Author
Gani Bajraktari
Bio: Gani Bajraktari is an academic researcher from Umeå University. The author has contributed to research in topics: Heart failure & Ejection fraction. The author has an hindex of 20, co-authored 97 publications receiving 3495 citations.
Papers published on a yearly basis
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4,069 citations
University of Bologna1, University of Belgrade2, Ljubljana University Medical Centre3, Aristotle University of Thessaloniki4, University of Latvia5, National and Kapodistrian University of Athens6, University of Debrecen7, University College London8, University of Pavol Jozef Šafárik9, University of Zagreb10, Imperial College London11, University of Palermo12, Mashhad University of Medical Sciences13, Emory University14, Johns Hopkins University15, Charles University in Prague16, University of California, Irvine17, Medical University of Łódź18
TL;DR: The purpose of this position paper is to provide consensus-based recommendations for the optimal use of lipid-lowering nutraceuticals to manage dyslipidemia in patients who are still not on statin therapy, patients who have not achieved lipid goals, and patients with statin intolerance.
Abstract: In recent years, there has been growing interest in the possible use of nutraceuticals to improve and optimize dyslipidemia control and therapy. Based on the data from available studies, nutraceuticals might help patients obtain theraputic lipid goals and reduce cardiovascular residual risk. Some nutraceuticals have essential lipid-lowering properties confirmed in studies; some might also have possible positive effects on nonlipid cardiovascular risk factors and have been shown to improve early markers of vascular health such as endothelial function and pulse wave velocity. However, the clinical evidence supporting the use of a single lipid-lowering nutraceutical or a combination of them is largely variable and, for many of the nutraceuticals, the evidence is very limited and, therefore, often debatable. The purpose of this position paper is to provide consensus-based recommendations for the optimal use of lipid-lowering nutraceuticals to manage dyslipidemia in patients who are still not on statin therapy, patients who are on statin or combination therapy but have not achieved lipid goals, and patients with statin intolerance. This statement is intended for physicians and other healthcare professionals engaged in the diagnosis and management of patients with lipid disorders, especially in the primary care setting.
274 citations
University of Palermo1, University of Bologna2, Polish Academy of Sciences3, University of Vienna4, Institute of Chartered Accountants of Nigeria5, University of Belgrade6, Ljubljana University Medical Centre7, University of Göttingen8, Aristotle University of Thessaloniki9, University of Latvia10, University of British Columbia11, University College London12, University of Kansas13, University of Alabama at Birmingham14, National and Kapodistrian University of Athens15, University of Debrecen16, Paracelsus Private Medical University of Salzburg17, University of Pavol Jozef Šafárik18, University of Zagreb19, University of London20, Icahn School of Medicine at Mount Sinai21, Mashhad University of Medical Sciences22, Charles University in Prague23, University of Western Australia24, University of California, Irvine25
TL;DR: The aim of this expert opinion paper is to provide the first attempt at recommendation on the management of statin intolerance through the use of nutraceuticals with particular attention on those with effective low-density lipoprotein cholesterol reduction.
202 citations
University of Bologna1, University of Belgrade2, Ljubljana University Medical Centre3, Aristotle University of Thessaloniki4, University of Latvia5, National and Kapodistrian University of Athens6, University of Debrecen7, University College London8, University of Pavol Jozef Šafárik9, University of Zagreb10, Imperial College London11, University of Palermo12, Mashhad University of Medical Sciences13, Emory University14, Johns Hopkins University15, Charles University in Prague16, University of California, Irvine17, Medical University of Łódź18
TL;DR: This research presents a novel and scalable approach called “SmartCardiology,” which aims to provide real-time information about the activity of the autonomic nervous system and its role in cardiac arrest.
Abstract: 1.1. Cardiovascular disease and dyslipidemia: prevalence and global economic impact
Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, reaching 31% of deaths in 2012 [1]. In particular, atherosclerosis and ischemic heart disease (IHD) are the main causes of premature death in Europe and are responsible for 42% of deaths in women and 38% in men under 75 years old [2]. The global economic impact of CVD is estimated to have been US $906 billion in 2015 and is expected to rise by 22% by 2030 [3]. Cardiovascular diseases also represent the major cause of disability in developed countries. It has been estimated that their growing burden could lead to a global increase in loss of disability-adjusted life years (DALYs), from a loss of 85 million DALYs in 1990 to a loss of ~150 million DALYs in 2020, becoming a major non-psychological cause of lost productivity [4].
Several risk factors contribute to the etiology and development of CVD; they are divided into those modifiable through lifestyle changes or by taking a pharmacologic treatment (e.g. for hypertension, smoking, diabetes mellitus, hypercholesterolemia) and those that are not modifiable (age, male gender, and family history) [5]. Elevated total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) blood concentrations are the major modifiable risk factors for coronary heart disease (CHD), whereas high concentrations of plasma high-density lipoprotein cholesterol (HDL-C) in certain conditions are considered protective [6]. Moreover, LDL-C remains a fundamental CV risk factor (and a main target of therapy) even when statins are largely used in the general population [7].
An examination of the data of 18 053 participants aged ≥ 20 years who participated in the National Health and Nutrition Examination Surveys (NHANES) from 1999 to 2006 showed that the unadjusted prevalence of hypercholesterolemia ranged from 53.2% to 56.1% in United States adults [8]. Differences related to gender and race or ethnicity were observed; in particular, a lower rate of control was found among women than men and lower rates of having a cholesterol check and being told about hypercholesterolemia were reported by African Americans and Mexican Americans than whites [8].
A recent report from the American Heart Association confirmed that in the US only 75.7% of children and 46.6% of adults present targeted TC levels (TC < 170 mg/dl for children and < 200 mg/dl for adults, in untreated individuals) [9]. The pattern is similar in other Western countries [10, 11].
191 citations
TL;DR: Overall, the evidence shows that a clear relationship exists between disease in the coronary and carotid arteries, since conventional risk factors and the extent of stenosis and/or previous events emanating from one artery have a strong bearing on the prevalence of events in the other artery.
144 citations
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TL;DR: A correction has been published: European Heart Journal, ehaa895, https://doi.org/10.1093/eurheartj/ehaa-895.
Abstract: A correction has been published: European Heart Journal, ehaa895, https://doi.org/10.1093/eurheartj/ehaa895
2,361 citations
Maastricht University1, University of Bologna2, University of Melbourne3, Federation University Australia4, University of Leicester5, University of British Columbia6, Imperial College London7, Public Health Foundation of India8, University of London9, University of Western Australia10, Baker IDI Heart and Diabetes Institute11, National and Kapodistrian University of Athens12, Manchester Academic Health Science Centre13, University of Manchester14, Boston University15, University College London16, North-West University17, University of New South Wales18, The George Institute for Global Health19
TL;DR: Document reviewers: Hind Beheiry (Sudan), Irina Chazova (Russia), Albertino Damasceno (Mozambique), Anna Dominiczak (UK), Stephen Harrap (Australia), Hiroshi Itoh (Japan), Tazeen Jafar (Singapore), Marc Jaffe (USA), Patricio Jaramillo-Lopez (Colombia), Kazuomi Kario (Japan).
Abstract: Document reviewers: Hind Beheiry (Sudan), Irina Chazova (Russia), Albertino Damasceno (Mozambique), Anna Dominiczak (UK), Anastase Dzudie (Cameroon), Stephen Harrap (Australia), Hiroshi Itoh (Japan), Tazeen Jafar (Singapore), Marc Jaffe (USA), Patricio Jaramillo-Lopez (Colombia), Kazuomi Kario (Japan), Giuseppe Mancia (Italy), Ana Mocumbi (Mozambique), Sanjeevi N.Narasingan (India), Elijah Ogola (Kenya), Srinath Reddy (India), Ernesto Schiffrin (Canada), Ann Soenarta (Indonesia), Rhian Touyz (UK), Yudah Turana (Indonesia), Michael Weber (USA), Paul Whelton (USA), Xin Hua Zhang, (Australia), Yuqing Zhang (China).
1,657 citations
1,650 citations
Journal Article•
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TL;DR: 1. Place animal in induction chamber and anesthetize the mouse and ensure sedation, move it to a nose cone for hair removal using cream and reduce anesthesia to maintain proper heart rate.
Abstract: 1. Place animal in induction chamber and anesthetize the mouse and ensure sedation. 2. Once the animal is sedated, move it to a nose cone for hair removal using cream. Only apply cream to the area of the chest that will be utilized for imaging. Once the hair is removed, wipe area with wet gauze to ensure all hair is removed. 3. Move the animal to the imaging platform and tape its paws to the ECG lead plates and insert rectal probe. Body temperature should be maintained at 36-37°C. During imaging, reduce anesthesia to maintain proper heart rate. If the animal shows signs of being awake, use a higher concentration of anesthetic.
1,557 citations
TL;DR: In this large, community-based sample, increased body-mass index was associated with an increased risk of heart failure and strategies to promote optimal body weight may reduce the population burden ofheart failure.
1,388 citations