G
Gavin MacBeath
Researcher at Harvard University
Publications - 123
Citations - 10772
Gavin MacBeath is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Signal transduction. The author has an hindex of 39, co-authored 118 publications receiving 9912 citations. Previous affiliations of Gavin MacBeath include University of Manitoba & École Polytechnique Fédérale de Lausanne.
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Printing proteins as microarrays for high-throughput function determination.
TL;DR: Miniaturized assays that accommodate extremely low sample volumes and enable the rapid, simultaneous processing of thousands of proteins are developed to facilitate subsequent studies of protein function.
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Protein microarrays and proteomics
TL;DR: The role of microarray technology is discussed in this burgeoning area of proteomics, which aims to learn how proteins interact with each other, as well as with non-proteinaceous molecules, to control complex processes in cells, tissues and even whole organisms.
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A quantitative protein interaction network for the ErbB receptors using protein microarrays
TL;DR: The extent to which promiscuity changes with protein concentration may contribute to the oncogenic potential of receptor tyrosine kinases, and perhaps other signalling proteins as well.
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Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks
Michael J. Lee,Albert S. Ye,Albert S. Ye,Alexandra K. Gardino,Anne Margriet Heijink,Peter K. Sorger,Peter K. Sorger,Gavin MacBeath,Gavin MacBeath,Michael B. Yaffe +9 more
TL;DR: Using targeted inhibition of oncogenic signaling pathways, combined with DNA-damaging chemotherapy, it is reported that time-staggered EGFR inhibition, but not simultaneous coadministration, dramatically sensitizes a subset of triple-negative breast cancer cells to genotoxic drugs.
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Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells
Alex K. Shalek,Jacob T. Robinson,Ethan S. Karp,Jin Seok Lee,Dae-Ro Ahn,Myung-Han Yoon,Amy K. Sutton,Marsela Jorgolli,Rona S. Gertner,Taranjit S. Gujral,Gavin MacBeath,Eun Gyeong Yang,Hongkun Park +12 more
TL;DR: It is shown that this platform can be used to guide neuronal progenitor growth with small molecules, knock down transcript levels by delivering siRNAs, inhibit apoptosis using peptides, and introduce targeted proteins to specific organelles.