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Gareth R. A. Adair

Bio: Gareth R. A. Adair is an academic researcher from University of Bath. The author has contributed to research in topics: Ruthenium & Alcohol oxidation. The author has an hindex of 6, co-authored 10 publications receiving 401 citations.

Papers
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TL;DR: In this paper, the authors used Grubbs' catalyst or a ruthenium p-cymene complex without the presence of an added oxidant to achieve the oxidation of alcohols.

133 citations

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TL;DR: Racemic alcohols have been converted into enantiomerically enriched alcohols with up to 99% ee in a one-pot oxidation/reduction procedure.

35 citations

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TL;DR: In this paper, the reduction of alkenes has been achieved using NaBH4 as the reducing agent using 0.5 − 1.0 ǫ−1.0 mM Ru(PPh3)4H2 in the presence of water.

28 citations

Journal ArticleDOI
TL;DR: The deracemisation of alcohols has been achieved with 65-75% ee using a non-selective ruthenium catalysed oxidation to give an intermediate ketone followed by an enantioselective hydrogenation.

23 citations


Cited by
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Journal ArticleDOI
TL;DR: This Review emphasizes the achievements in the selective catalytic functionalization of indoles (C-C bond-forming processes) over the last four years.
Abstract: 140 years ago Adolf von Baeyer proposed the structure of a heteroaromatic compound which revolutionized organic and medical chemistry: indole. After more than a century, indole itself and the complexity of naturally occurring indole derivatives continue to inspire and influence developments in synthetic chemistry. In particular, the ubiquitous presence of indole rings in pharmaceuticals, agrochemicals, and functional materials are testament to the ever increasing interest in the design of mild and efficient synthetic routes to functionalized indole derivatives. This Review emphasizes the achievements in the selective catalytic functionalization of indoles (C-C bond-forming processes) over the last four years.

1,141 citations

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TL;DR: This review describes developments in the burgeoning field of asymmetric ion-pairing catalysis with an emphasis on the insights that have been gleaned into the structural and mechanistic features that contribute to high asymmetric induction.
Abstract: Charged intermediates and reagents are ubiquitous in organic transformations. The interaction of these ionic species with chiral neutral, anionic, or cationic small molecules has emerged as a powerful strategy for catalytic, enantioselective synthesis. This review describes developments in the burgeoning field of asymmetric ion-pairing catalysis with an emphasis on the insights that have been gleaned into the structural and mechanistic features that contribute to high asymmetric induction.

751 citations

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TL;DR: This critical review of the concept of combining transition metal catalysis and organocatalysis with several recent outstanding examples is illustrated, with the aim of shedding light on the synthetic utilities and potentials of this concept as a novel tool in organic synthesis.
Abstract: In recent years, the concept of combining transition metal catalysis and organocatalysis has emerged as a promising strategy for developing new and valuable reactions, and has attracted considerable attention as it could potentially enable unprecedented transformations not currently possible by use of the transition metal complex or the organocatalyst alone. In this critical review, this strategy is illustrated with several recent outstanding examples, with the aim of shedding light on the synthetic utilities and potentials of this concept as a novel tool in organic synthesis (118 references).

652 citations