G
Gavin Y. Oudit
Researcher at University of Alberta
Publications - 374
Citations - 24481
Gavin Y. Oudit is an academic researcher from University of Alberta. The author has contributed to research in topics: Heart failure & Medicine. The author has an hindex of 74, co-authored 327 publications receiving 19506 citations. Previous affiliations of Gavin Y. Oudit include Toronto General Hospital & Indiana University.
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Journal ArticleDOI
Angiotensin-converting enzyme 2 is an essential regulator of heart function
Michael A. Crackower,Renu Sarao,Renu Sarao,Gavin Y. Oudit,Gavin Y. Oudit,Chana Yagil,Ivona Kozieradzki,Ivona Kozieradzki,Sam E. Scanga,Antonio J. Oliveira-dos-Santos,Joan da Costa,Liyong Zhang,York Pei,James W. Scholey,Carlos M. Ferrario,Armen S. Manoukian,Mark C. Chappell,Peter H. Backx,Peter H. Backx,Yoram Yagil,Josef M. Penninger +20 more
TL;DR: These genetic data for ACE2 show that it is an essential regulator of heart function in vivo and targeted disruption of ACE2 in mice results in a severe cardiac contractility defect, increased angiotensin II levels, and upregulation of hypoxia-induced genes in the heart.
Journal ArticleDOI
Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2.
Mahmoud Gheblawi,Kaiming Wang,Anissa Viveiros,Quynh Nguyen,Jiu Chang Zhong,Anthony J. Turner,Mohan K. Raizada,Maria B. Grant,Gavin Y. Oudit +8 more
TL;DR: A review summarizes the progress over the past 20 years, highlighting the critical role of ACE2 as the novel SARS-CoV-2 receptor and as the negative regulator of the renin-angiotensin system, together with implications for the coronavirus disease 2019 pandemic and associated cardiovascular diseases.
Journal ArticleDOI
SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS.
Gavin Y. Oudit,Zamaneh Kassiri,C. Jiang,Peter P. Liu,Susan M. Poutanen,Josef M. Penninger,Jagdish Butany +6 more
TL;DR: This study has shown that angiotensin converting enzyme 2 (ACE2) is a functional receptor for severe acute respiratory syndrome (SARS) coronavirus and is highly expressed in the lungs and heart and patients with SARS also suffered from cardiac disease.
Journal ArticleDOI
Cells of the adult human heart.
Monika Litviňuková,Monika Litviňuková,Carlos Talavera-López,Carlos Talavera-López,Henrike Maatz,Daniel Reichart,Daniel Reichart,Catherine L. Worth,Eric L. Lindberg,Masatoshi Kanda,Masatoshi Kanda,Krzysztof Polanski,Matthias Heinig,Michael Lee,Emily R. Nadelmann,Kenny Roberts,Liz Tuck,Eirini S. Fasouli,Daniel M. DeLaughter,Barbara McDonough,Barbara McDonough,Barbara McDonough,Hiroko Wakimoto,Joshua M. Gorham,Sara Samari,Krishnaa T. Mahbubani,Kourosh Saeb-Parsy,Giannino Patone,Joseph J. Boyle,Hongbo Zhang,Hongbo Zhang,Hao Zhang,Anissa Viveiros,Gavin Y. Oudit,Omer Ali Bayraktar,Jonathan G. Seidman,Christine E. Seidman,Christine E. Seidman,Christine E. Seidman,Michela Noseda,Michela Noseda,Norbert Hubner,Sarah A. Teichmann,Sarah A. Teichmann +43 more
TL;DR: The state-of-the-art analyses of large-scale single-cell and single-nucleus transcriptomes are used to construct a cellular atlas of the human heart that will aid further research into cardiac physiology and disease and provides a valuable reference for future studies.
Journal ArticleDOI
Role of the ACE2/Angiotensin 1-7 Axis of the Renin-Angiotensin System in Heart Failure.
TL;DR: The transcriptional and post-transcriptional regulation of ACE2 and the role of the ACE2/Ang 1-7 axis in cardiac physiology and in the pathophysiology of HF are discussed and the pharmacological and therapeutic potential of enhancing ACE2 /Ang1-7 action as a novel therapy for HF is highlighted.