Showing papers by "Ganesan Narsimhan published in 2015"
TL;DR: Phytoglycogen (PG), a dendrimer-like glucan particulate, has a much higher dispersed molecular density than amylopectin (AP), and β-amylase was used to investigate the effect of high molecular density on its susceptibility to enzymatic hydrolysis.
16 citations
TL;DR: An all-atom molecular dynamics simulation has been carried out to describe the interaction of two, four, or six peptides placed on the surface of a 3:1 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) lipid bilayer and a mimic of the mammalian cell membrane for asymmetric placement of peptides.
Abstract: Melittin is a naturally occurring antimicrobial peptide that has the ability to kill bacterial cells through cell membrane penetration, leading to pore formation. In this investigation, an all-atom molecular dynamics (MD) simulation has been carried out to describe the interaction of two, four, or six peptides placed on the surface of a 3:1 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/1,2-di(9Z-octadecenoyl)-sn-glycero-3-phospho-(1′-rac-glycerol) (DOPG) lipid bilayer (a mimic of the bacterial cell membrane) corresponding to protein/lipid (P/L) ratios of 2:96, 4:162, or 6:166, respectively. MD simulation was also carried out for (i) one to eight transmembrane peptides (corresponding P/L ratios of 1:128 to 8:128) in a 3:1 DOPC/DOPG mixed membrane for symmetric as well as asymmetric placement of peptides and (ii) four to eight transmembrane peptides (corresponding to P/L ratios of 4:128 to 8:128) for a pure DOPC lipid bilayer (a mimic of the mammalian cell membrane) for the asymmetric placement of peptide...
14 citations
TL;DR: The developed microscopic approach to the theory of nucleation allows one to avoid the controversial application of classical thermodynamics to the description of nuclei which contain a few molecules.
7 citations