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Gaurav Sharma

Other affiliations: Northeastern University, D. E. Shaw & Co., Hewlett-Packard  ...read more
Bio: Gaurav Sharma is an academic researcher from Shenzhen University. The author has contributed to research in topics: Medicine & Photocatalysis. The author has an hindex of 82, co-authored 1244 publications receiving 31482 citations. Previous affiliations of Gaurav Sharma include Northeastern University & D. E. Shaw & Co..


Papers
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Journal Article
TL;DR: The major cause of death was Septicemic shock in 56% cases and mechanical injuries were present in 10% cases as discussed by the authors, while only 5.84% cases of total cases were alleged cases of accident.
Abstract: Burn injuries occur universally and have plagued mankind since antiquity till the present day. Burns represent an extremely stressful experience for both the burn victims as well as their families. An extensive burn profoundly affects the patient's physique, psyche, financial situation and family. Patients with extensive burns frequently die, and for those with lesser injury, physical recovery is slow and painful. In addition to their dramatic physical effects, burn injuries frequently cause deleterious psychological complications. In all societies including developed or developing countries, burns constitute, a medical and psychological problem, but also have severe economic and social consequences not only to them, but also to their family and society ingeneral.24%cases were not hospitalized. 40%cases died within 24 hours of sustaining burns. 38%cases were unconscious before death. 66%cases had given dying declaration.Mechanical injuries were present in 10%cases.84%cases of total cases were alleged casesof accident. The major cause of death was Septicemic shock in 56%cases.

8 citations

Proceedings ArticleDOI
24 Mar 2016
TL;DR: This paper highlights key attributes that distinguish these image-based communications interfaces from other noncontact modes of communication and make their continued use an attractive option.
Abstract: The ubiquitous availability of image sensors in smartphones and other mobile computing devices makes feasible new applications for both barcodes that encode data as image patterns and watermarks that hide data in images. To support these new applications, a number of new methods have been developed for these long-standing image-based data communication interfaces, methods that are better suited for use with the image sensors. In this paper, we review these developments and the applications they enable, drawing upon examples from our own prior work in this area. We highlight key attributes that distinguish these image-based communications interfaces from other noncontact modes of communication and make their continued use an attractive option.

8 citations

Journal ArticleDOI
TL;DR: In this article, pressure-dependent Raman spectroscopic studies on polycrystalline BaTiO3 have been conducted, which showed that it first undergoes a transition from tetragonal to orthorhombic/rhombohedral phase above 26 GPa and then finally goes to cubic phase above 84 GPa.
Abstract: In the earlier pressure-dependent Raman spectroscopic studies, it has been reported that BaTiO3 undergoes a tetragonal to cubic phase transition above ~ 2 GPa, whereas pressure-dependent X-ray absorption, X-ray diffuse scattering studies and pair distribution function studies have reported the presence of a low-symmetry rhombohedral phase above ~ 23 GPa In this report, we present our pressure-dependent Raman spectroscopic studies on polycrystalline BaTiO3 which shows that it first undergoes a transition from tetragonal to orthorhombic/rhombohedral phase above ~ 26 GPa and then finally goes to the cubic phase above 84 GPa Pressure-dependent synchrotron X-ray diffraction (SXRD) studies have also been carried out that provided rate of change of volume as a function of pressure resulting in bulk modulus of 215 ± 9 GPa

8 citations

Journal ArticleDOI
TL;DR: The identification of a small molecule binding site adjacent to the catalytic site of oxidized BpsDsbA is reported, and a fragment that binds at this site with an estimated affinity of KD ~ 500 µM inhibits BpsdsbA enzymatic activity in vitro.
Abstract: The presence of suitable cavities or pockets on protein structures is a general criterion for a therapeutic target protein to be classified as 'druggable'. Many disease-related proteins that function solely through protein-protein interactions lack such pockets, making development of inhibitors by traditional small-molecule structure-based design methods much more challenging. The 22 kDa bacterial thiol oxidoreductase enzyme, DsbA, from the gram-negative bacterium Burkholderia pseudomallei (BpsDsbA) is an example of one such target. The crystal structure of oxidized BpsDsbA lacks well-defined surface pockets. BpsDsbA is required for the correct folding of numerous virulence factors in B. pseudomallei, and genetic deletion of dsbA significantly attenuates B. pseudomallei virulence in murine infection models. Therefore, BpsDsbA is potentially an attractive drug target. Herein we report the identification of a small molecule binding site adjacent to the catalytic site of oxidized BpsDsbA. 1HN CPMG relaxation dispersion NMR measurements suggest that the binding site is formed transiently through protein dynamics. Using fragment-based screening, we identified a small molecule that binds at this site with an estimated affinity of KD ~ 500 µM. This fragment inhibits BpsDsbA enzymatic activity in vitro. The binding mode of this molecule has been characterized by NMR data-driven docking using HADDOCK. These data provide a starting point towards the design of more potent small molecule inhibitors of BpsDsbA.

8 citations

Proceedings ArticleDOI
TL;DR: The interplay between steganographer and the steganalyzer is considered, a steganalysis aware framework for steganography is developed, and a mixture strategies to find the Nash equilibrium of the interplay are considered.
Abstract: We consider the interplay between steganographer and the steganalyzer, and develop a steganalysis aware framework for steganography. The problem of determining a stego image is posed as a feasibility problem subject to constraint of data communication, imperceptibility, and statistical indistinguishability with respect to steganalyzer's features. A stego image is then determined using set theoretic feasible point estimation methods. The proposed framework is applied effectively on a state of the art steganalysis method based on higher order statistics (HOS) steganalysis. We first show that the steganographer can significantly reduce the classification performance of the steganalyzer by employing a statistical constraint during embedding, although the image is highly distorted. Then we show that steganalyzer can develop a counter-strategy against steganographer's action, gaining back some classification performance. This interchange represents an empirical iteration in this game between the steganographer and steganalyzer. Finally we consider mixture strategies to find the Nash equilibrium of the interplay.

8 citations


Cited by
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08 Dec 2001-BMJ
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

33,785 citations

01 Jun 2012
TL;DR: SPAdes as mentioned in this paper is a new assembler for both single-cell and standard (multicell) assembly, and demonstrate that it improves on the recently released E+V-SC assembler and on popular assemblers Velvet and SoapDeNovo (for multicell data).
Abstract: The lion's share of bacteria in various environments cannot be cloned in the laboratory and thus cannot be sequenced using existing technologies. A major goal of single-cell genomics is to complement gene-centric metagenomic data with whole-genome assemblies of uncultivated organisms. Assembly of single-cell data is challenging because of highly non-uniform read coverage as well as elevated levels of sequencing errors and chimeric reads. We describe SPAdes, a new assembler for both single-cell and standard (multicell) assembly, and demonstrate that it improves on the recently released E+V-SC assembler (specialized for single-cell data) and on popular assemblers Velvet and SoapDeNovo (for multicell data). SPAdes generates single-cell assemblies, providing information about genomes of uncultivatable bacteria that vastly exceeds what may be obtained via traditional metagenomics studies. SPAdes is available online ( http://bioinf.spbau.ru/spades ). It is distributed as open source software.

10,124 citations

Journal ArticleDOI

7,335 citations

Journal ArticleDOI

6,278 citations