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Gaurav Sharma

Other affiliations: Northeastern University, D. E. Shaw & Co., Hewlett-Packard  ...read more
Bio: Gaurav Sharma is an academic researcher from Shenzhen University. The author has contributed to research in topics: Medicine & Photocatalysis. The author has an hindex of 82, co-authored 1244 publications receiving 31482 citations. Previous affiliations of Gaurav Sharma include Northeastern University & D. E. Shaw & Co..


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TL;DR: Fluoroboric acid adsorbed on silica-gel has been found to be a new and highly efficient heterogeneous catalyst for thia-Michael addition to α,β-unsaturated carbonyl compounds under solvent-free conditions as discussed by the authors.
Abstract: Fluoroboric acid adsorbed on silica-gel (HBF 4 –SiO 2 ) has been found to be a new and highly efficient heterogeneous catalyst for thia-Michael addition to α,β-unsaturated carbonyl compounds under solvent-free conditions. In the case of 1,3-diaryl-2-propenones, the reactions are best carried out in MeOH. The rate of thia-Michael addition was dependent on the steric hindrance at the β-carbon of the α,β-unsaturated carbonyl substrate as well as surrounding the thiol moiety and was exploited for selective thia-Michael addition during intermolecular competition between two enones with a common thiol and between two aryl/alkyl thiols for a common enone. The methodology finds application for one-pot syntheses of 2,3-dihydro-1,5-benzothiazepines.

5 citations

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TL;DR: Curcumin, a natural product with multiple therapeutic activities (e.g., anti-inflammatory, antioxidant, anticancer, and immunoregulation activities), could revise AFB1-induced harmful effects by targeting these pathways.
Abstract: One of the most significant classes of mycotoxins, aflatoxins (AFTs), can cause a variety of detrimental outcomes, including cancer, hepatitis, aberrant mutations, and reproductive issues. Among the 21 identified AFTs, aflatoxin B1 (AFB1) is the most harmful to humans and animals. The mechanisms of AFB1-induced toxicity are connected to the generation of excess reactive oxygen species (ROS), upregulation of CYP450 activities, oxidative stress, lipid peroxidation, apoptosis, mitochondrial dysfunction, autophagy, necrosis, and inflammatory response. Several signaling pathways, including p53, PI3K/Akt/mTOR, Nrf2/ARE, NF-κB, NLRP3, MAPKs, and Wnt/β-catenin have been shown to contribute to AFB1-mediated toxic effects in mammalian cells. Curcumin, a natural product with multiple therapeutic activities (e.g., anti-inflammatory, antioxidant, anticancer, and immunoregulation activities), could revise AFB1-induced harmful effects by targeting these pathways. Therefore, the potential therapeutic use of curcumin against AFB1-related side effects and the underlying molecular mechanisms are summarized. This review, in our opinion, advances significant knowledge, sparks larger discussions, and drives additional improvements in the hazardous examination of AFTs and detoxifying the application of curcumin.

5 citations

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23 May 2014-Zootaxa
TL;DR: The genus Paraleptomenes Giordani Soika, 1970 is reviewed for the Indian subcontinent and a key to species and a world checklist of species are provided.
Abstract: The genus Paraleptomenes Giordani Soika, 1970 is reviewed for the Indian subcontinent. A new species Paraleptomenes darugiriensis Kumar, Carpenter & Sharma, sp. nov. is described. The male of P. rufoniger Giordani Soika, 1994 is described for the first time. The distribution records of P. humbertianus (de Saussure, 1867), P. miniatus mephitis (Cameron, 1901), P. miniatus miniatus (de Saussure, 1855), and P. rufoniger Giordani Soika, 1994 in the Indian states are augmented. A key to species of the Indian subcontinent and a world checklist of species are provided.

5 citations

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TL;DR: It is concluded that an acute behavioral disturbance in the acute spinal cord injury (SCI) patient can indicate PE, and the recognition of this possibility should lead to prompt investigation for pulmonary embolism.
Abstract: Pulmonary embolism (PE) presented with short lived behavioral disturbances (BD) in four out of 13 consecutive patients with a proven PE. Three patients died of PE with evidence of recurrent thromboembolic disease at autopsy and one survived with PE (demonstrable by lung scanning). It is concluded that an acute behavioral disturbance in the acute spinal cord injury (SCI) patient can indicate PE, and the recognition of this possibility should lead to prompt investigation for pulmonary embolism.

5 citations

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TL;DR: In this paper, the authors found that adipose tissue adjacent to hemodialysis arteriovenous fistulae modulates maturation by reducing the fractional vein diameter during the early time frame of 1 day to 2 weeks (diameter change of 26.6% and 20.4% at the 25th and 75th percentile for IL-6, P = 0.01; 27.8% and 21.1% at 25th, 75th, percentile for MCP-1, P= 0.02), but not in later stages of remod

5 citations


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08 Dec 2001-BMJ
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

33,785 citations

01 Jun 2012
TL;DR: SPAdes as mentioned in this paper is a new assembler for both single-cell and standard (multicell) assembly, and demonstrate that it improves on the recently released E+V-SC assembler and on popular assemblers Velvet and SoapDeNovo (for multicell data).
Abstract: The lion's share of bacteria in various environments cannot be cloned in the laboratory and thus cannot be sequenced using existing technologies. A major goal of single-cell genomics is to complement gene-centric metagenomic data with whole-genome assemblies of uncultivated organisms. Assembly of single-cell data is challenging because of highly non-uniform read coverage as well as elevated levels of sequencing errors and chimeric reads. We describe SPAdes, a new assembler for both single-cell and standard (multicell) assembly, and demonstrate that it improves on the recently released E+V-SC assembler (specialized for single-cell data) and on popular assemblers Velvet and SoapDeNovo (for multicell data). SPAdes generates single-cell assemblies, providing information about genomes of uncultivatable bacteria that vastly exceeds what may be obtained via traditional metagenomics studies. SPAdes is available online ( http://bioinf.spbau.ru/spades ). It is distributed as open source software.

10,124 citations

Journal ArticleDOI

7,335 citations

Journal ArticleDOI

6,278 citations