Ganesan Narsimhan

Bio: Ganesan Narsimhan is an academic researcher from Purdue University. The author has contributed to research in topics: Adsorption & Emulsion. The author has an hindex of 34, co-authored 140 publications receiving 3465 citations. Previous affiliations of Ganesan Narsimhan include Monash University, Clayton campus & Monash University.

A model for the prediction of precipitation curves for globular proteins with nonionic polymers as the precipitating agent

Abstract: A statistical thermodynamic model for the prediction of precipitation curves of globular proteins using nonionic polymers has been proposed. The model accounts for protein-polymer, polymer-solvent, electrostatic, and hydrophobic interactions as well as the entropy of mixing and employs simplifying assumptions such as spherical globular protein molecule with uniform surface properties and linear, homogeneous polymer uniform with respect to molecular weight. The proposed model can only be employed to predict precipitation curves of charged proteins at sufficiently high ionic strengths since it does not account for electrostatic protein-protein interactions due to overlap of electrical double layers. The model predictions of precipitation curves of human serum albumin (HSA) at the isoelectric point using polyethylene glycol (PEG) for different initial protein concentrations and molecular weights of PEG agreed well with the experimental data. Higher polymer concentrations were found to be required to...

Coarse grain molecular dynamics simulation for the prediction of tertiary conformation of lysozyme adsorbed on silica surface

Abstract: A coarse-grain (CG) algorithm is developed for molecular dynamics (MD) simulation of proteins in which the polypeptide backbone as well as side chains were mapped into spherical interaction centres. The force field parameters for non-bonded interaction between these centres (beads) were evaluated from the interaction of all atoms corresponding to these beads using pairwise additivity. The validity of CG algorithm was demonstrated by comparing the potential energy, radius of gyration (RG), end-to-end distance and root-mean-square deviation with those obtained by all-atom (AA) simulation for a small protein molecule Trp-cage as well as for lysozyme in solution. The CG simulation for lysozyme in solution requires less than 1/50 CPU-time compared to that for the AA method. Also, the CG method converges to equilibrium potential energy much faster than AA simulation. CG simulation for lysozyme adsorbed on silica surface showed that the molecule is more unfolded with a less compact tertiary structure compared to...

Foam formation and stabilization

Abstract: Destabilization of protein-stabilized food foams by some ingredients has been shown to be due to disruption of protein-protein interactions in the adsorbed protein layer. The structure of adsorbed protein layers at air/water interfaces has been elucidated by neutron reflectance. A new mechanism of thin film drainage at high protein concentration has been demonstrated. Drainage models have been developed to predict.syneresis and collapse of equilibrium foams.

Applications of nanotechnology in food packaging and food safety: Barrier materials, antimicrobials and sensors

Abstract: In this article, several applications of nanomaterials in food packaging and food safety are reviewed, including: polymer/clay nanocomposites as high barrier packaging materials, silver nanoparticles as potent antimicrobial agents, and nanosensors and nanomaterial-based assays for the detection of food-relevant analytes (gasses, small organic molecules and food-borne pathogens). In addition to covering the technical aspects of these topics, the current commercial status and understanding of health implications of these technologies are also discussed. These applications were chosen because they do not involve direct addition of nanoparticles to consumed foods, and thus are more likely to be marketed to the public in the short term.

Population Balances: Theory and Applications to Particulate Systems in Engineering

Abstract: Foreword. Preface. Introduction. The Framework of Population Balances. Birth and Death Functions. The Solution of Population Balance Equations. Similarity Behavior of Population Balance Equations. Inverse Problems in Population Balances. The Statistical Foundation of Population Balances. Index.