G
Geertruida M. Veldman
Researcher at Genetics Institute, Inc.
Publications - 62
Citations - 4832
Geertruida M. Veldman is an academic researcher from Genetics Institute, Inc.. The author has contributed to research in topics: Antibody & Peptide sequence. The author has an hindex of 22, co-authored 61 publications receiving 4657 citations. Previous affiliations of Geertruida M. Veldman include MedImmune & Pfizer.
Papers
More filters
Journal ArticleDOI
Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis.
Sha Mi,Xinhua Lee,Xiangping Li,Geertruida M. Veldman,Heather Finnerty,Lisa A. Racie,Edward R. Lavallie,Xiang-Yang Tang,Philippe Edouard,Steve Howes,James C. Keith,John M. Mccoy,John M. Mccoy +12 more
TL;DR: It is shown that expression of recombinant syncytin in a wide variety of cell types induces the formation of giant syncytia, and that fusion of a human trophoblastic cell line expressing endogenousSyncytin can be inhibited by an anti-syncytin antiserum, and thus may be important in human placental morphogenesis.
Journal ArticleDOI
Expression cloning of a functional glycoprotein ligand for P-selectin
Sako Dianne S,Xiao-Jia Chang,Karen M. Barone,Gloria Vachino,Holly M. White,Gray D. Shaw,Geertruida M. Veldman,Kevin M. Bean,Ahern Tim J,Bruce Furie,Dale A. Cumming,Glenn R. Larsen +11 more
TL;DR: The expression cloning of a functional ligand for P-selectin from an HL-60 cDNA library is reported, and the predicted amino acid sequence reveals a novel mucin-like transmembrane protein.
Journal ArticleDOI
Inhibition of myostatin in adult mice increases skeletal muscle mass and strength
Lisa-Anne Whittemore,Kening Song,Xiangping Li,Jane Aghajanian,Monique V. Davies,Stefan Girgenrath,Jennifer J. Hill,Mary Jalenak,Pamela Kelley,Andrea Knight,Rich Maylor,Denise O'Hara,Adele A. Pearson,Amira Quazi,Stephanie Ryerson,Xiang Yang Tan,Kathleen N. Tomkinson,Geertruida M. Veldman,Angela Widom,Jill F. Wright,Steve Wudyka,Liz Zhao,Neil M. Wolfman +22 more
TL;DR: It is shown for the first time that myostatin acts postnatally as a negative regulator of skeletal muscle growth and suggest that hisostatin inhibitors could provide a therapeutic benefit in diseases for which muscle mass is limiting.
Patent
Human antibodies that bind human IL-12 and methods for producing
Jochen G. Salfeld,Michael Roguska,Michael Paskind,Subhashis Banerjee,Daniel E. Tracey,Michael White,Zehra Kaymakcalan,Boris Labkovsky,Paul Sakorafas,Geertruida M. Veldman,Amy Venturini,Angela Widom,Stuart Friedrich,Nicholas W. Warne,Angela Myles,John Gawain Elvin,Duncan Alexander R,Elaine J. Derbyshire,Sara Carmen,Stephen Smith,Thor Las Holtet,Sarah Leila Du Fou +21 more
TL;DR: In this paper, human antibodies, preferably recombinant human antibodies that specifically bind to human interleukin-12 (hIL-12) are disclosed, which can be a full-length antibody or an antigen-binding portion thereof.
Journal ArticleDOI
Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses.
Frann Bennett,Deborah Luxenberg,Vincent Ling,I-Ming Wang,Kim Marquette,David C. Lowe,Nighat Khan,Geertruida M. Veldman,Kenneth Jacobs,Viia Valge-Archer,Mary Collins,Beatriz M. Carreno +11 more
TL;DR: It is suggested that IL-7 and IL-15 restore proliferation under conditions of PD-1 engagement by enhancing high-affinity IL-2R expression and hence,IL-2 responsiveness, and thus, STAT5 has been implicated in the maintenance of IL- 2Rα expression.