Geert R. Verheyen

TL;DR: The response of miR-122 paralleled that of other markers and was consistent with liver injury as indicated by histopathological evaluation and changed earlier than standard liver injury markers and exhibited a wide dynamic range.

TL;DR: The liver RNA samples from drug-treated rats from more recent experiments were examined for statistical fit to the OS/RM signature, and nine drugs linked to idiosyncratic hepatotoxicity of drug candidates were identified.

TL;DR: Modulation indicates that during phospholipidosis-induction interactions take place between the cationic amphiphilic drug andospholipids at the level of BMP-rich internal membranes of endosomes, impeding cholesterol sorting and leading to an accumulation of internal membranes, converting into multilamellar bodies.

TL;DR: By considering the proposed plasma concentration at the efficacious dose, the in vitro low throughput assay is preferred above high throughput in silico assays, characterized by a high false positive rate.

TL;DR: The automated image recording of contractile cardiomyocyte-like cells in the EST allows for an unbiased high throughput method to assess the embryotoxic potency of test compounds, resulting in an outcome comparable to manual analysis.