The invention provides a new preparation method of a 2-substituted benzothiazole compound, relating to the field of organic synthesis chemistry. According to the new preparation method, in existence of catalyst, oxidant and additive, methylbenzene or a derivative thereof reacts with o-aminothiophenol through free radial reaction so as to prepare the 2-substituted benzothiazole compound in one step. The new method is an example but not limited and has the beneficial effects that methylbenzene or a derivative thereof and o-aminothiophenol construct a C-S bond and a C-N bond through the free radical method for the first time so as to generate the 2-substituted benzothiazole by coupling reaction in one step, and the new preparation method has advantages that the method is efficient, concise and environmentally friendly, raw materials are easy to obtain, and the product purity is high and the like, and the method has good application value and research prospects.

New preparation method of 2-substituted benzothiazole compound

The invention relates to a method for the catalytic synthesis of a 2-substituted benzothiazole compound by utilizing a Yb/MCM-41 molecular sieve-based catalyst. The method comprises the steps of (a) subjecting 2-amino thiophenol, an aldehyde compound and a Yb/MCM-41 molecular sieve-based catalyst to agitation backflow in an organic solvent at 70 to 90 DEG C for 4-5 hours to obtain a solid-liquid mixture; (b) filtering the solid-liquid mixture obtained in the step (a) to obtain a solid-state product Yb/MCM-41 molecular sieve-based catalyst, recycling and subjecting the filtrate to column chromatography separation, and obtaining the 2-substituted benzothiazole compound after the separating and purifying process. compared with the prior art, the method is mild in reaction condition, simple in operation, high in yield and good in universality. Meanwhile, the catalyst can be recycled.

Method for catalytic synthesis of 2-substituted benzothiazole compound by utilizing Yb/MCM-41 molecular sieve-based catalyst

The invention relates to a synthesis method of an anti-tumor medicine compound, namely a compound shown as the formula (V) A total synthesis route of the synthesis method is shown as the description According to the method provided by the invention, a specific reaction step is carried out; especially in step 1, a catalyst, a nitrogen-containing ligand, an acidic additive and a solvent are comprehensively selected and synergized, so that a brand-new route for synthesizing the anti-tumor medicine compound is obtained and the total yield is high; the source of raw materials is widened and synthesis routes are enriched; the synthesis method has a good application prospect and a good production potential

Synthesis method of anti-tumor medicine compound

The invention relates to a method for synthesizing a pyrrole derivative represented by a formula (6) shown in the description The synthesis method has a reaction route shown in the description The synthesis method comprises the following steps: S1: subjecting a compound represented by a formula (3) shown in the description to a self-cyclization reaction in the presence of an oxidant in an organic solvent, and carrying out aftertreatment after the reaction ends, so as to obtain a compound represented by a formula (4) shown in the description; and S2: subjecting the compound represented by theformula (4) and a compound represented by a formula (5) shown in the description to a reaction in the presence of a palladium catalyst, an organic ligand and an acidic compound in a solvent in a nitrogen atmosphere, and carrying out aftertreatment after the reaction ends, so as to obtain a compound represented by a formula (6) shown in the description According to the method, through creativelyoptimizing a plurality of technical features of each step, a bran-new synthesis method and synthesis route are provided for preparing this kind of compounds, and thus, the method has a good industrialization prospect and a potential application value

Method for synthesizing pyrrole derivative

The invention relates to a synthetic method of an aldehyde multi-substituted heterocyclic aromatic hydrocarbon compound as shown in formula (III). The method comprises the following steps: in an organic solvent, reacting a compound as shown in formula (I) with a compound as shown in formula (II) under the existence of catalysts, alkaline, organic ligands and activators, and thus obtaining the compound as shown in formula (III), wherein X is a halogen. According to the method, the target product can be obtained at a high yield through comprehensive selection and synergistic effect of the catalysts, alkaline, organic ligands and activators, a bran-new reaction path is provided for the synthesis of the compound, and the synthetic method has good application prospect and industrial potential in the field of organic intermediate synthesis.

Synthetic method of aldehyde multi-substituted heterocyclic aromatic hydrocarbon compound

The invention relates to a synthesis method of benzothiazole derivatives, which comprises the following step: in an organic solvent, reacting hydroxyketone compounds and 2-aminothiophenol in the presence of a catalyst and an optional accelerator to synthesize the benzothiazole derivatives. The method has the advantages of high yield, high purity, simple after-treatment and the like, provides a new route and method for synthesis of the benzothiazole derivatives, and has favorable potential applications and research value.

Synthesis method of benzothiazole derivatives

The invention relates to a preparation method of an isoquinoline derivative. The method comprises the step that a dinitrile compound and aryl triborofluoride are reacted in a solvent and in the presence of a palladium catalyst, a containing N-donor ligand and an accelerant to obtain an isoquinoline compound. The method is simple in reaction, simple and convenient to operate and high in yield, and is a brand-new synthesis method of the isoquinoline compound; a new synthesis line is provided for the preparation of such compound; the scientific research value and industrial potential are high.

Preparation method of isoquinoline derivative

The invention relates to a synthesis method of aryl ketone compounds, which comprises the following step: in a reaction solvent, reacting nitrile compounds with aryl boric acid in the presence of a palladium catalyst, a ligand and an accelerator to obtain the aryl ketone compounds. The method has the advantages of simple reaction and high yield, is simple to operate, is a brand-new synthesis method of aryl ketone compounds, provides a new synthesis route for synthesis of the aryl ketone compounds, and has favorable scientific research value and industrialization potential.

Gao Wenxia

Papers

Synthesis method of benzothiazole derivatives

Preparation method of isoquinoline derivative

Synthesis method of aryl ketone compounds