328 citations
TL;DR: This review summarizes some of the recent effective chemical synthesis (2014-2018) for indole ring and emphasized on the structure-activity relationship (SAR) to reveal the active pharmacophores of various indole analogues accountable for anticancer, anticonvulsant, antimicrobial, antitubercular, antimalarial, antiviral, antidiabetic and other miscellaneous activities which have been investigated in the last five years.
251 citations
TL;DR: A simple, straightforward, and highly efficient multicomponent one-pot synthesis of a pharmaceutically interesting diverse kind of functionalized 2-amino-3-cyano-4H-pyrans and pyran-annulated heterocycles has been developed based on a low-cost and environmentally benign commercially available urea as a novel organo-catalyst as mentioned in this paper.
Abstract: A simple, straightforward, and highly efficient multicomponent one-pot synthesis of a pharmaceutically interesting diverse kind of functionalized 2-amino-3-cyano-4H-pyrans and pyran-annulated heterocycles has been developed based on a low-cost and environmentally benign commercially available urea as a novel organo-catalyst. The reaction occurs via tandem Knoevenagel–cyclocondensation of aldehydes, malononitrile, and C–H-activated acidic compounds in aqueous ethanol at room temperature. Following this protocol, it was possible to synthesize 2-amino-3-cyano-pyrano[3,2-c]chromen-5(4H)-ones (4aa–4al), 2-amino-3-cyano-pyrano[4,3-b]pyran-5(4H)-ones (4ba–4be), 2-amino-3-cyano-7,8-dihydro-4H-chromen-5(6H)-one (4ca–4cr), 1H-pyrano[2,3-d]pyrimidine-2,4(3H,5H)-diones (4da–4dd), 2-amino-3-cyano-5,10-dioxo-5,10-dihydro-4H-benzo[g]chromenes (4ea–4ec), 2-amino-3-cyano-4H-pyrans (4fa–4fh), and 1,4-dihydropyrano[2,3-c]pyrazoles (4ga–4gb). The salient features of the present protocol are mild reaction conditions, excellen...
241 citations
TL;DR: The last section of the review encompasses the various patents granted on 4-thiazolidinone analogs/derivatives with World Intellectual Proprietary Organization and United State Patent Trademark Office (USPTO), particularly in the duration of the year 2000 to the year 2012.
227 citations