G
Gareth J.S. Jenkins
Researcher at Swansea University
Publications - 128
Citations - 5594
Gareth J.S. Jenkins is an academic researcher from Swansea University. The author has contributed to research in topics: Genotoxicity & Population. The author has an hindex of 32, co-authored 121 publications receiving 4886 citations. Previous affiliations of Gareth J.S. Jenkins include University of Wales & Singleton Hospital.
Papers
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Journal ArticleDOI
NanoGenotoxicology: The DNA damaging potential of engineered nanomaterials
Neenu Singh,Bella B. Manshian,Gareth J.S. Jenkins,Sioned M. Griffiths,Paul M. Williams,Thierry G.G. Maffeis,Chris J. Wright,Shareen H. Doak +7 more
TL;DR: Many of the engineered nanomaterials assessed were found to cause genotoxic responses, such as chromosomal fragmentation, DNA strand breakages, point mutations, oxidative DNA adducts and alterations in gene expression profiles.
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Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION)
TL;DR: Current studies are reviewed and discussed how SPION, with or without different surface coating, may cause cellular perturbations including modulation of actin cytoskeleton, alteration in gene expression profiles, disturbance in iron homeostasis and altered cellular responses such as activation of signalling pathways and impairment of cell cycle regulation.
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Confounding experimental considerations in nanogenotoxicology
Shareen H. Doak,Sioned M. Griffiths,Bella B. Manshian,Neenu Singh,Paul M. Williams,Andy Brown,Gareth J.S. Jenkins +6 more
TL;DR: This report focuses on nanomaterial interactions with colorimetric and fluorometric dyes, components of cell culture growth medium and genotoxicity assay components, and the resultant consequences on test systems are demonstrated.
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In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines
TL;DR: A strategic in vitro genotoxicity testing strategy for nanomaterials is recommended and an in vitro HPRT and micronucleus assays requirenanomaterial specific protocols are recommended.
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Mechanistic Influences for Mutation Induction Curves after Exposure to DNA-Reactive Carcinogens
Shareen H. Doak,Gareth J.S. Jenkins,George E. Johnson,Emma Quick,Elizabeth M. Parry,James M. Parry +5 more
TL;DR: A pragmatic threshold for carcinogenicity may exist for genotoxins treated with alkylating agents that have different mechanisms of action and DNA targets, and nonlinear curves containing a range of nonmutagenic low doses are found.