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Geir Bjørkøy

Researcher at Norwegian University of Science and Technology

Publications -  58
Citations -  16416

Geir Bjørkøy is an academic researcher from Norwegian University of Science and Technology. The author has contributed to research in topics: Autophagy & Cancer. The author has an hindex of 29, co-authored 49 publications receiving 14124 citations. Previous affiliations of Geir Bjørkøy include University of Tromsø & Sør-Trøndelag University College.

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Journal ArticleDOI

p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

Serhiy Pankiv, +8 more
- 17 Aug 2007 - 
TL;DR: It is demonstrated that the previously reported aggresome-like induced structures containing ubiquitinated proteins in cytosolic bodies are dependent on p62 for their formation and p62 is required both for the formation and the degradation of polyubiquitin-containing bodies by autophagy.

p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates

Serhiy Pankiv, +9 more
TL;DR: In this article, the authors showed that the polyubiquitin-binding protein p62/SQSTM1 is degraded by autophagy by using a 22-residue sequence of p62 containing an evolutionarily conserved motif.
Journal ArticleDOI

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Geir Bjørkøy, +7 more
- 21 Nov 2005 - 
TL;DR: In this article, the polyubiquitin-binding protein p62/SQSTM1 has been shown to be involved in linking polyUBiquitinated protein aggregates to the autophagy machinery.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

Vladimir Kirkin, +17 more
- 27 Feb 2009 - 
TL;DR: NBR1 (neighbor of BRCA1 gene 1) is an autophagy receptor containing LC3- and ubiquitin (Ub)-binding domains and it is proposed that NBR1 and p62 act as receptors for selective autophagosomal degradation of ubiquitinated targets.