There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.

Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

I and i

https://caltcm.memberclicks.net/assets/documents/acc_aha_chf_2013_guidelines.pdf

2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines

The lion's share of bacteria in various environments cannot be cloned in the laboratory and thus cannot be sequenced using existing technologies. A major goal of single-cell genomics is to complement gene-centric metagenomic data with whole-genome assemblies of uncultivated organisms. Assembly of single-cell data is challenging because of highly non-uniform read coverage as well as elevated levels of sequencing errors and chimeric reads. We describe SPAdes, a new assembler for both single-cell and standard (multicell) assembly, and demonstrate that it improves on the recently released E+V-SC assembler (specialized for single-cell data) and on popular assemblers Velvet and SoapDeNovo (for multicell data). SPAdes generates single-cell assemblies, providing information about genomes of uncultivatable bacteria that vastly exceeds what may be obtained via traditional metagenomics studies. SPAdes is available online ( http://bioinf.spbau.ru/spades ). It is distributed as open source software.

SPAdes, a new genome assembly algorithm and its applications to single-cell sequencing ( 7th Annual SFAF Meeting, 2012)

Soil Chemical Analysis

Statistics for Spatial Data.

An 82-year-old man presented with episodic pain and a bulge along the right costal margin. He had undergone a minithoracotomy 4 years earlier for biopsy of recurrent squamous-cell carcinoma in the right lung.

Images in clinical medicine. Transdiaphragmatic intercostal herniation of the gallbladder.

We explore sensor scheduling strategies to maximize the operational lifetime of a user-centric image sensor
network. Image sensors are deployed for gathering visual information over a monitored region. Users navigate
within this region by specifying a time-varing desired viewpoint and the network responds with the requested
visual data. By modeling the user's desired viewpoint in a probabilistic framework, we develop a stochastic
formulation of the network lifetime and investigate the camera scheduling strategy that maximizes the expected
value of network lifetime. By suitably abstracting the problem, we present a closed-form solution for the simplistic
case when the monitored region is divided into two parts. Using asymptotic analysis, we then present a simple
camera scheduling strategy for the general case that we conjecture to be optimal. Simulation results demonstrate
a clear advantage of the proposed camera scheduling approach over previously considered alternatives.

Sensor scheduling for lifetime maximization in user-centric sensor networks

Error-diffusion and its variants are commonly used halftoning techniques that produce dispersed dot (FM) halftones, which are often preferred because they are free from low-frequency structure. Since the isolated dots resulting from error diffusion are reproduced well on inkjet printers, error diffusion is commonly employed in these devices. Inkjet printers often print a page in two passes in order to allow for better drying of inks and to minimize appearance of a head signature. Any potential misregistration between the passes is typically not comprehended in the error-diffusion halftoning process. The mis-registration between the passes can therefore cause significantly increased graininess (low-frequency structure) in printed error diffusion images even though the electronic bitmaps generated by error diffusion are free from low-frequency structure. In this paper, we propose modifications to the error-diffusion halftoning process that take the two pass printing into account and produce halftones that are robust to inter-pass mis-registration errors. This allows reduced tolerances and alignment requirements in manufacturing that translate to lower cost. The proposed technique works by suitably biasing the error diffusion process to ensure that a majority of the minority pixels are concentrated in a single pass, which provides improved robustness to mis-registration between the passes. Experimental results demonstrate that the modified error-diffusion technique performs significantly better than regular error diffusion in the presence of mis-registration errors.

Error-Diffusion Robust to Mis-Registration in Multi-Pass Printing.

The recent outbreak of COVID-19 infection started in Wuhan, China, and spread across China and beyond. Since the WHO declared COVID-19 a pandemic (March 11, 2020), three vaccines and only one antiviral drug (remdesivir) have been approved (Oct 22, 2020) by the FDA. The coronavirus enters human epithelial cells by the binding of the densely glycosylated fusion spike protein (S protein) to a receptor (angiotensin-converting enzyme 2, ACE2) on the host cell surface. Therefore, inhibiting the viral entry is a promising treatment pathway for preventing or ameliorating the effects of COVID-19 infection. In the current work, we have used all-atom molecular dynamics (MD) simulations to investigate the influence of the MLN-4760 inhibitor on the conformational properties of ACE2 and its interaction with the receptor-binding domain (RBD) of SARS-CoV-2. We have found that the presence of an inhibitor tends to completely/partially open the ACE2 receptor where the two subdomains (I and II) move away from each other, while the absence results in partial or complete closure. The current study increases our understanding of ACE inhibition by MLN-4760 and how it modulates the conformational properties of ACE2.

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.1c01283

Effect of an Inhibitor on the ACE2-Receptor-Binding Domain of SARS-CoV-2

Cross-polarized optical coherence tomography offers improved contrast for samples which can alter the polarization of light when it interacts with the sample. This property has been utilized to screen pathological conditions in several organs. Existing cross-polarized optical coherence tomography systems require several polarization-controlling elements to minimize the optical fiber movement-related image artifacts. In this work, we demonstrate a cross-polarized optical coherence tomography system using unpolarized light and only two quarter-wave plates, which is free from fiber-induced image artifacts. The simplicity of the approach will find many applications in clinical settings.

/pdf/cross-polarized-optical-coherence-tomography-system-with-15l2zs6c.pdf

Gaurav Sharma

Papers

Images in clinical medicine. Transdiaphragmatic intercostal herniation of the gallbladder.

Sensor scheduling for lifetime maximization in user-centric sensor networks

Error-Diffusion Robust to Mis-Registration in Multi-Pass Printing.

Effect of an Inhibitor on the ACE2-Receptor-Binding Domain of SARS-CoV-2

Cross-Polarized Optical Coherence Tomography System with Unpolarized Light