There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.

Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

I and i

https://caltcm.memberclicks.net/assets/documents/acc_aha_chf_2013_guidelines.pdf

2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines

The lion's share of bacteria in various environments cannot be cloned in the laboratory and thus cannot be sequenced using existing technologies. A major goal of single-cell genomics is to complement gene-centric metagenomic data with whole-genome assemblies of uncultivated organisms. Assembly of single-cell data is challenging because of highly non-uniform read coverage as well as elevated levels of sequencing errors and chimeric reads. We describe SPAdes, a new assembler for both single-cell and standard (multicell) assembly, and demonstrate that it improves on the recently released E+V-SC assembler (specialized for single-cell data) and on popular assemblers Velvet and SoapDeNovo (for multicell data). SPAdes generates single-cell assemblies, providing information about genomes of uncultivatable bacteria that vastly exceeds what may be obtained via traditional metagenomics studies. SPAdes is available online ( http://bioinf.spbau.ru/spades ). It is distributed as open source software.

SPAdes, a new genome assembly algorithm and its applications to single-cell sequencing ( 7th Annual SFAF Meeting, 2012)

Soil Chemical Analysis

Statistics for Spatial Data.

We introduce an optimum watermark embedding technique that satisfies common watermarking requirements such as visual fidelity, sufficient embedding rate, robustness against noise and tolerance to benign signal processing, while optimizing one of these requirements. The algorithm distinguishes itself from other watermark optimization techniques in its flexibility for incorporating constraints and in assuring convergence to the globally optimum point when all constraints are convex. The proposed scheme is a natural extension of set-theoretic watermark design and inherits all the advantages of it. A watermarked image is first obtained by POCS, then optimum watermarked image is determined by an iterative search procedure based on a simple bi-section method. Experimental results are presented to illustrate the effectiveness of the method.

/pdf/optimum-watermark-design-by-vector-space-projections-5eb57znhhl.pdf

Optimum Watermark Design by Vector Space Projections

Background
There is limited knowledge of the genetic alterations in acral melanoma metastases at different anatomic sites. Here, we characterized the genetic abnormalities of metastases in a 51-year-old man with stage IIIC heel melanoma who developed concomitant brain and cutaneous metastases in spite of multiple treatment modalities.

Methods
Melanoma cells were isolated following palliative resection of the patient's cortical tumor and biopsy of cutaneous thigh metastasis. Mutational analysis using polymerase chain reaction amplification and BLAST, as well as exome sequencing (160 Mb coverage) was performed on the tumors, cell lines generated thereof and normal lymph nodes.

Results
All specimens had neuroblastoma RAS viral oncogene homolog Q61K mutations. There was a 40-fold higher somatic mutation frequency in the brain metastasis compared to the cutaneous metastasis. The former showed truncations of DNA mismatch repair genes (MLH1 and MSH2), and non-canonical BRAF (v-raf murine sarcoma viral oncogene homolog B1), PIK3CA and NF-1 mutations not observed in the extracranial lesion. Genomic profiling of each cell line was concordant with the respective original tumor tissue.

Conclusions
We present the mutational differences between brain and cutaneous acral melanoma metastases in a patient with concomitant lesions. Further genetic and functional studies are needed to understand the biology of metastatic disease appearing at different sites.

/pdf/distinct-genetic-profiles-of-extracranial-and-intracranial-1cya3y1pvw.pdf

Distinct genetic profiles of extracranial and intracranial acral melanoma metastases.

With the continuous improvements and advancements in traditional bismuth oxy halides, the bismuth-rich oxy halides (BixOyXz) exhibit exceptional photo catalytic performance due to their distinct and promising band gap, electrical conductivity and stability. As an emerging new type of photo catalysts, BixOyXz with more tunable optical properties and band structure, the enhanced photocatalytic potential for the degradation of pollutants, clean energy conversion, nitrogen fixation, and so on has been tested in recent times. The better properties of BixOyXz (X = Cl, Br, I) arise from the distinct atomic structure of them. The sole purpose of the current review is state-of-art advances in environmental applications of BixOyXz and various photocatalysts based on them. Strategies of various insight synthesis routes for BixOyXz and their composites/heterojunctions and tailored methods for specific applications and desired properties are also discussed. The work is focused on highlighting the inter linkage between the photo catalytic behavior of BixOyXz and their modified properties via the structural modifications and formations of suitable heterostructures. To summarize the existing challenges, bottlenecks, advances and future perspectives for new opportunities have been presented. 

Advances in photocatalytic environmental and clean energy applications of Bismuth-rich oxy halides (BixOyXz) based heterojunctions: A review

Study was conducted in LHMC & Associated Smt Sucheta Kriplani Hospital New Delhi to estimate age from central maxillary incisor by calculating the index value of attrition. Total number of cases studied was one hundred and fifty. The objectives of the study were to evaluate the degree of attrition as objectively as possible, neutralizing the role of oral pathology and its correlation with age.

Determination of age from teeth using index value of attrition

Gladiolus (Gladiolus grandiflorus L.) is an important ornamental and commercial flower, belongs to the family Iridaceae. Gladiolus is a flower of glamour and perfection which is known as the queen of bulbous flowers due to its flower spikes with florets of massive form and excellent self life. It is a popular flowering plant and is a native of South Africa and Asia Minor. In India gladiolus has become the most popular commercial cut flower crop and the demand for multicolored varieties are increasing day by day. There are about 260 species in genus Gladiolus (Singh et al., 2006). The presently cultivated gladiolus hybrids (G. grandiflorus L.) have been developed genetically from 20-25 species out of many species found in its native.

Gaurav Sharma

Papers

Optimum Watermark Design by Vector Space Projections

Distinct genetic profiles of extracranial and intracranial acral melanoma metastases.

Advances in photocatalytic environmental and clean energy applications of Bismuth-rich oxy halides (BixOyXz) based heterojunctions: A review

Determination of age from teeth using index value of attrition

INDUCED MUTAGTENESIS FOR MORPHOLOGICAL CHANGES IN GLADIOLUS (Gladiolus grandiflorus L.