G
Gary G. Borisy
Researcher at The Forsyth Institute
Publications - 252
Citations - 40358
Gary G. Borisy is an academic researcher from The Forsyth Institute. The author has contributed to research in topics: Microtubule & Tubulin. The author has an hindex of 101, co-authored 248 publications receiving 38195 citations. Previous affiliations of Gary G. Borisy include Johns Hopkins University School of Medicine & Brown University.
Papers
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Journal ArticleDOI
Cell migration: integrating signals from front to back.
Anne J. Ridley,Martin A. Schwartz,Keith Burridge,Richard A. Firtel,Mark H. Ginsberg,Gary G. Borisy,J. Thomas Parsons,Alan Rick Horwitz +7 more
TL;DR: The mechanisms underlying the major steps of migration and the signaling pathways that regulate them are described, and recent advances investigating the nature of polarity in migrating cells and the pathways that establish it are outlined.
Journal ArticleDOI
Cellular Motility Driven by Assembly and Disassembly of Actin Filaments
Thomas D. Pollard,Gary G. Borisy +1 more
TL;DR: A core set of proteins including actin, Arp2/3 complex, profilin, capping protein, and ADF/cofilin can reconstitute the process in vitro, and mathematical models of the constituent reactions predict the rate of motion.
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Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia.
T.M. Svitkina,Gary G. Borisy +1 more
TL;DR: The leading edge of lamellipodia in Xenopus laevis keratocytes and fibroblasts was shown to have an extensively branched organization of actin filaments, which is supported by a dendritic brush, suggesting that ADF/cofilin, per se, is not sufficient for actin brush depolymerization and a regulatory step is required.
Journal ArticleDOI
THE MECHANISM OF ACTION OF COLCHICINE : Binding of Colchincine-3H to Cellular Protein
Gary G. Borisy,Edwin W. Taylor +1 more
TL;DR: The majority of the colchicine-3H bound by tissue culture cells (KB or Hela) was found to be present as a noncovalent complex with a macromolecule which appears in the soluble fraction after homogenization.
Journal ArticleDOI
Antagonism between Ena/VASP Proteins and Actin Filament Capping Regulates Fibroblast Motility
James E. Bear,Tatyana Svitkina,Matthias Krause,Dorothy A. Schafer,Joseph Loureiro,Geraldine A. Strasser,Ivan V. Maly,Oleg Y. Chaga,John A. Cooper,Gary G. Borisy,Frank B. Gertler +10 more
TL;DR: It is concluded that Ena/VASP regulates cell motility by controlling the geometry of actin filament networks within lamellipodia.